A5071335852- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Adipose Tissue and Metabolism
- Cardiac Valve Diseases and Treatments
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Neurological disorders and treatments
- Scoliosis diagnosis and treatment
- Regulation of Appetite and Obesity
- Renal Transplantation Outcomes and Treatments
- Spine and Intervertebral Disc Pathology
- Pregnancy and preeclampsia studies
- Cardiovascular Disease and Adiposity
- Ultrasound and Hyperthermia Applications
- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Muscle activation and electromyography studies
- Advanced MRI Techniques and Applications
- Polyomavirus and related diseases
- Business Process Modeling and Analysis
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2017-2025
Biotronik (Switzerland)
2020
Medtronic (Switzerland)
2020
Boston Scientific (Netherlands)
2020
Ziekenhuis Oost-Limburg
2011-2020
Abbott (Sweden)
2020
Medtronic (United States)
2020
Siemens (Hungary)
2017
Hospital Universitario Araba
2015
Development of vasculature and mRNA expression 17 pro- or antiangiogenic factors were studied during adipose tissue development in nutritionally induced genetically determined murine obesity models. Subcutaneous (SC) gonadal (GON) fat pads harvested from male C57Bl/6 mice kept on standard chow [standard diet (SFD)] high-fat for 0-15 wk ob/ob SFD. Ob/ob had significantly larger SC GON pads, accompanied by higher blood content, increased total vessel volume, number proliferating cells. protein...
In Brief Study Design. Retrospective study. Objective. To identify the prevalence of lumbar scoliosis in adults ≥40 years old; to investigate relationships between and 3 parameters (age, race, gender); determine any effect those on curve severity. Summary Background Data. As population ages, incidence degenerative spine conditions increases. More patients are being diagnosed with treated for spinal deformities, including scoliosis. Methods. We examined dual-energy x-ray absorptiometry images...
Deranged energy metabolism contributes to the pathophysiology of heart failure (HF). Recent studies showed diminished free fatty acid (FFA) oxidation in experimental HF models with a shift towards ketone bodies. However, conflicting clinical data on FFA and limited knowledge body human mandate additional metabolic profiling studies. We, therefore, investigated cardiac uptake FFAs bodies (β-hydroxybutyrate acetoacetate) patients reduced ejection fraction (HFrEF) or aortic stenosis...
Abstract Aims Left ventricular (LV) failure in left bundle branch block is caused by loss of septal function and compensatory hyperfunction the LV lateral wall (LW) which stimulates adverse remodelling. This study investigates if LW measured as myocardial work, alone combined with assessment viability, identifies responders to cardiac resynchronization therapy (CRT). Methods results In a prospective multicentre 200 CRT recipients, work was pressure-strain analysis viability magnetic...
Information on the prevalence, outcome and factors associated with heart failure in patients adult congenital disease (CHD) (ACHD-HF) is lacking. We aimed at assessing prevalence of ACHD-HF, variables differences between major anatomical/pathophysiological ACHD subgroups.We included 3905 (age 35.4 ± 13.2 years) under active follow-up our institution (last visit >2010). Outcome ACHD-HF cases was compared sex- age-matched cases. Univariable multivariable binary logistic regression diagnosis as...
Placental growth factor (PlGF)-deficient (PlGF-/-) and wild-type mice were kept on a standard-fat or high-fat diet for 15 weeks. With the diet, body weights of PlGF-/- comparable, whereas combined weight subcutaneous gonadal adipose tissues was lower in (P = 0.02). had < 0.05) less total plus tissue 0.0001). Blood vessel size with both 0.05). density, normalized to adipocyte number, significantly fed 0.01). De novo development nude injected 3T3-F442A preadipocytes reduced 0.005) by...
Contradicting reports have been published regarding the relation between a dobutamine-induced increase in either cardiac dyssynchrony or left-ventricular ejection fraction (LVEF) and response to resynchronization therapy (CRT). Using apical rocking (ApRock) as surrogate parameter, we investigated dobutamine stress echocardiography (DSE)-induced changes (LV) LVEF their potential pathophysiological interdependence. Fifty-eight guideline-selected CRT candidates were prospectively enrolled for...
