A5101572628- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- RNA Research and Splicing
- Advanced Radiotherapy Techniques
- Neutropenia and Cancer Infections
- Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Reconstructive Surgery and Microvascular Techniques
- Neuroblastoma Research and Treatments
- Metastasis and carcinoma case studies
- Signaling Pathways in Disease
- Vascular Malformations and Hemangiomas
- Surgical site infection prevention
- Breast Lesions and Carcinomas
- RNA regulation and disease
- Gastrointestinal Bleeding Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Central Venous Catheters and Hemodialysis
First Affiliated Hospital of Zhengzhou University
2015-2024
Zhengzhou University
2015-2021
First Bethune Hospital of Jilin University
2021
Fudan University Shanghai Cancer Center
2019
Shanghai Medical College of Fudan University
2019
Changhai Hospital
2016
Second Military Medical University
2016
Abstract Background Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of resistance. Recent evidence suggests that long noncoding RNAs (lncRNAs) play important roles in tumorigenesis and chemoresistance. However, regulatory mechanism lncRNAs resistance is not well established to date. In this research, we identified differentially expressed lncRNA investigated its role cancer. Methods LncRNA microarray qRT-PCR...
The long non-coding RNA (lncRNA) has recently been shown to be important regulators involved in the progression of various human cancers. Small nucleolar host gene 6 (SNHG6) is a identified cancer-related lncRNA. However, clinical significance and biological function SNHG6 breast cancer (BC) are still unclear. In present study, we found that was highly expressed BC tissues cell lines, which associated with poorer clinicopathologic features. Knockdown inhibited proliferation, migration...
Long non-coding RNAs (lncRNAs) were found to regulate many biological processes including cancer development, immunology and other diseases. LncRNA HULC was be oncogenes in progression. However, the role of regulation breast remains unclear.The expression miR-6754-5p examined by RT-PCR. Through knockdown HULC, we that proliferation abilities coupled with migration invasion significantly decreased. And also, verified overexpression decreased ability cells.In this study, lncRNA overexpressed...
Breast cancer is a one of the most malignant threats among women worldwide. However, mechanism underlying breast development remains unclear. Long noncoding RNAs (lncRNAs) have been reported to participate in cancer. Whether lncRNA LINC01857 involved requires investigation. In this study, we found that was highly expressed tissues and cells (p < 0.05). High expression predicted poor prognosis patients. Functionally, silencing impaired proliferation enhanced apoptosis ( p Decreased inhibited...
// Fang Wang 1, * , Pengwei Lv Yuanting Gu 1 Lin Li Xin Ge Guangcheng Guo Department of Breast Surgery, The First Affiliated Hospital Zhengzhou University, 450000, China These authors have contributed equally to this work Correspondence to: Li, email: huangjinlingv@sina.com Keywords: Galectin-1, multidrug resistance, P-glycoprotein, Raf-1/AP-1, breast cancer Received: October 19, 2016 Accepted: January 16, 2017 Published: February...
Breast cancer is a serious threat to women's physical and psychological health. Long noncoding RNA CAMTA1 (lncCAMTA1) was believed be related with tumor progression, but its role in breast not clear. The human cell line MDA-MB-231 used investigate the effect of lncCAMTA1 on viability, migration/invasion, apoptosis. expression lncCAMTA1, miR-20b,
Abstract Background This prospective study aims to investigate the efficacy and safety of pyrotinib (P) combined with 4 cycles epirubicin cyclophosphamide followed by taxane trastuzumab (P + EC-TH) regimen as neoadjuvant therapy for human epidermal growth factor receptor 2 (HER2) positive breast cancer predictive value p53, p63, (EGFR) status efficacy. Methods A total 138 HER2-positive patients who received underwent surgery were included. Case group: 55 P EC-TH regimen. Control 83 The...
Accumulating evidence has reported the significant role of miRNAs in underlying biology tumors, including breast cancer. The purpose for this study was to investigate potential effects miR-544a cancer migration and invasion. human normal Hs578Bst cells MCF-7 MDA-MB-231 were used analyze expression by RT-PCR. on two kinds cell invasion analyzed using Matrigel Transwell assay, respectively. metastasis-related protein also Western blotting. Compared cells, significantly downregulated but...
Totally implantable venous access port system (TIVAPS) is widely used in breast cancer therapy; TIVAPS has several associated complications depending on the depth of implantation (BC) patients during continuous infusional chemotherapy regimens. The purpose this study to find out optimal reduce incidence chemotherapy.This reviewed internal jugular vein 1282 over a ten-year period (2009-2019), and complications. We segregated as 5 groups: 'Group A (depth < 4 mm), Group B 4-8 C 8-12 D 12-16 E >...
Plasmacytoma variant translocation 1 (PVT1) expression was elevated in breast cancer tissues and correlated to progression prognosis.
Linc00472 expression was down-regulated in breast cancer tissues and cells, associated with the development prognosis of cancer.
Objective To investigate the clinical application value of magnetically guided capsule endoscopy (MGCE) to stomach examination. Methods Data 500 patients who received MGCE examination from January 2014 February 2016 in our hospital were retrospectively analyzed. The feasibility and safety studied by analyzing detection rate gastric lesions, transit time, adverse events, clarity visibility, comparison with esophagogastroduodenoscopy(EGD). Results The lesion detecting was...
Background: Breast cancer (BC) is a malignant tumor with the highest morbidity among women, disrupting millions of their lives worldwide each year. However, molecular mechanisms underlying remain unclear. Materials and Methods: The RNA-Sequencing clinical data BC patients from Cancer Genome Atlas (TCGA) database were analyzed by weighted gene coexpression network analysis (WGCNA). Additionally, coexpressed modules used to detect correlation traits BC. Next, nodes most significant for Gene...
Abstract Background: CDK4/6 inhibitors effectively block tumor cells from progressing the G1 phase to S phase, thereby interrupting cell cycle progression and inhibiting proliferation. Dalpiciclib is a novel inhibitor developed independently in China, which has been approved for use combination with fulvestrant treatment of HR-positive/HER2-negative recurrent or metastatic breast cancer patients who have experienced disease after prior endocrine therapy, aromatase as initial locally advanced...
Background: As one of the main malignant tumors affecting women, incidence breast cancer increases year by year. This study aims to analyze risk factors infection in patients during postoperative chemotherapy measuring changes levels T lymphocytes and inflammatory peripheral blood. Methods: The clinical data 156 who underwent radical mastectomy [docetaxel, epirubicin, cyclophosphamide (TEC)] our hospital from May 2014 April 2018 were retrospectively analyzed. According presence or absence...