Conghui Qu
A5088911424- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Meat and Animal Product Quality
- Nutritional Studies and Diet
- Colorectal Cancer Treatments and Studies
- Digestive system and related health
- Cancer Genomics and Diagnostics
- Vitamin D Research Studies
- Estrogen and related hormone effects
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- BRCA gene mutations in cancer
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Plant-based Medicinal Research
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Molecular Biology Techniques and Applications
- Culinary Culture and Tourism
- Phytoestrogen effects and research
Fred Hutch Cancer Center
2016-2025
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2013-2023
Cancer Research Center
2023
Binus University
2023
Harvard University
2013-2023
USC Norris Comprehensive Cancer Center
2018
Faculty of Public Health
2018
University of Washington
2014
Brigham and Women's Hospital
2013
Massachusetts General Hospital
2013
IMPORTANCEUse of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk colorectal cancer.OBJECTIVE To identify common genetic markers that may confer differential benefit from or NSAID chemoprevention, we tested gene × environment interactions between regular use and/or NSAIDs single-nucleotide polymorphisms (SNPs) in relation to cancer. DESIGN, SETTING, AND PARTICIPANTSCase-control study using data 5 case-control cohort studies initiated 1976 2003...
Abstract Background Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub-site or sex is unclear. Further, metabolic alterations mediating effects on CRC are not fully understood. Methods We examined sex- and site-specific associations with adiposity-associated metabolites explain CRC. Genetic variants from genome-wide association studies body mass index (BMI) waist-to-hip ratio (WHR, unadjusted for BMI; N = 806,810), 123...
Background & AimsHuman studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and binding protein 3 (IGFBP3) colorectal cancer risk have reported inconsistent results. We conducted complementary serologic Mendelian randomization (MR) analyses to determine whether alterations in IGF1 or IGFBP3 are associated with development.MethodsSerum were measured blood samples collected from 397,380 participants the UK Biobank, 2006 through 2010. Incident cases...
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional significantly mutated find that among hypermutated tumors, an increased mutation burden associated improved CRC-specific (HR = 0.42, 95% CI:...
Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact genetic variants modify risk of cancer. We tested interactions between approximately 2.7 million for cancer among 9,287 cases 9,117 controls from ten studies. used logistic regression investigate multiplicative gene-diet interactions, well our recently developed Cocktail method that involves a screening step...
Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting pathogenic role intestinal microbiome, which gradually changes across entire length, prevalence certain tumor molecular characteristics along subsites. Understanding how features differ by and location is important in personalized patient management.
Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors impute expression perform gene-level tests in GWAS without directly measured transcriptomes. In this study, we used reference datasets from colon (n = 169) whole blood 922) transcriptomes test CRC with genetically...
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Abstract Carriers of germline biallelic pathogenic variants in the MUTYH gene have a high risk colorectal cancer. We test 5649 cancers to evaluate discriminatory potential tumor mutational signature specific for identifying carriers and classifying uncertain clinical significance (VUS). Using matched targeted multi-gene panel approach, our classifier identifies all known non-carriers an independent set 3019 (accuracy = 100% (95% confidence interval 99.87–100%)). All monoallelic are...
Abstract The role of the human gut microbiome in colorectal cancer (CRC) is unclear as most studies on topic are unable to discern correlation from causation. We apply two-sample Mendelian randomization (MR) estimate causal relationship between and CRC. used summary-level data independent genome-wide association effect 14 microbial traits (n = 3890 individuals) overall CRC (55,168 cases, 65,160 controls) site-specific risk, conducting several sensitivity analyses understand nature results....
Abstract Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher undertake targeted screening. However, current PRS using European ancestry data sub-optimal performance in non-European populations, limiting their utility among these populations. Towards addressing this deficiency, we expand development for CRC incorporating Asian (21,731 cases; 47,444 controls) into training datasets (78,473 107,143 controls). The...
The prevalence of vasomotor symptoms (VMS) among women aged 45 years or older who report regular menses has not been described well. Variability by race/ethnicity is expected.A cross-sectional analysis Group Health enrollees was performed ages 45-56 y with and no skipped menses, taking hormones. Data were collected from electronic databases mailed surveys, including a soy food questionnaire. Associations between VMS (ever/never; past 2 wk) assessed using generalized linear models,...
This study aims to evaluate the associations of vasomotor symptom (VMS) frequency, bother, and severity with equol producer status dietary daidzein intake.This is an observational study. included women aged 45 55 years, in postmenopause or menopausal transition, who had soy food intake three more servings per week. Exclusion criteria severe concurrent disease, pregnancy planned pregnancy, current use oral transdermal hormones selective estrogen receptor modulators. After screening, 375...
Abstract Background Obesity is an established risk factor for colorectal cancer (CRC), but the evidence association inconsistent across molecular subtypes of disease. Methods We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype BRAF and KRAS mutations, Jass classification types 11 872 CRC cases 013 controls from observational studies. used multinomial logistic regression to estimate odds ratios (OR) 95% confidence intervals (CI)...