A5055597403- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Potassium and Related Disorders
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Diabetes Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Ultrasound in Clinical Applications
- Neurological disorders and treatments
- Sodium Intake and Health
- Acute Myocardial Infarction Research
Onze Lieve Vrouwziekenhuis Hospital
2024-2025
Ziekenhuis Oost-Limburg
2019-2024
AZ Sint-Lucas
2023-2024
Hasselt University
2019-2024
KU Leuven
2014-2020
Cleveland Clinic
2020
Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated heart failure volume overload, is unclear.
Background: The use of urinary sodium to guide diuretics in acute heart failure is recommended by experts and the most recent European Society Cardiology guidelines. However, there are limited data support this recommendation. ENACT-HF study (Efficacy a Standardized Diuretic Protocol Acute Heart Failure) investigated feasibility efficacy standardized natriuresis-guided diuretic protocol patients with signs volume overload. Methods: was an international, multicenter, open-label, pragmatic,...
Abstract Aims Iron deficiency is common in heart failure with reduced ejection fraction (HFrEF) and negatively affects cardiac function structure. The study the effect of ferric carboxymaltose (FCM) on reverse remodelling contractile status HFrEF. Methods results Symptomatic HFrEF patients iron a persistently left ventricular (LVEF <45%) at least 6 months after resynchronization therapy (CRT) implant were prospectively randomized to FCM or standard care (SOC) double-blind manner....
In the ADVOR trial, acetazolamide improved decongestion in acute decompensated heart failure (ADHF). Whether beneficial effects of are consistent across entire range renal function remains unclear.
Acetazolamide inhibits proximal tubular sodium and bicarbonate re-absorption improved decongestive response in acute heart failure the ADVOR trial. It is unknown whether levels alter to acetazolamide.This a sub-analysis of randomized, double-blind, placebo-controlled trial that randomized 519 patients with volume overload 1:1 ratio intravenous acetazolamide (500 mg/day) or matching placebo on top standardized loop diuretics (dose equivalent twice oral maintenance dose). The primary endpoint...
This study aimed to investigate incidence and predictors of weaning failure in-hospital death after successful from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS). Overall, 685 CS treated VA-ECMO 23 tertiary care centres 7 countries were analysed (median age 57 [interquartile range 49-66] years, 542 [79.1%] male, median lactate 7.6 4.1-12.7] mmol/L). The cause was acute myocardial infarction 438 (63.9%) patients, 431 (62.9%) presented...
Despite its high incidence and mortality risk, there is no evidence-based treatment for non-ischaemic cardiogenic shock (CS). The aim of this study was to evaluate the use mechanical circulatory support (MCS) CS treatment.In multicentre, international, retrospective study, data from 890 patients with CS, defined as due severe de-novo or acute-on-chronic heart failure need urgent revascularization, treated without active MCS, were collected. association between MCS primary endpoint 30-day...
Aims To explore the effects of dapagliflozin on congestion through CardioMEMS (Abbott Inc., Atlanta, USA) and Cordella™ pulmonary artery Sensor (Endotronix Lisle, Il, devices, which are implantable systems that provide real‐time remote monitoring pressure (PAP). Methods results Single‐centre open label observational pilot trial, to investigate short‐term in consecutive heart failure reduced ejection fraction patients with elevated PAP between October December 2019, previously implanted or...
We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared other cardiovascular and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). further wanted to determine incidence HF events and its consequences in these patient populations.International retrospective Postgraduate Course Heart Failure registry for COVID-19 CArdioVascular dyslipidaemia) was performed 28 centres from 15 countries (PCHF-COVICAV). The primary...
Although acute heart failure (AHF) with volume overload is treated loop diuretics, their dosing and type of administration are mainly based upon expert opinion. A recent position paper from the Heart Failure Association (HFA) proposed a step-wise pharmacologic diuretic strategy to increase response achieve rapid decongestion. However, no study has evaluated this protocol prospectively.
Background: Acetazolamide inhibits proximal tubular sodium reabsorption and improved decongestion in the ADVOR (Acetazolamide Decompensated Heart Failure with Volume Overload) trial. It remains unclear whether decongestive effects of acetazolamide differ across spectrum left ventricular ejection fraction (LVEF). Methods: This is a prespecified analysis randomized, double-blind, placebo-controlled trial that enrolled 519 patients acute heart failure (HF), clinical signs volume overload (eg,...
Aims Heart failure‐related cardiogenic shock (HF‐CS) accounts for a significant proportion of CS cases. Whether patients with de novo HF and those acute‐on‐chronic in differ clinical characteristics outcome remains unclear. The aim this study was to evaluate differences presentation mortality between HF‐CS. Methods results In international observational study, HF‐CS from 16 tertiary care centres five countries were enrolled 2010 2021. To investigate 30‐day mortality, adjusted logistic/Cox...
Chloride plays a crucial role in renal salt sensing. This study investigates whether serum chloride is associated with clinical outcomes and decongestive response to acetazolamide patients acute decompensated heart failure.