A5087226997- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Carbohydrate Chemistry and Synthesis
- Grey System Theory Applications
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- Fuzzy Systems and Optimization
- RNA Interference and Gene Delivery
- Syphilis Diagnosis and Treatment
- interferon and immune responses
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Analysis
- MicroRNA in disease regulation
- Microbial Natural Products and Biosynthesis
- Vaccine Coverage and Hesitancy
- Tuberculosis Research and Epidemiology
- Endoplasmic Reticulum Stress and Disease
- DNA and Nucleic Acid Chemistry
Guangxi Medical University
2016-2025
Hepatitis is a serious public health problem with increasing cases and property damage in Heng County. It necessary to develop model predict the hepatitis epidemic that could be useful for preventing this disease.The autoregressive integrated moving average (ARIMA) generalized regression neural network (GRNN) were used fit incidence data from County CDC (Center Disease Control Prevention) January 2005 December 2012. Then, ARIMA-GRNN hybrid was developed. The 2013 validate models. Several...
The study aims to investigate the demographic characteristics, variations in their immune status, and mortality risk among HIV-1 infection long-term non-progressors (LTNP). Eligible LTNP typical progressors (TP) were recruited Guangxi by December 2018. Participants followed up until 2022, monitoring ART CD4+ T cell counts, survival/death outcomes. Multivariate logistic, Cox regression, Kaplan-Meier method employed scrutinize associated factors of LTNP. A total 212 390 TP included. cohort...
Objective To characterise the association between duration of exposure to antiretroviral treatment (ART) and liver damage in HIV patients with an initially normal baseline function without hepatitis B virus (HBV)/hepatitis C (HCV) infection. Methods A retrospective cohort study was conducted HIV-infected individuals parameters at ART initiation HBV/HCV infection, from 14 April 2004 13 2015 Guigang city, Guangxi, China. The (grade II–IV enzyme elevation [LEE] and/or total bilirubin [TBE]),...
Abstract Both alcohol and hepatitis C virus (HCV) infection could induce cellular autophagy in liver cells, which is considered to be essential for productive HCV replication. However, whether alcohol-induced involved the pathogenesis of still poorly understood. Alcohol treatment Huh7 cells (a hepatoma cell line that supports JFH-1 replication), evidenced by increase LC3B-II levels, conversion LC3B-I LC3B-II, formation GFP-LC3 puncta as well decrease p62 level alcohol-treated compared with...
Abstract Previous studies investigating HIV-infected patients suggested a direct link between underweight and the mortality rate of AIDS. However, there was lack evidence showing optimal range initial body mass index (BMI) maintain during antiretroviral therapy (ART). We aimed to evaluate associations BMI values pre-ART entire ART duration with among HIV-positive individuals. In total, 5101 HIV/AIDS patients, including 1439 (28.2%) underweight, 3047 (59.7%) normal-weight, 548 (10.7%)...
Abstract Background Previous studies have shown the association between tuberculosis (TB) and meteorological factors/air pollutants. However, little information is available for people living with HIV/AIDS (PLWHA), who are highly susceptible to TB. Method Data regarding TB cases in PLWHA from 2014 to2020 were collected HIV antiviral therapy cohort Guangxi, China. Meteorological air pollutants data same period obtained China Science Sharing Service Network Department of Ecology Environment...
It is a daunting task to eradicate tuberculosis completely in Heng County due large transient population, human immunodeficiency virus/tuberculosis coinfection, and latent infection. Thus, high-precision forecasting model can be used for the prevention control of tuberculosis. In this study, four models including basic autoregressive integrated moving average (ARIMA) model, traditional ARIMA-generalized regression neural network (GRNN) GRNN new ARIMA-GRNN hybrid were fit predict incidence...
The dimorphic fungus Talaromyces marneffei (TM) is a common cause of HIV-associated opportunistic infections in Southeast Asia. Cotrimoxazole (CTX) inhibits folic acid synthesis which important for the survival many bacteria, protozoa, and fungi has been used to prevent several among HIV/AIDS patients. We question whether CTX effective preventing TM infection. To investigate this question, we conducted an 11-year (2005-2016) retrospective observational cohort study all patients on Chinese...
Female sex workers (FSW) are a population that at high risk for HIV infection, and their HIV/AIDS knowledge levels sexual behaviors of concern. This study describes changes in prevalence factors associated among female Guigang City, Guangxi, one the highest areas China. Data were derived from an annual cross-sectional venue-based survey, 2008 to 2015, form sentinel surveillance. The participants recruited using cluster sampling. FSW aged 16 years above who completed questionnaire testing....
