A5101720769- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Sexual function and dysfunction studies
- Urological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Obstructive Sleep Apnea Research
- Surgical Simulation and Training
- Genomics and Chromatin Dynamics
- Urinary Bladder and Prostate Research
- Cancer-related molecular mechanisms research
- Ureteral procedures and complications
- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Bladder and Urothelial Cancer Treatments
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Retinal Diseases and Treatments
- Renal and Vascular Pathologies
Nirma University
2022-2025
Great Western Hospital
2017-2024
Bridge University
2023
University of Cambridge
2016-2023
Cambridge University Hospitals NHS Foundation Trust
2015-2023
Yale University
2023
Yale New Haven Hospital
2023
Addenbrooke's Hospital
2013-2022
Buckinghamshire Healthcare NHS Trust
2022
Cardiff University
2022
BackgroundUnderstanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving way we treat this disease. As yet, there are no validated descriptions subgroups derived from integrated genomics linked with clinical outcome.MethodsIn a study 482 tumour, benign germline samples 259 men primary cancer, used integrative analysis copy number alterations (CNA) array transcriptomics identify genomic loci that affect expression levels mRNA in an quantitative trait...
Abstract Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following vivo exposure to ionizing have not been documented. Here, we searched for 12 radiation-associated second malignancies different tumour types. Two somatic mutation characterize irrespective type. Compared with 319 radiation-naive tumours, tumours carry median extra 201 deletions genome-wide, sized 1–100 base pairs often microhomology at the...
Abstract Hyperpolarised magnetic resonance imaging (HP 13 C-MRI) is an emerging clinical technique to detect [1- C]lactate production in prostate cancer (PCa) following intravenous injection of hyperpolarised C]pyruvate. Here we differentiate clinically significant PCa from indolent disease a low/intermediate-risk population by correlating labelling on MRI with the percentage Gleason pattern 4 (%GP4) disease. Using immunohistochemistry and spatial transcriptomics, show that HP C-MRI...
The androgen receptor (AR) is the dominant growth factor in prostate cancer (PCa). Therefore, understanding how ARs regulate human transcriptome of paramount importance. early effects castration on PCa have not previously been studied 27 patients medically castrated with degarelix 7 d before radical prostatectomy. We used mass spectrometry, immunohistochemistry, and gene expression array (validated by reverse transcription-polymerase chain reaction) to compare resected tumour matched,...
<h3>Introduction</h3> Obstructive sleep apnoea (OSA) is characterised by a loss of neuromuscular tone the upper airway dilator muscles while asleep. This study investigated effectiveness transcutaneous electrical stimulation in patients with OSA. <h3>Patients and methods</h3> was randomised, sham-controlled crossover trial using confirmed Patients were randomly assigned to one night sham active treatment. The primary outcome 4% oxygen desaturation index, responders defined as reduction...
Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does study add? The recent uptake robotic‐assisted laparoscopic radical prostatectomy by urologists has led to questions about its implementation results, particularly with reference learning curve. There have been several large studies, including from USA, but as yet, no published data a series in UK. This is first UK, provides detailed outcomes single centre treating patients an unscreened...
Objectives The aim of this study was to measure the tissue sodium concentration (TSC) within tumors and normal prostate in cancer patients, using prostatectomy as pathological criterion standard. Materials Methods Fifteen patients with biopsy-proven, magnetic resonance imaging (MRI) visible, intermediate- or high-risk underwent a dedicated research MRI, before treatment radical prostatectomy. All participants signed written informed consent for institutional review board–approved prospective...
To assess the added value of 3D T2-weighted imaging (T2WI) over conventional 2D T2WI in diagnosing extracapsular extension (ECE). Seventy-five patients undergoing 3-T MRI before radical prostatectomy were included. PI-RADS ≥ 4 lesions assessed for ECE on T2W images using a 5-point Likert scale (1 = no ECE, 5 definite ECE) and length tumour prostatic capsular contact. A second read reformats evaluated maximal contact surface. One hundred six identified at MRI. was confirmed by histology 54%...
A variety of models have been proposed to explain regions recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) comprehensively assess the role Knudson two hit genetic model SCNA generation prostate 64 loss and gain were detected, which 28 novel, including with more than 15% frequency at Chr4p15.2-p15.1 (15.53%), Chr6q27 (16.50%) Chr18q12.3 (17.48%). Comprehensive mutation screens genes, lincRNA...
Evidence of the accuracy predictive tests in confirming presence and grade upper urinary tract urothelial carcinomas (UUTUC) is limited. We present largest series evaluating diagnostic value pre- intra-operative parameters detection UUTUC.We retrospectively analysed records patients who underwent ureteroscopy between 2005 2014 for suspected UUTUC. Pre-operative workup included voided urine cytology CT imaging. Intra-operative assessments involved to directly visualise suspicious lesions,...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? Despite many descriptions learning curves for open laparoscopic‐assisted prostatectomy, there are few detailed reports describing early phase robotic‐assisted curve. With rapid uptake robotic surgery therefore training, multiple trainees increases complexity analysing an individual surgeon's performance, often leads to omission initial procedures from published case series....
This multicenter, randomized, double-blind, double-dummy, placebo-controlled trial primarily evaluated the efficacy of tadalafil once-daily (OaD) or on-demand ("pro-re-nata"; PRN) treatment, started early post-nsRP. Secondary outcome-measures on quality-of-life (QoL) and treatment satisfaction are reported.Patients, aged <68 yrs, with adenocarcinoma prostate (Gleason ≤ 7, normal preoperative erectile function [EF]) were randomized post-nsRP 1:1:1 to 9-month 5 mg OaD, 20 PRN, placebo,...
The controversies concerning possible overtreatment of prostate cancer, highlighted by debate over PSA screening, have active surveillance (AS) as an alternative management option for appropriate men. Regional differences in the underlying prevalence testing may alter pre-test probability high-risk disease, which can potentially interfere with performance selection criteria AS. In a multicentre study from three different countries, we examine men who were initially suitable AS according to...