A5067195227- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Systems and Public Health
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Ion channel regulation and function
- Ultrasound and Hyperthermia Applications
- Peripheral Artery Disease Management
- Transplantation: Methods and Outcomes
- Ultrasound in Clinical Applications
- Central Venous Catheters and Hemodialysis
Maria Cecilia Hospital
2016-2025
Ospedale Santa Maria
2025
Ospedale Monaldi
2025
Azienda Ospedaliera Bolognini Seriate
2025
Azienda Ospedaliera Universitaria Pisana
2025
Centro Cardiologico Monzino
2024
University of Milan
2024
Azienda Ospedaliera Universitaria Integrata Verona
2023
Fundación Juan March
2023
Thrombosis Research Institute
2022
Background — Forearm endothelial dysfunction, characterized by an impaired vasodilating response to acetylcholine (ACh), may be associated with several cardiovascular risk factors, including essential hypertension. Although the prognostic value of coronary dysfunction has been demonstrated, that forearm is still unknown. Methods and Results Endothelium-dependent -independent vasodilation was investigated in 225 never-treated hypertensive patients (age, 35 54 years) intra-arterial infusion...
BackgroundEarly results of the Micra Investigational Device Exemption (IDE) study and Post-Approval Registry (PAR) demonstrated excellent safety efficacy performance; however, intermediate-term across a large patient population in real-world setting have not been evaluated.ObjectivesWe report updated performance transcatheter pacemaker from worldwide PAR compare it with IDE as well transvenous historical control.MethodsThe objective analysis was system- or procedure-related major...
BackgroundFirst-in-man studies of leadless pacemakers have demonstrated high rates implant success, and safety efficacy objectives were achieved. Outside the investigational setting, there are concerns, particularly over cardiac effusion perforation, device dislodgement, infection, telemetry, battery issues.ObjectiveThe acute performance Micra transcatheter pacemaker from a worldwide Post-Approval Registry is reported.MethodsThe registry an ongoing prospective single-arm observational study...
On the basis of current knowledge, cardiac resynchronization therapy (CRT) cannot be recommended as a first-line treatment for patients with severely symptomatic permanent atrial fibrillation undergoing atrioventricular (AV) junction ablation. We examined whether CRT was superior to conventional right ventricular (RV) pacing in reducing heart failure (HF) events.In this prospective, multi-centre study, we randomly assigned 186 patients, whom AV ablation and device implantation had been...
Abstract Aims Treatment guidelines for patients with atrial fibrillation (AF) suggest that should be managed an antiarrhythmic drug (AAD) before undergoing catheter ablation (CA). This study evaluated whether pulmonary vein isolation employing cryoballoon CA is superior to AAD therapy the prevention of arrhythmia (AA) recurrence in rhythm control naive paroxysmal AF (PAF). Methods and results A total 218 treatment symptomatic PAF were randomized (1 : 1) (Arctic Front Advance, Medtronic) or...
Abstract Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), which pre-clinical and early-stage clinical data are suggestive some degree preferentiality to myocardial tissue without damage adjacent structures. Here in MANIFEST-17K study we assessed safety PFA by studying post-approval use this modality. Of 116 centers performing with a pentaspline catheter, were received from 106 (91.4% participation) regarding 17,642 patients undergoing (mean...
Abstract Background and Aims Prior reports have demonstrated a favourable safety efficacy profile of the Micra leadless pacemaker over mid-term follow-up; however, long-term outcomes in real-world clinical practice remain unknown. Updated performance VR through five years from worldwide post-approval registry (PAR) was assessed. Methods All PAR patients undergoing implant attempts were included. Endpoints included system- or procedure-related major complications system revision rate for any...
Limited data exist on pulsed-field ablation (PFA) in patients with persistent atrial fibrillation (PeAF) undergoing left posterior wall isolation (LAPWI).
Endothelial dysfunction has been reported in obese subjects, but its mechanism not elucidated. We have therefore investigated 1) the possible relationship among BMI, waist-to-hip ratio (WHR), and endothelium-dependent vasodilation 2) whether oxidative stress participates endothelial dysfunction. recruited 76 healthy subjects (50 men 26 women aged 21-45 years) measured their BMI (kg/m2), WHR, insulin resistance (IR) estimated by homeostasis model assessment (HOMA). Endothelium-dependent...
Background: Remote monitoring (RM) in patients with advanced heart failure and cardiac resynchronization therapy defibrillators (CRT-D) may reduce delays clinical decisions by transmitting automatic alerts. However, this strategy has never been tested specifically patient population, alerts for lung fluid overload, a European setting. Objective: The main objective of Phase 1 (presented here) is to evaluate if RM able time from device-detected events decisions. Methods: In multicenter...
Abstract Introduction Cryoablation therapy for pulmonary vein isolation (PVI) to treat paroxysmal atrial fibrillation (PAF) is well established. A novel 28 mm cryoballoon system designed operate under low pressure safely reach a lower nadir temperature and maintain constant balloon size during cooling has not been prospectively studied in large patient population safety efficacy. The FROZEN AF (NCT04133168) trial was an international multicenter, open‐label, prospective, single‐arm study on...
Purpose: Some implantable cardioverter‐defibrillators (ICDs) are now able to monitor intrathoracic impedance. The aim of the study was describe use such monitoring in clinical practice and evaluate impact fluid accumulation alert feature these ICDs. Methods Results: Five hundred thirty‐two heart failure (HF) patients implanted with ICDs were followed up for 11 ± 7 months. A event (CE) deemed have occurred if it resulted hospitalization or milder manifestations HF deterioration. Three...
Background— Long-term data on device-related untoward events in patients receiving defibrillators for resynchronization therapy (CRT-D) are lacking. We quantified the frequency of repeat invasive procedures and nature long-term complications current clinical practice examined possible predictors their association with patient outcome. Methods Results— analyzed from 3253 who underwent de novo successful implantation CRT-D were followed up a median 18 months (25th to 75th percentiles: 9 30)...
Pulmonary vein isolation (PVI) is well established as a primary treatment for atrial fibrillation (AF). The POLAR ICE study was designed to collect prospective real world data on the safety and effectiveness of POLARxTM cryoballoon PVI treat paroxysmal AF.POLAR ICE, prospective, non-randomized, multicenter (international) registry (NCT04250714), enrolled 399 patients across 19 European centers. Procedural characteristics, such time isolation, cryoablations per pulmonary (PV), balloon nadir...
Abstract Aims The safety and efficacy of leadless intracardiac-permanent pacemaker (L-PM) have been demonstrated in multiple clinical trials, but data on comparisons with conventional transvenous-permanent (T-PM) collected a consecutive, prospective fashion are limited. aim this analysis was to compare the rate nature device-related complications between patients undergoing L-PM vs. T-PM implantation. Methods results Prospective, multicentre, observational project enrolling consecutive who...
The incidence of infections associated with cardiac implantable electronic devices (CIEDs) and patient outcomes are not fully known.
Abstract The second generation of transcatheter pacing systems, called Micra AV, can provide atrioventricular (AV) synchronous via a new algorithm relying on sensing mechanical atrial contraction. Several novel programming parameters were introduced to enable AV pacing, including an A3 window and A4 as well conduction mode switch activity switch. In addition several automated features, manual optimization some the is key improving synchrony. A solid knowledge features their essential for...