A5079568493- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Hormonal Regulation and Hypertension
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Nitric Oxide and Endothelin Effects
- Cardiac electrophysiology and arrhythmias
- Blood properties and coagulation
- Erythropoietin and Anemia Treatment
- Cardiovascular Health and Disease Prevention
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Hospital Admissions and Outcomes
- Sleep and Work-Related Fatigue
- Cardiac Ischemia and Reperfusion
Abbott Northwestern Hospital
2014-2024
Minneapolis Heart Institute Foundation
2012-2024
Allina Health
2021-2024
Hennepin County Medical Center
2018
Minneapolis Institute of Arts
2016
Beth Israel Deaconess Medical Center
2014
Baylor University Medical Center
2014
Tufts Medical Center
2014
Yale University
2002-2010
Columbia University
2003-2005
Anemia frequently occurs in chronic heart failure (CHF) patients and is associated with a poor prognosis. A low hematocrit may result from an increased plasma volume (hemodilution) or reduced red blood cell (true anemia). The prevalence clinical outcome of CHF hemodilution unknown.The anemia its effect on was examined 196 CHF. assessed subset 37 ambulatory anemic I131-tagged albumin to measure volume. Clinical monitored. Sixty-one percent the were anemic. 33% New York Heart Association class...
Background— Endothelial function is known to be impaired in subjects with chronic heart failure (CHF), but the association between endothelial and subsequent mortality risk CHF has not been previously reported. Methods Results— Biomarkers of systemic arterial circulation (flow-mediated dilation [FMD] brachial artery) pulmonary (exhaled nitric oxide [NO] production during submaximal exercise) were prospectively assessed 259 New York Heart Association class II–III CHF. In FMD measurements...
Systemic anticoagulation is a standard of care in adult patients supported by extracorporeal membrane oxygenation (ECMO) to prevent circuit thrombosis and subsequent thromboembolic events. Unfractionated heparin has long been considered the anticoagulant choice, but emerging evidence reports successful ECMO runs with direct thrombin inhibitors. This retrospective study sought determine whether bivalirudin offers distinct clinical benefits as choice ECMO. Primary end points included...
Background— In hypertrophic cardiomyopathy (HCM), heart transplant has been predominantly confined to patients with systolic dysfunction. An underappreciated HCM subset comprises preserved left ventricular (LV) function who may also require consideration for transplantation. Therefore, we sought define the clinical profile and occurrence of advanced failure among nonobstructive function. Methods Results— Databases from 2 referral centers comprising 2100 were interrogated. Forty-six (2.2%)...
Abstract Aims Despite increased temporary mechanical circulatory support (tMCS) utilization for acute myocardial infarction complicated by cardiogenic shock (AMI-CS), data regarding efficacy and optimal timing tMCS are limited. This study aimed to describe outcomes based on in AMI-CS identify predictors of 30-day mortality readmission. Methods results Patients with identified the National Readmissions Database were grouped according use early (<24 h) vs. delayed (≥24 tMCS. The...
The current investigation was undertaken to determine the effects of active versus passive recovery on work performance during repeated bouts supramaximal exercise. Six healthy sedentary subjects and 9 moderately trained hockey players performed serial 30-second Wingate anaerobic power tests (WAnT) a bicycle ergometer interposed with 4 minutes at rate corresponding 28 % V·O2max or rest. Peak power, mean total achieved, fatigue index were calculated for WAnT. Capillary blood lactate...
ACE (angiotensin-converting enzyme) inhibitors and PDE5 (phosphodiesterase type 5) have each been reported to improve endothelial function in cardiovascular disease patients, but the comparative combined effects of these two classes not studied previously. We sought characterize acute ramipril alone, sildenafil or their combination on patients with CHF (chronic heart failure). subjects (n=64) were randomized receive placebo, 10 mg 50 alone a double-blind manner. FMD (flow-mediated dilation)...
Mortality due to refractory cardiogenic shock (RCS) exceeds 50%. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has become an accepted therapy for RCS. The aim of our study was evaluate outcomes patients with RCS treated percutaneous VA-ECMO (pVA-ECMO). Retrospective review supported at institution in 2012-2013. Clinical characteristics, bleeding, vascular complications, and including survival were assessed. A total 37 majority (76%) placed the catheterization laboratory. Nearly...
Background— Adrenergic receptor blockers used in the treatment of heart failure have distinct affinity profiles. We hypothesized that α-adrenergic–blocking effects carvedilol would limit vasoconstriction response to adrenergic stimuli when compared with metoprolol. Methods and Results— Forearm vascular resistance responses isometric handgrip cold pressor test were determined by plethysmography before during blockade prospective randomized trials. Acute assessed a crossover trial normal...
Pheochromocytomas are rare neuroendocrine tumors usually associated with severe or intermittent hypertension. derive from chromaffin cells of the sympathetic nervous system and produce excess amounts catecholamines, which responsible for hypertensive surges, palpitations, headache, diaphoresis commonly found these tumors. Less commonly, pheochromocytomas result in hypotension cyclic hypertension hypotension. We report a case pheochromocytoma presenting pulmonary hemorrhage hemoptysis,...
Right ventricular failure (RVF) is a significant cause of mortality in patients undergoing left assist device (LVAD) implantation. Although right devices (RVADs) can treat RVF the perioperative LVAD period, liberal employment before not well established. We therefore compared survival outcomes between proactive RVAD placement at time implantation with bailout strategy RVF. Retrospectively, 75 adult who underwent durable our institution and had an placed proactively or as postoperatively due...
Although current studies support the use of prophylactic distal perfusion catheters (DPCs) to decrease limb ischemia in patients on venoarterial extracorporeal membrane oxygenation (VA ECMO), methods for monitoring differ between studies. We evaluated safety a selective rather than DPC strategy at single center with well-established protocol monitoring. Distal were placed selectively if there was evidence hypoperfusion any point until decannulation. All followed daily by vascular surgery...
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) has been increasingly used in cardiopulmonary resuscitation (ECPR) select patients. Few centers have published their experience or outcomes with ECPR. The aim of our study was to evaluate adult patients cardiac arrest placed on VA ECMO the catheterization laboratory.We performed a retrospective analysis refractory who underwent ECPR at Minneapolis Heart Institute (MHI) Abbott Northwestern Hospital from January 2012 December 2017....
In patients treated for refractory cardiogenic shock (RCS) following acute myocardial infarction (AMI), predicting successful weaning from veno-arterial extracorporeal membrane oxygenation (VA ECMO) has important implications decision-making and prognosis.We performed a retrospective review of adult VA ECMO with RCS complicating AMI at our institution 2010 to 2019. We evaluated use peak troponin I as predictor decannulation.Sixty-two were analyzed; mean age 61.1 ± 9.8 years, 73% males, 62%...