A5053828831- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Visual perception and processing mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Face Recognition and Perception
- Metabolism and Genetic Disorders
- Neural and Behavioral Psychology Studies
- Atomic and Subatomic Physics Research
- Memory and Neural Mechanisms
- Psychosomatic Disorders and Their Treatments
- Diet and metabolism studies
- Fetal and Pediatric Neurological Disorders
- Medical Imaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Blind Source Separation Techniques
- Sleep and Wakefulness Research
- Neurology and Historical Studies
- Multisensory perception and integration
University of Geneva
2016-2025
University Hospital of Geneva
2016-2025
Hôpital Beau-Séjour
2013-2024
University Hospital of Lausanne
2006-2024
Medical University of Vienna
2023
Hôpital Pasteur
2023
Swiss Epilepsy Center
2004-2022
Geneva College
1997-2022
University of Göttingen
2022
Universitätsmedizin Göttingen
2022
During an out-of-body experience (OBE), the experient seems to be awake and see his body world from a location outside physical body. A closely related is autoscopy (AS), which characterized by of seeing one's in extrapersonal space. Yet, despite great public interest many case studies, systematic neurological studies OBE AS are extremely rare and, date, no testable neuroscientific theory exists. The present study describes phenomenological, neuropsychological neuroimaging correlates six...
The spatial unity of self and body is challenged by various philosophical considerations several phenomena, perhaps most notoriously the “out-of-body experience” (OBE) during which one's visual perspective are experienced to have departed from their habitual position within body. Although researchers started examining isolated aspects self, neurocognitive processes OBEs not been investigated experimentally further our understanding self. With use evoked potential mapping, we show selective...
Electroencephalography is mandatory to determine the epilepsy syndrome. However, for precise localization of irritative zone in patients with focal epilepsy, costly and sometimes cumbersome imaging techniques are used. Recent small studies using electric source suggest that electroencephalography itself could be used localize focus. a large prospective validation study missing. This presents cohort 152 operated where was applied as part pre-surgical work-up allowing comparison results from...
In patients with medically refractory focal epilepsy who are candidates for surgery, concordant non-invasive neuroimaging data useful to guide invasive electroencephalographic recordings or surgical resection. Simultaneous electroencephalography and functional magnetic resonance imaging can reveal regions of haemodynamic fluctuations related epileptic activity help localize its generators. However, many these studies (40–70%) remain inconclusive, principally due the absence interictal...
The authors evaluated the feasibility, clinical yield, and localization precision of high-resolution EEG source imaging interictal epileptic activity. A consecutive series 44 patients with intractable epilepsy various causes, who underwent a comprehensive presurgical evaluation, were subjected to 128-channel recording. standardized procedure constrained individual gray matter was applied averaged spikes each patient. In 32 patients, workup identified focal epileptogenic area. correctly...
Recent research has shown that heartbeat-evoked potentials (HEPs), brain activity in response to heartbeats, are a useful neural measure for investigating the functional role of brain–body interactions cognitive processes including self-consciousness. In 2 experiments, using intracranial electroencephalography (EEG), we investigated (1) sources HEPs, (2) underlying mechanisms HEP generation, and (3) HEPs bodily Experiment-1, found shortly after heartbeat onset, phase distributions across...
Summary Objective The discovery of mutations in DEPDC 5 familial focal epilepsies has introduced a novel pathomechanism to field so far dominated by ion channelopathies. is part complex named GAP activity toward RAGs (GATOR) 1 ( GATOR 1), together with the proteins NPRL 2 and 3, acts inhibit mechanistic target rapamycin mTOR ) mTORC 1) pathway. turn inhibited complex. pathway major signaling cascade regulating cell growth, proliferation, migration. We aimed study contribution genes etiology...
<h3>Objective</h3> Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. <h3>Methods</h3> Sixteen European centers retrospectively identified cohorts of children adults who underwent epilepsy the period 1997 to 1998 (n = 562) or 2012 2013 736). Data collected included patient (sex, age) disease (duration, localization...
Summary Objective There is increasing evidence that epileptic activity involves widespread brain networks rather than single sources and these contribute to interictal dysfunction. We investigated the fast‐varying behavior of during spikes in right left temporal lobe epilepsy ( RTLE LTLE ) at a whole‐brain scale using directed connectivity. Methods In 16 patients, 8 with , we estimated electrical source 82 cortical regions interest ROIs high‐density electroencephalography EEG) individual...
Summary Objective In patients with epilepsy, seizure relapse and behavioral impairments can be observed despite the absence of interictal epileptiform discharges ( IED s). Therefore, characterization pathologic networks when IEDs are not present could have an important clinical value. Using Granger‐causal modeling, we investigated whether directed functional connectivity was altered in electroencephalography EEG ) epochs free left right temporal lobe epilepsy LTLE RTLE compared to healthy...
The definition of minimal standards remains pivotal as a basis for high standard care and staff allocation or reimbursement. Only limited publications are available regarding the required staffing methodologic expertise in epilepsy centers. executive board working group (WG) on presurgical diagnosis operative treatment published first guidelines 2000 Austria, Germany, Switzerland. In 2014, revised were WG decided to publish an unaltered English translation this report. Because surgery is...
Electrical source imaging (ESI) aims at reconstructing the electrical brain activity from scalp EEG. When applied to interictal epileptiform discharges (IEDs), this technique is of great use for identifying irritative zone in focal epilepsies. Inaccuracies modeling electro-magnetic field propagation head (forward model) may strongly influence ESI and lead mislocalization IED generators. However, a systematic study on selected model localization precision large number patients with known...
Spontaneous fluctuations of neuronal activity in large-scale distributed networks are a hallmark the resting brain. In relapsing-remitting multiple sclerosis (RRMS) several fMRI studies have suggested altered resting-state connectivity patterns. Topographical EEG analysis reveals much faster temporal tens milliseconds time range (termed "microstates"), which showed properties number neuropsychiatric conditions. We investigated whether these microstates were patients with RRMS, and if...