A5080659974- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Nerve injury and regeneration
- Sleep and related disorders
- Restless Legs Syndrome Research
- Nutrition and Health in Aging
- Patient-Provider Communication in Healthcare
- Sleep and Wakefulness Research
- Pluripotent Stem Cells Research
- Health disparities and outcomes
- Autism Spectrum Disorder Research
- Botulinum Toxin and Related Neurological Disorders
- Global Cancer Incidence and Screening
- Youth Substance Use and School Attendance
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health, psychology, and well-being
- Dementia and Cognitive Impairment Research
- Family Support in Illness
- Nuclear Receptors and Signaling
- BRCA gene mutations in cancer
- Multiple Sclerosis Research Studies
- Clinical Nutrition and Gastroenterology
Lund University
2010-2025
Kristianstad University
2016-2025
Patient-Centered Outcomes Research Institute
2013-2020
Karlstad University
2020
Department of Medical Sciences
2004-2014
Early Manuscripts Electronic Library
2014
Family Carers Ireland
2002-2013
Skåne University Hospital
2011-2013
In-Q-Tel
2013
St. Joseph's Hospital and Medical Center
2009
Abstract Six patients with Parkinson's disease were followed for 10 to 72 months after human embryonic mesencephalic tissue from four seven donors was grafted unilaterally into the putamen (4 patients) or plus caudate (2 patients). After 8 12 months, positron emission tomography showed a 68% increase of 6‐ L −[ 18 F]‐fluorodopa uptake in putamen, no change caudate, and minor decreases nongrafted striatal regions. There therapeutically valuable improvement 4 patients, but only modest changes...
Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven nine donors. To increase graft survival, lipid peroxidation inhibitor tirilazad mesylate was administered to before implantation intravenously for 3 days thereafter. During second postoperative year, mean daily L-dopa dose reduced by 54% UPDRS (Unified Parkinson's Disease Rating Scale) motor score in `off' phase a of 40%. At 10–23 months...
Five parkinsonian patients who had received implants of human embryonic mesencephalic tissue unilaterally in the striatum 10–56 months earlier were grafted with from four to eight donors into putamen (four patients) or plus caudate nucleus (one patient) on other side, and followed for 18–24 months. After 12–18 months, PET showed a mean 85% increase 6-L-[18F]fluorodopa uptake second graft, whereas there was no significant further change previously transplanted putamen. Two exhibited marked...
Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss nigrostriatal projections and consequent dysfunction striatocortical circuitries in Parkinson's disease (PD). Here, we have studied effects bilateral human embryonic grafts on movement-related activation frontal cortical areas 4 PD patients using H215O positron emission tomography a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by...
Intrastriatal grafts of embryonic mesencephalic tissue can survive in the brains patients with Parkinson's disease, but degree symptomatic relief is highly variable and some cases develop troublesome dyskinesias. Here we explored, using clinical assessment 18F-dopa 11C-raclopride PET, factors which may influence functional outcome after transplantation. We observed increased uptake grafted putamen, signifying continued survival transplanted dopaminergic neurons, parallel a progressive...
<h3>OBJECTIVES</h3> Despite the recent introduction of new peroral drugs as well neurosurgical methods for Parkinson's disease, treatment late stage parkinsonian patients remains difficult and many become severely handicapped because fluctuations in their motor status. Injections infusions apomorphine has been suggested an alternative these patients, but number studies describing effects such a over longer time periods is still limited. The objective was to investigate therapeutic response...
<h3>Background:</h3> The 39 item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in disease. However, several fundamental measurement assumptions necessary for confident use and interpretation of eight PDQ-39 scales have not been fully addressed. <h3>Methods:</h3> Postal survey data from 202 people with (54% men; mean age 70 years) were analysed regarding psychometric properties using traditional Rasch methods. <h3>Results:</h3> Data quality...
To gain an improved understanding of fatigue in Parkinson disease (PD) by exploring possible predictors among a wide range motor and non-motor aspects PD.118 consecutive PD patients (54% men; mean age 64 years) were assessed regarding fatigue, demographics symptoms. Variables significantly associated with scores bivariate analyses used multiple regression as the dependent variable.Fatigue was increasing Hoehn & Yahr stages, specifically transition from stages I-II to III-V. Regression...
This study aimed to comprehensibly investigate potential contributing factors fear of falling (FOF) among people with idiopathic Parkinson’s disease (PD). The included 104 PD. Mean (SD) age and PD-duration were 68 (9.4) 5 (4.2) years, respectively, the participants’ PD-symptoms relatively mild. FOF (the dependent variable) was investigated Swedish version Falls Efficacy Scale, i.e. FES(S). first multiple linear regression model replicated a previous independent variables targeted: walking...
Psychometric theory requires unidimensionality (i.e., scale items should represent a common latent variable). One advocated approach to test within the Rasch model is identify two item sets from Principal Component Analysis (PCA) of residuals, estimate separate person measures based on sets, compare estimates person-by-person basis using t-tests and determine number cases that differ significantly at 0.05-level; if ≤5% tests are significant, or lower bound binomial 95% confidence interval...
Background: Mastery refers to the degree which people perceive that they can control factors influence their life situation, and has been found important for people's quality of well-being. It is thus essential be able measure mastery in a valid reliable way. Aim: This study aimed at using Rasch measurement model investigate psychometric properties Swedish version Pearlin Scale (Mastery-S). Methods: A sample 300 healthy individuals 278 persons with mental illness responded Mastery-S. Item...
Background: Occupational balance is fundamental to occupational therapy and science. Therefore, the Balance Questionnaire (OBQ) was developed has previously been found psychometrically valid according classical test theory.Aim: To investigate internal construct validity of OBQ using Rasch measurement theory.Material methods: Data from two general population samples were used psychometric properties theory.Results: The analyses identified problems with current response scale...
Objective To determine factors associated with future falls and/or near in people mild PD. Methods The study included 141 participants Mean (SD) age and PD-duration were 68 (9.7) 4 years (3.9), respectively. Their median (q1–q3) UPDRS III score was 13 (8-18). Those >80 of age, requiring support standing or unable to understand instructions excluded. Self-administered questionnaires targeted freezing gait, turning hesitations, walking difficulties daily life, fatigue, fear falling,...