A5044785782- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- NMR spectroscopy and applications
- Hemoglobinopathies and Related Disorders
- Electron Spin Resonance Studies
- Medical Image Segmentation Techniques
- Iron Metabolism and Disorders
- EEG and Brain-Computer Interfaces
- Blind Source Separation Techniques
- Atomic and Subatomic Physics Research
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound Imaging and Elastography
- Neural dynamics and brain function
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Solid-state spectroscopy and crystallography
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- ECG Monitoring and Analysis
- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Computer Graphics and Visualization Techniques
- Spectroscopy and Chemometric Analyses
Istituto di Fisiologia Clinica
2016-2025
Fondazione Toscana Gabriele Monasterio
2012-2024
National Research Council
2013-2024
Ospedale Regina Margherita
2017
Regione Toscana
2011-2016
Czech Academy of Sciences, Institute of Physiology
1997-2013
I.R.C.C.S. Oasi Maria SS
2008-2011
Policlinico Tor Vergata
2011
University of Pisa
1991-2010
National Academies of Sciences, Engineering, and Medicine
2003-2010
Abstract Purpose To assess the tissue iron concentration of left ventricle (LV) using a multislice, multiecho T2* MR technique and segmental analysis. Materials Methods MRI was performed in 53 thalassemia major patients. Three short‐axis views LV were obtained analyzed with custom‐written software. The myocardium automatically segmented into 12 segments. value on each segment as well global calculated. Cine dynamic images also to evaluate biventricular function parameters by quantitative...
To describe and evaluate an automatic unsupervised method for assessing the quantity distribution of abdominal adipose tissue by MRI.A total 20 patients underwent whole-abdomen MRI. A 32 transverse T1-weighted images were acquired from each subject. The data collected transferred to a dedicated workstation analyzed both our manual procedure. proposed methodology allows processing MRI axial images, segmenting fuzzy clustering approach. use active contour algorithm on image masks provided...
Abstract A segmental, multislice, multi‐echo T 2 * MRI approach could be useful in heart iron‐overloaded patients to account for heterogeneous iron distribution, demonstrated by histological studies. However, segmental assessment can affected the presence of geometrical and susceptibility artefacts, which act on different segments ways. The aim this study was assess value distribution left ventricle develop a correction procedure compensate artefactual variations analysis. performed four...
Abstract Purpose To describe and evaluate a computer‐assisted method for assessing the quantity distribution of adipose tissue in thigh by magnetic resonance imaging (MRI). Materials Methods Twenty obese subjects were imaged on Philips Achieva 1.5T scanner fast spin‐echo (FSE) sequence. A total 636 images acquired analyzed custom‐made software. Thigh subcutaneous (SAT) bone identified fuzzy clustering segmentation an active contour algorithm. Muscle intermuscular (IMAT) assessed identifying...
T*(2) multislice multiecho cardiac MR allows quantification of the segmental distribution myocardial iron overload. This study aimed to determine if there were preferential patterns overload in thalassemia major. Five hundred twenty-three major patients underwent MR. Three short-axis views left ventricle acquired and analyzed using a 16-segment standardized model. The value on each segment was calculated, as well global value. Four main circumferential regions (anterior, septal, inferior,...
Dissolution‐dynamic nuclear polarization (dissolution‐DNP) for magnetic resonance (MR) spectroscopic imaging has recently emerged as a novel technique noninvasive studies of the metabolic fate biomolecules in vivo . Since acetate is most abundant extra‐ and intracellular short‐chain fatty acid, we focused on [1‐ 13 C]acetate promising candidate chemical probe to study myocardial metabolism beating heart. The dissolution‐DNP procedure Na[1‐ cardiac applications with 3 T MR scanner was...
Hyperpolarization of 13 C‐labeled energy substrates enables the noninvasive detection and mapping metabolic activity, in vivo , with magnetic resonance spectroscopy (MRS). Therefore, hyperpolarization C MRS can potentially become a powerful tool to study physiology organs such as heart, through quantification kinetic patterns under both normal pathological conditions. In this we assessed myocardial uptake metabolism hyperpolarized [1‐ C]pyruvate anesthetized pigs. Pyruvate was studied at...
Background: Low-field Magnetic Resonance Imaging (MRI) (fields below 0.5 T) has received increasing attention since the images produced have been shown to be diagnostically equivalent high-field MR for specific applications, such as musculoskeletal studies. In recent years, low-field MRI made great strides in clinical relevance due advances high-performance gradients, magnet technology, and development of organ-specific radiofrequency (RF) coils, well acquisition sequence design. For...
Survival analysis is a statistical approach widely employed to model the time of an event, such as patient’s death. Classical approaches include Kaplan–Meier estimator and Cox proportional hazards regression, which assume linear relationship between model’s covariates. However, linearity assumption might pose challenges with high-dimensional data, thus stimulating interest in performing survival using neural network models. In present work, we implemented deep (Cox-net) predict cardiac event...
Abstract The present study investigated myocardial T2* heterogeneity in thalassaemia major (TM) patients by cardiac magnetic resonance (CMR), to determine whether is related inhomogeneous iron overload distribution. A total of 230 TM consecutively referred our laboratory were studied retrospectively. Three short‐axis views (basal, medium and apical) the left ventricle (LV) obtained multislice multiecho CMR. segmental distribution was mapped on a 16‐segment LV model. level distribution,...
Radiofrequency (RF) coils for magnetic resonance imaging (MRI) applications serve to generate RF fields excite the nuclei in sample (transmit coil) and pick up signals emitted by (receive coil). For purpose of optimizing image quality, performance has be maximized. In particular, transmit coil provide a homogeneous field, while receive highest signal-to-noise ratio (SNR). Thus, particular attention must paid simulation design phases, which can performed with different computer techniques....
In this paper, we describe a biomimetic-fabric-based sensing glove that can be used to monitor hand posture and gesture. Our device is made of distributed sensor network piezoresistive conductive elastomers integrated into an elastic fabric. This solution does not affect natural movement gestures, worn for long time with no discomfort. The could fruitfully employed in behavioral functional studies MRI (fMRI) during specific tactile or motor tasks. To assess MR compatibility the system,...
Abstract Radiofrequency receiver phased‐array coils in magnetic resonance imaging systems are used to pick up the signals emitted by nuclei with high signal‐to‐noise ratio and a large region of sensitivity. The quality obtained images strongly depends upon correct choice geometry typology. In this work, we propose fast coil simulation method, which permits design great accuracy. developed algorithm exploits magnetostatic analysis obtain accurate calculation mutual inductances between array...