In China, rural areas are a weak link of HIV/AIDS prevention and control. From September 2011, an innovative "county-township-village" allied intervention was implemented in Longzhou County, Guangxi, which assigned the tasks control to county Centers for Disease Control Prevention (CDC), township hospitals, village clinics, respectively, instead traditional CDC undertook entire work. A 6-year consecutive cross-sectional survey, including 3-year (2009–2011) (2012–2014), conducted evaluate...
Abstract Objective To evaluate the impact of AIDS-defining events (ADE) on long-term mortality HIV positive individuals antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study performed in Southwestern China. Methods The was conducted among 6757 patients ART (2NRTIs + 1NNRTI, 2NRTIs 1PI and Single or two drugs) recruited Guigang city, Guangxi, China, from January 2004 to December 2018. Participants were divided into ADE non-ADE groups, followed-up every six months...
Background: CD4/CD8 ratio is considered as an emerging biomarker for human immunodeficiency virus (HIV)-related diseases. However, the relationship of recovery and chronic kidney disease (CKD), whether cumulative antiretroviral therapy (ART) effective in reducing CKD incidence among HIV patients remain unclear. Methods A 17-year observational cohort study was conducted on all HIV-infected receiving ART Guangxi, China. Kaplan–Meier analysis used to investigate incidence. Cox regression...
Alcohol could compromise the anti-hepatitis C virus (HCV) function of interferon-alpha (IFN-α). However, little information is available about effect alcohol on interferon-lambda (IFN-λ, type III IFN), a novel candidate for development therapy HCV infection. Huh7 cells were infected with JFH-1 virus, then treated alcohol, and/or IFN-λ1. RT-PCR and Western blot used to detect levels key cellular factors. Overexpression or silencing expression was performed verify role factors in...
Abstract Background Talaromyces marneffei (formerly Penicillium ) is an important thermally dimorphic fungus endemic which characterized by one of the most frequent opportunistic infections in HIV/AIDS patients, mainly prevalent Southeast Asia, southern China, and northeastern India. Cotrimoxazole(CTX) inhibits folic acid synthesis for survival many bacteria, protozoa, fungi, thereby commonly used to prevent several among patients. In addition preventing other HIV-associated infections, CTX...
Introduction K-41A is a known compound with antibacterial activity against gram-positive bacteria and coccidia. In our screening of anti-HIV compounds, we found polyether antibiotic its analogue K-41Am isolated from marine-derived Streptomyces sp. SCSIO 01680 exhibited activity. Material methods this study, characterised the as well mechanism(s) involved. The dose-dependent inhibitory effects on HIV-1 replication were observed in TZM-bl-HIV-1IIIB system, MT-2-HIV-1IIIB peripheral blood...
Little is known about pre-exposure prophylaxis (PrEP) awareness and willingness among male rural-to-urban migrant workers, a high-risk population of HIV infection transmission in China. The aim this study was to assess the use PrEP vulnerable two cities Guangxi Zhuang autonomous region, province southwestern A cross-sectional survey conducted workers province, during June August, 2015. Multivariable logistic regression analysis used examine factors related acceptance. Among 669 surveyed,...
Abstract Background Vaccination is the most effective approach against coronavirus disease 2019 (COVID-2019) pandemic. This study aimed to investigate acceptance and predominant influential factors of COVID-19 vaccination among people living with human immunodeficiency virus (HIV)/acquired syndrome (AIDS). Methods A cross-sectional survey was carried out in five cities Guangxi from 7 May 1 June 2021. Questionnaires on were conducted HIV/AIDS patients recruited by random cluster sampling. We...
Abstract Objective: To evaluate the impact of AIDS-defining events (ADE) on long-term mortality HIV positive individuals antiretroviral therapy (ART), a retrospective HIV/AIDS treatment cohort study performed in Southwestern China. Methods: The was conducted among 6757 patients ART (2NRTIs+1NNRTI, 2NRTIs+1PI and Single or two drugs) recruited Guigang city, Guangxi, China, from January 2004 to December 2018. Participants were divided into ADE non-ADE groups, followed-up every six months...
<sec> <title>BACKGROUND</title> Background: Since more HIV-infected people are living longer, it is crucial to monitor the number of non-AIDS-related events, especially liver diseases. Liver-related deaths in patients occur often comparison with general population. The CD4/CD8 ratio considered an emerging biomarker for events. However, current research was rarely designed investigate connection between and certain types particularly damage. </sec> <title>OBJECTIVE</title> Objective: aim this...
Background: As the life expectancy of individuals infected with HIV continues to increase, vigilant monitoring non-AIDS-related events becomes imperative, particularly those pertaining liver diseases.In comparison general population, patients experience a higher frequency liver-related deaths.The CD4/CD8 ratio is emerging as potential biomarker for events.However, few existing studies have been specially designed explore relationship between and specific types events, notably...