Objective— The objective of this study was to investigate the role plasminogen activator inhibitor-1 (PAI-1) in adipose tissue development vivo. Methods and Results— Transgenic (Tg) mice overexpressing murine PAI-1 under control adipocyte promoter aP2 wild-type (WT) controls were kept on standard food (SFD) or high-fat diet (HFD) for 15 weeks. body weight isolated subcutaneous gonadal fat deposits Tg HFD significantly lower than those WT mice. number adipocytes similar HFD, but hypotrophy a...
To investigate a potential role of stromelysin-1 (MMP-3) in development adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on high fat diet (HFD) for 15 weeks. MMP-3(-/-) hyperphagic gained more weight than the MMP-3(+/+) mice. At time sacrifice, body was significantly higher that mice, as isolated subcutaneous (SC) gonadal (GON) deposits. Significant adipocyte hypertrophy observed GON but not SC tissue Fasting plasma glucose...
Clinical guidelines on implantable cardioverter defibrillator (ICD) therapy changed significantly in the last decades with potential inherent effects efficacy. We aimed to study rates time and association between therapies mortality.All patients receiving an ICD, primary secondary prevention, were included a single-center retrospective registry. Information first appropriate inappropriate was documented. Dates of implant divided P1: 1996-2001, P2: 2002-2008, P3: 2009-2014.A total 727...
Abstract Introduction Echocardiography-derived septal strain patterns stages are associated with a stepwise increase in survival for each increment stage among patients treated cardiac resynchronization therapy (CRT). However, it is unknown whether the could also predict conservatively-treated (i.e. not CRT-implanted) patients. Purpose This study aims to investigate interplay between and long-term both CRT- Methods In this multicentre study, CRT-eligible from six European centres underwent...
Abstract Introduction The Micra AV leadless pacemaker (model MC1AVR1, Medtronic, MN, US) provides atrio-ventricular (AV) synchronous pacing thanks to accelerometer-based mechanical sensing of the atrial contraction (A4 signal). device includes an automatic feature with auto-adjustment A4 threshold. To date, correlation between and manual measurements has not been studied in a real-world setting. Therefore, we aimed validate accuracy clinical relevance measurements. Purpose characterize (Auto...
Abstract Background Predicting response to cardiac resynchronization therapy (CRT) remains challenging. QRS-microfragmentation (QRSµf) and QRS non-planarity (QRSnp), novel ECG-derived parameters which quantify subtle abnormalities in ventricular depolarization, have emerged as potent predictors of adverse outcomes patients. Purpose To determine whether QRSµf QRSnp can predict clinical outcome left ejection fraction (LVEF) improvement CRT recipients. Methods In a single-center retrospective...
Abstract Background Since landmark trials conducted more than 2 decades ago, the implantable cardioverter defibrillator (ICD) has served as cornerstone in prevention of sudden cardiac death high-risk patients. Yet, recent improvements cardiovascular preventive care and heart failure treatment raise questions about role ICDs current clinical practice. Purpose To study evolution ICD-resistant mortality (ICDRM) ischemic dilated cardiomyopathy across different therapeutic eras. Methods All...
Abstract Introduction Stereotactic arrhythmia radioablation (STAR) has emerged as a novel treatment option for patients with ventricular tachycardia (VT) who are either refractory to or have contraindications standard therapies. Purpose To evaluate the efficacy of STAR in VT. Methods The CREVET study is single-centre, prospective investigating safety and treating Eligible participants aged ≥18 years structural heart disease experienced ICD therapy monomorphic VT adding escalating...
Abstract Aims Left bundle branch block (LBBB) septal strain patterns are associated with left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). However, their prognostic value and impact in patients undergoing CRT, as well CRT-eligible receiving conservative treatment remains underexplored. This study aimed to validate the significance of LBBB elucidate mechanisms underlying CRT response by evaluating interaction myocardial scar clinical outcomes. Methods...
Abstract Aims Left bundle branch pacing (LBBP) has been shown to better maintain electrical synchrony compared with right ventricular (RVP), but little is known about its impact on mechanical synchrony. This study investigates whether LBBP preserves left (LV) synchronicity and function RVP. Methods results Sixty patients indication for bradycardia were included: (n = 31) RVP 29). Echocardiography was performed before shortly after pacemaker implantation at 1-year follow-up. The lateral...