Sevoflurane, an inhalational general anesthetic, has become one of the most widely used anesthetics in surgery. However, previous studies have found that sevoflurane anesthesia can trigger inflammatory response, resulting secondary damage. Dexmedetomidine (DEX), a highly-selective α adrenergic receptor agonist, is as anesthetic adjuvant clinic. In this study we investigated whether DEX was able to suppress sevoflurane-induced neuroinflammation.The aim determine mechanism action suppressive...

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Postoperative cognitive dysfunction (POCD) is a common complication in the postoperative nervous system of elderly patients. Surgery-induced hippocampal neuroinflammation closely associated with POCD. Dexmedetomidine (DEX) an effective α2-adrenergic receptor agonist, which can reduce inflammation and has neuroprotective effects, thereby improving dysfunction. However, mechanism by DEX improves POCD currently unclear. The purpose present study was therefore to identify how acted on Male...

Dexmedetomidine (DEX) is a selective agonist of α2-adrenergic receptors with anesthetic activity and neuroprotective benefits. However, its mechanism action at the molecular level remains poorly defined. In this study, we investigated protective effects DEX on oxygen-glucose deprivation/ reperfusion (OGD/R)-induced neuronal apoptosis in PC12 cells, evaluated underlying mechanism(s) neuroprotection anti-inflammation.

Objective: The objective of this study was to observe the effect Yangxinshi tablets on phenotype and function peripheral blood monocytes in patients with unstable angina coronary heart disease (CHD) explore possible mechanism treatment CHD. Methods: A total 100 CHD were randomly divided into two groups: Group – group B control group. phenotypic functional changes serum inflammatory factors before after compared groups. Results: expression CD14+CD163+ interleukin (IL)-10+ significantly higher...

Abstract Background: In advanced non-small cell lung cancer(NSCLC) with epidermal growth factor receptor (EGFR) gene mutations, the receptor-tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved patient prognosis. The third-generation EGFR-TKI, Osimertinib, has become standard first-line treatment. recent years, some studies suggested that Osimertinib may carry a higher risk of developing venous thromboembolism (VTE) in real world. There been related cases inducing thrombus...

Anesthesia-induced neurotoxicity may cause permanent dysfunctions in human brains. In this work, we used a cell-based in-vitro model to demonstrate that traditional Chinese medicine, Kami-Shoyo-San protect ketamine-induced neuronal apoptosis embryonic stem cell-differentiated neurons.Human neurons were cultured vitro and treated with high-concentration ketamine induce apoptosis. Pre-incubation of was conducted evaluate its neuroprotection on ketamine-injured neurons. Quantitative real-time...

Abstract Background Dexmedetomidine (DEX) is a selective agonist of α2-adrenergic receptors with anesthetic activity and neuroprotective benefits. However, its mechanism action at the molecular level remains poorly defined. In this study, we investigated protective effects Dex on OGD/R-induced neuronal apoptosis in PC12 cells, evaluated underlying mechanism(s) neuroprotection anti-inflammation.Methods An OGD/R model cells was established. were cultured vitro divided into control, OGD/R, +...

Abstract Background: Sevoflurane, an inhalational general anesthetic, has become one of the most widely used anesthetics in surgery. However, previous studies have found that sevoflurane anesthesia can trigger inflammatory response, resulting secondary damage. Dexmedetomidine (DEX), a highly-selective α adrenergic receptor agonist, is as adjuvant drug clinic. Here, we investigate whether DEX suppress anesthesia-induced neuroinflammation. Methods: We sought to determine mechanism action this...