A5027477006- Multiple Sclerosis Research Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Vestibular and auditory disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Attention Deficit Hyperactivity Disorder
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Nonlinear Dynamics and Pattern Formation
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience and Neural Engineering
- Electrochemical Analysis and Applications
- Systemic Lupus Erythematosus Research
- Amyotrophic Lateral Sclerosis Research
- Rheumatoid Arthritis Research and Therapies
- stochastic dynamics and bifurcation
- Neuroscience and Neuropharmacology Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Transcranial Magnetic Stimulation Studies
- Psychedelics and Drug Studies
- Osteomyelitis and Bone Disorders Research
University Hospital of Basel
2014-2024
University of Basel
2008-2024
Swiss National Science Foundation
2020
Multiple Sclerosis Society
2020
Roche (Switzerland)
2019-2020
University of California, Irvine
2019
Université de Sherbrooke
2019
Douglas Mental Health University Institute
2019
Helios Kliniken
2019
McGill University
2019
Functional connectivity (FC) and graph measures provide powerful means to analyze complex networks. The current study determines the inter-subject-variability using coefficient of variation (CoV) long-term test-retest-reliability (TRT) intra-class correlation (ICC) in 44 healthy subjects with 35 having a follow-up at years 1 2. FC was estimated from 256-channel-EEG by phase-lag-index (PLI) weighted PLI (wPLI) during an eyes-closed resting state condition. quantifies asymmetry distribution...
While many insights on brain development and aging have been gained by studying resting-state networks with fMRI, relating these changes to cognitive functions is limited the temporal resolution of fMRI. In order better grasp short-lasting dynamically changing mental activities, an increasing number studies utilize EEG define networks, thereby often using concept microstates. These are brief (around 100 ms) periods stable scalp potential fields that influenced states sensitive...
Spontaneous fluctuations of neuronal activity in large-scale distributed networks are a hallmark the resting brain. In relapsing-remitting multiple sclerosis (RRMS) several fMRI studies have suggested altered resting-state connectivity patterns. Topographical EEG analysis reveals much faster temporal tens milliseconds time range (termed "microstates"), which showed properties number neuropsychiatric conditions. We investigated whether these microstates were patients with RRMS, and if...
Background: Slowing of the electroencephalogram (EEG) is frequent in Parkinson's (PD) and Alzheimer's Disease (AD) correlates with cognitive decline. As overlap pathology plays a role pathogenesis dementia, it likely that demented patients PD show similar physiological alterations as AD. Objective: To analyze distinctive quantitative EEG characteristics early dysfunction Methods: Forty (20 PD- 20 AD impairment) normal controls (NC) were matched for gender, age education. Resting state was...
<b>Objective:</b> To determine the time course of brain atrophy during treatment with once-weekly IM interferon β-1a (IFNβ-1a). <b>Methods:</b> The MRI cohort (n = 386) European IFNβ-1a dose comparison study in relapsing multiple sclerosis (MS) was analyzed. In addition to baseline and three annual scans, a frequent subgroup 138) had two scans before initiation at months 4, 5, 6, 10, 11. Brain parenchymal fraction (BPF), normalized measure whole-brain atrophy, volume Gd-enhancing lesions...
Background Cognitive dysfunction in multiple sclerosis (MS) is frequent. Insight into underlying mechanisms would help to develop therapeutic strategies. Objective To explore the relationship of cognitive performance patterns nodal centrality derived from magneto-encephalography (MEG). Methods 34 early relapsing-remitting MS patients (median EDSS 2.0) and 28 age- gender-matched healthy controls (HC) had a MEG, neuropsychological assessment structural MRI. Resting-state functional...
Abstract Introduction Electroencephalography (EEG) microstates and brain network are altered in patients with Alzheimer’s disease (AD) discussed as potential biomarkers for AD. Microstates correspond to defined states of activity, their connectivity patterns may change accordingly. Little is known about alteration microstates, especially amnestic mild cognitive impairment stable or improving cognition within 30 months (aMCI). Methods Thirty-five outpatients aMCI dementia (mean age 77 ± 7...
