A5004076364- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Cardiovascular Disease and Adiposity
- Viral Infections and Immunology Research
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Atomic and Subatomic Physics Research
- Advanced X-ray and CT Imaging
- Congenital heart defects research
- Williams Syndrome Research
- Medical Imaging Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Cardiac Health and Mental Health
- Neurogenetic and Muscular Disorders Research
- Advancements in Battery Materials
- Trypanosoma species research and implications
- Obstructive Sleep Apnea Research
University Health Network
2015-2024
Toronto General Hospital
2015-2024
Centre for Advancing Health Outcomes
2024
Health Net
2024
University of Toronto
2008-2023
Rambam Health Care Campus
2023
Beth Israel Deaconess Medical Center
2012-2022
Harvard University
2001-2020
Cardiovascular Research Center
2020
Minneapolis Heart Institute Foundation
2012-2017
Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden death in young, although not all patients eligible for prevention with an implantable cardioverter-defibrillator are identified. Contrast-enhanced cardiovascular magnetic resonance late gadolinium enhancement (LGE) has emerged as vivo marker myocardial fibrosis, its role stratifying risk subgroups HCM remains incompletely understood.We assessed relation between LGE and outcomes 1293 referred followed up a median 3.3 years....
Background— Hypertrophic cardiomyopathy (HCM) is prominently associated with risk for sudden death and disease progression, largely in young patients. Whether patients of more advanced age harbor similar risks unresolved, often creating clinical dilemmas, particularly decisions primary prevention implantable defibrillators. Methods Results— We studied 428 consecutive HCM presenting at ≥60 years followed 5.8±4.8 years; 53% were women. Of the patients, 279 (65%) survived to 73±7 (range, 61–96...
In hypertrophic cardiomyopathy (HCM), cardiovascular MR can detect morphological abnormalities of the left ventricle (LV) not visualized with echocardiography. Although myocardial crypts (ie, narrow, blood-filled invaginations within LV wall) have been recognized in HCM, all clinical implications these structural broad HCM spectrum are completely resolved. Therefore, we sought to characterize prevalence and diagnostic significance patients.Cine late gadolinium enhancement 2-dimensional...
The genetic basis of hypertrophic cardiomyopathy (HCM) is complex, and the relationship between genotype status clinical outcome incompletely resolved.
Background— In hypertrophic cardiomyopathy (HCM), heart transplant has been predominantly confined to patients with systolic dysfunction. An underappreciated HCM subset comprises preserved left ventricular (LV) function who may also require consideration for transplantation. Therefore, we sought define the clinical profile and occurrence of advanced failure among nonobstructive function. Methods Results— Databases from 2 referral centers comprising 2100 were interrogated. Forty-six (2.2%)...
To evaluate the use of low-dimensional-structure self-learning and thresholding (LOST) compressed sensing acquisition reconstruction in assessment left atrial (LA) ventricular (LV) scar by using late gadolinium enhancement (LGE) magnetic resonance (MR) imaging with isotropic spatial resolution.The study was approved local institutional review board compliant HIPAA. All subjects provided written informed consent. Twenty-eight patients (eight women; mean age, 58.0 years ± 10.1) a history...
We sought to compare maximal left ventricular (LV) wall thickness (WT) measurements as obtained by routine clinical practice between echocardiography and cardiac magnetic resonance (CMR) document causes of discrepancy.One-hundred ninety-five patients with hypertrophic cardiomyopathy (median age, 52.8±15.1 years) who underwent CMR imaging within 6 months (median, 41 days; interquartile range, 16-97 days) were included. LVWT was assessed in parasternal long short axis 2-dimensional CMR. By...
Cardiovascular magnetic resonance (CMR) has improved diagnostic and management strategies in hypertrophic cardiomyopathy (HCM) by expanding our appreciation for the diverse phenotypic expression. We sought to characterize prevalence clinical significance of a recently identified accessory left ventricular (LV) muscle bundle extending from apex basal septum or anterior wall (i.e. apical–basal). CMR was performed 230 genotyped HCM patients (48 ± 15 years, 69% male), 30...
Purpose To enable accelerated isotropic sub‐millimeter whole‐heart coronary MRI within a 6‐min acquisition and to compare this with current state‐of‐the‐art imaging technique at acceleration rates beyond what is used clinically. Methods Coronary still faces major challenges, including lengthy time, low signal‐to‐noise‐ratio (SNR), suboptimal spatial resolution. Higher resolution in the range desirable, but results increased time lower SNR, hindering its clinical implementation. In study, we...
Background Cardiac MRI late gadolinium enhancement (LGE) scar volume is an important marker for outcome prediction in patients with hypertrophic cardiomyopathy (HCM); however, its clinical application hindered by a lack of measurement standardization. Purpose To develop and evaluate three-dimensional (3D) convolutional neural network (CNN)-based method automated LGE quantification HCM. Materials Methods We retrospectively identified data multicenter (n = 7) multivendor 3) HCM study obtained...
Disopyramide is effective in ameliorating symptoms patients with hypertrophic cardiomyopathy; however, its potential for proarrhythmic effect has raised concerns about use the ambulatory setting. The risk of initiating disopyramide this manner never been evaluated.All charts seen outpatient cardiomyopathy clinic between 2010 and 2014 were screened initiation data extracted. our usually initiated at a dose 300 mg daily titrated during follow-up. A total 2015 clinic, including 168 who started...
Background— The aim of the study was to clarify relationship between genotype status and major cardiovascular outcomes in a large cohort patients with hypertrophic cardiomyopathy. Methods Results— Genetic testing performed 558 consecutive proband Baseline follow-up (mean 6.3 years) clinical echocardiographic data were obtained. Pathogenic mutations identified 198 (35.4%) patients. Genotype-positive more likely be women (44% versus 30%; P =0.001), younger (39 48 years; <0.001), have family...