A5060721549- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Atomic and Subatomic Physics Research
- Fetal and Pediatric Neurological Disorders
- Medical Imaging Techniques and Applications
- Ion channel regulation and function
- Blind Source Separation Techniques
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- Memory and Neural Mechanisms
- Electrochemical Analysis and Applications
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
University of Geneva
2016-2025
University Hospital of Geneva
2016-2025
Centre d'Imagerie BioMedicale
2021-2025
University College London
2009-2024
National Hospital for Neurology and Neurosurgery
2009-2024
University Hospital of Lausanne
2002-2024
Hôpital Beau-Séjour
2006-2023
Stockholm Health Care Services
2021
Karolinska Institutet
2021
Ospedale Policlinico San Martino
2021
Electroencephalography is mandatory to determine the epilepsy syndrome. However, for precise localization of irritative zone in patients with focal epilepsy, costly and sometimes cumbersome imaging techniques are used. Recent small studies using electric source suggest that electroencephalography itself could be used localize focus. a large prospective validation study missing. This presents cohort 152 operated where was applied as part pre-surgical work-up allowing comparison results from...
In patients with medically refractory focal epilepsy who are candidates for surgery, concordant non-invasive neuroimaging data useful to guide invasive electroencephalographic recordings or surgical resection. Simultaneous electroencephalography and functional magnetic resonance imaging can reveal regions of haemodynamic fluctuations related epileptic activity help localize its generators. However, many these studies (40–70%) remain inconclusive, principally due the absence interictal...
<h3>Objective</h3> It remains controversial whether interictal spikes are a surrogate of the seizure onset zone (SOZ). Electric source imaging (ESI) is an increasingly validated non-invasive approach for localising epileptogenic focus in patients with drug-resistant epilepsy undergoing evaluation surgery, using high-density scalp EEG and advanced localisation algorithms that include patient9s own MRI. Here we investigate by ESI provides valuable information on SOZ. <h3>Methods</h3> In 38...
<h3>Objective</h3> Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. <h3>Methods</h3> Sixteen European centers retrospectively identified cohorts of children adults who underwent epilepsy the period 1997 to 1998 (n = 562) or 2012 2013 736). Data collected included patient (sex, age) disease (duration, localization...
Summary Objective There is increasing evidence that epileptic activity involves widespread brain networks rather than single sources and these contribute to interictal dysfunction. We investigated the fast‐varying behavior of during spikes in right left temporal lobe epilepsy ( RTLE LTLE ) at a whole‐brain scale using directed connectivity. Methods In 16 patients, 8 with , we estimated electrical source 82 cortical regions interest ROIs high‐density electroencephalography EEG) individual...
Surgical treatment of focal epilepsy in patients with cortical dysplasia (FCD) is most successful if all epileptogenic tissue resected. This may not be evident on structural magnetic resonance imaging (MRI), so intracranial electroencephalography (icEEG) needed to delineate the seizure onset zone (SOZ). EEG-functional MRI (fMRI) can reveal interictal discharge (IED)-related hemodynamic changes irritative (IZ). We assessed value EEG-fMRI FCD-associated by examining relationship between...
Summary Objective In patients with epilepsy, seizure relapse and behavioral impairments can be observed despite the absence of interictal epileptiform discharges ( IED s). Therefore, characterization pathologic networks when IEDs are not present could have an important clinical value. Using Granger‐causal modeling, we investigated whether directed functional connectivity was altered in electroencephalography EEG ) epochs free left right temporal lobe epilepsy LTLE RTLE compared to healthy...
Electrical source imaging (ESI) aims at reconstructing the electrical brain activity from scalp EEG. When applied to interictal epileptiform discharges (IEDs), this technique is of great use for identifying irritative zone in focal epilepsies. Inaccuracies modeling electro-magnetic field propagation head (forward model) may strongly influence ESI and lead mislocalization IED generators. However, a systematic study on selected model localization precision large number patients with known...
Summary Objective In 2014 the European Union–funded E‐ PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed investigate current use of neuroimaging, electromagnetic source localization, imaging postprocessing procedures in participating centers. Methods A survey on clinical imaging, methods candidates distributed among 25 centers consortium. descriptive analysis performed, results were compared existing guidelines...
Summary Objective Electrical source imaging ( ESI ) is a well‐established approach to localizing the epileptic focus in drug‐resistant focal epilepsy. So far, has been used primarily on interictal events. Emerging evidence suggests that ictal also feasible and potentially useful. We aimed investigate diagnostic accuracy of events using high‐density electroencephalography (EEG). Methods performed 14 patients (9 with temporal lobe epilepsy) admitted for presurgical evaluation who presented...
Abstract Objective This study was undertaken to develop a standardized grading system based on expert consensus for evaluating the level of confidence in localization epileptogenic zone (EZ) as reported published studies, harmonize and facilitate systematic reviews field epilepsy surgery. Methods We conducted Delphi involving 22 experts from 18 countries, who were asked rate their EZ various theoretical clinical scenarios, using different scales. Information provided these scenarios included...
Abstract Aortic compliance and pulse wave velocity (PWV) are important determiners of heart load, clinically useful indices cardiovascular risk. Most direct methods to derive them require invasive pressure measurement. In this work a noninvasive technique evaluate aortic PWV using MRI is proposed. magnitude phase images measure area flow in the ascending aorta were acquired group 13 young healthy subjects. Assuming that early systolic part was unidirectional reflectionless, determined as...
Simultaneous EEG–fMRI acquisitions in patients with epilepsy often reveal distributed patterns of Blood Oxygen Level Dependant (BOLD) change correlated epileptiform discharges. We investigated if electrical source imaging (ESI) performed on the interictal discharges (IED) acquired during fMRI acquisition could be used to study dynamics networks identified by BOLD effect, thereby avoiding limitations combining results from separate recordings. Nine selected (13 IED types identified) focal...
We tested the performance and clinical applicability of combined protocols for brain imaging studies acquired on a new whole-body hybrid PET/MR scanner.Fifteen patients [6 male 9 female patients; mean (SD) age, 51 (30) y; range, 6-89 y] were scanned Philips Ingenuity TF PET/MR. Standard both modalities combined, using "head coil" contrast-enhanced fully diagnostic MR protocols. Attenuation correction PET images was performed tissue segmentation image incorporation attenuation templates...
Purpose: Subtle structural abnormalities of frontal lobe gray and white matter have been described in cryptogenic idiopathic generalized epilepsies. The supplementary motor area (SMA) has a role control, its involvement during epileptic seizures is characterized by typical asymmetric tonic posturing. Moreover, networks are dysfunctional juvenile myoclonic epilepsy (JME). We tested the hypothesis that SMA connectivity altered focal (FLE) JME compared to healthy controls. Methods: Diffusion...
Drug-resistant temporal lobe epilepsy (TLE) often requires thorough investigation to define the epileptogenic zone for surgical treatment. We used simultaneous interictal scalp EEG-fMRI evaluate its value predicting long-term postsurgical outcome.30 patients undergoing presurgical evaluation and proceeding (TL) resection were studied. Interictal epileptiform discharges (IEDs) identified on intra-MRI EEG build a model of haemodynamic changes. In addition, topographic electroencephalographic...