To study if the thalamic lateral geniculate nucleus (LGN) is affected in multiple sclerosis (MS) due to anterograde degeneration from optic neuritis (ON) or retrograde radiation (OR) pathology, and this relevant for visual function.In cross-sectional study, LGN volume of 34 patients with relapsing-remitting MS 33 matched healthy controls (HC) was assessed on MRI using atlas-based automated segmentation (MAGeT). ON history, thickness ganglion cell-inner plexiform layer (GC-IPL), OR lesion...
To compare the ability of different evoked potential scores (EPS) to monitor and predict disease course in multiple sclerosis (MS).Seventy-two patients with MS or clinically isolated syndrome were investigated by visual, motor, somatosensory EP expanded disability status scale (EDSS) at baseline (T0) months 6, 12, 24, 36 (T4). results rated according ordinal (o), semi-quantitative (sq), quantitative (q) EPS. Spearman rank correlation multivariable linear regression used investigate...
The pharmacokinetics and pharmacodynamics of a highly concentrated cyclodextrin-based intranasal (i.n.) midazolam formulation containing the absorption-enhancer chitosan were studied in 12 healthy volunteers compared with intravenous (i.v.) midazolam. pharmacodynamic (PD) effects assessed using quantitative electroencephalography (EEG). Maximal plasma concentrations 63 110 ng/ml reached at 8.4 7.6 min after 3 6 mg i.n. midazolam, respectively. After 5 i.v. times to onset significant EEG β2...
<b><i>Background:</i></b> Cognitive deficits in Parkinson's disease (PD) are heterogeneous and can be classified into cognitive domains. Quantitative EEG is related to predictive of status PD. In this cross-sectional study, the relationship domains slowing PD patients without dementia investigated. <b><i>Methods:</i></b> A total 48 with idiopathic were neuropsychologically tested. domain scores calculated combining Z-scores test variables....
Mild cognitive impairment in Parkinson's disease (PD-MCI) is diagnosed based on the results of a standardized set tests. We investigate whether quantitative EEG (qEEG) measures could identify differences between cognitively normal PD (PD-CogNL) and PD-MCI patients. High-resolution was recorded 53 patients with (PD). Relative power five frequency bands calculated globally for ten regions. Peak median frequencies were determined. qEEG compared groups. Effect sizes all variables calculated. The...
Objectives: To explore long-term effects of treatment and prognostic relevance variables assessed at baseline during the European secondary progressive multiple sclerosis (SPMS) trial interferon beta 1b (IFNB-1b). Methods: We 362 patients (60% female; median age 41 years; Expanded Disability Status Scale (EDSS): 5.5; 51% randomized to IFNB-1b) for their EDSS history after 10 years. Non-parametric analysis covariance (ANCOVA) multivariate linear regression models were applied. Results: Median...
Atrophy is recognized as a measure of destructive changes in multiple sclerosis (MS). The time course and pathologic mechanisms atrophy development are not well understood. Significant was reported to occur within 9 12 months relapsing remitting MS.To test whether can be detected over short intervals, evaluate its relationship inflammation.Prior randomization treatment trial, 138 untreated patients with MS had 3 magnetic resonance imaging scans mean +/- SD follow-up 76 20.2 days. Brain...
Connectivity analysis characterizes normal and altered brain function, for example, using the phase lag index (PLI), which is based on relations. However, reliability of PLI over time limited, especially single- or regional-link analysis. One possible cause repeated changes network configuration during registration. These may be associated with surface potential fields, can characterized by microstate Microstate describes repeating periods quasistable fields lasting in subsecond range. This...
Motor and sensory evoked potentials (EP) are potential candidate biomarkers for clinical trials in multiple sclerosis.To determine test -retest reliability of motor EP (MEP) (SEP) associated EP-scores patients with sclerosis.In three centres, 16 relapsing five progressive sclerosis had MEPs SEPs 1-29 days apart. Five neurophysiologists independently marked latencies by central reading. By variance component analysis, we estimated the critical difference (absolute reliability) cross-sectional...
To explore associations of the main component (P100) visual evoked potentials (VEP) to pre- and postchiasmatic damage in multiple sclerosis (MS). 31 patients (median EDSS: 2.5), 13 with previous optic neuritis (ON), healthy controls had VEP, optical coherence tomography magnetic resonance imaging. We tested P100-latency peripapillary retinal nerve fiber layer (pRNFL), ganglion cell/inner plexiform layers (GCIPL), lateral geniculate nucleus volume (LGN), white matter lesions radiations...