A5037377084- Health Systems, Economic Evaluations, Quality of Life
- Health Sciences Research and Education
- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Statistical Methods in Clinical Trials
- Meta-analysis and systematic reviews
- Innovations in Medical Education
- Antibiotics Pharmacokinetics and Efficacy
- Nursing Diagnosis and Documentation
- Health Policy Implementation Science
- Health and Medical Research Impacts
- Drug Transport and Resistance Mechanisms
- Education Methods and Technologies
- Sinusitis and nasal conditions
- Genomics, phytochemicals, and oxidative stress
- Antibiotic Use and Resistance
- Bipolar Disorder and Treatment
- Urinary Tract Infections Management
- Retinal and Macular Surgery
- Pharmacy and Medical Practices
- Cancer therapeutics and mechanisms
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Medication Adherence and Compliance
- Patient Satisfaction in Healthcare
University Hospital of Basel
2008-2025
University of Basel
2007-2025
University Hospital of Zurich
2012
Amsterdam University Medical Centers
2012
Universitäre Psychiatrische Dienste Bern
2012
Institute of Molecular and Clinical Ophthalmology Basel
2011
Roche (Switzerland)
1987-1989
Fleroxacin (Ro 23-6240; AM-833) is a new trifluorinated quinolone exhibiting high activity against broad spectrum of gram-negative and gram-positive bacteria. Healthy male volunteers received, according to randomized scheme, oral doses 200, 400, or 800 mg fleroxacin in tablet form, an intravenous infusion 100 mg, 400 orally together with 1,000 probenecid. characterized pharmacokinetically by long elimination half-life (9 10 h) concentrations plasma (e.g., maximum concentration 2.3...
Introduction: Evidence-based medicine (EBM) improves the quality of health care. Courses on how to teach EBM in practice are available, but knowledge does not automatically imply its application teaching. We aimed identify and compare barriers facilitators for teaching clinical various European countries.Methods: A questionnaire was constructed listing potential practice. Answers were reported a 7-point Likert scale ranging from at all being barrier an insurmountable barrier.Results: The...
To investigate the pharmacokinetics and pharmacodynamics of nasal formulations containing midazolam (5-30 mg ml(-1)) complexed with cyclodextrin.An open-label sequential trial was conducted in eight healthy subjects receiving single doses 1 3 intranasally intravenously. Pharmacokinetic parameters were obtained by non-compartmental two-compartmental models. Pharmacodynamic effects assessed using VAS a reaction time test.Mean bioavailability after administration ranged from 76 +/- 12% to 92...
The pharmacokinetics and pharmacodynamics of a highly concentrated cyclodextrin-based intranasal (i.n.) midazolam formulation containing the absorption-enhancer chitosan were studied in 12 healthy volunteers compared with intravenous (i.v.) midazolam. pharmacodynamic (PD) effects assessed using quantitative electroencephalography (EEG). Maximal plasma concentrations 63 110 ng/ml reached at 8.4 7.6 min after 3 6 mg i.n. midazolam, respectively. After 5 i.v. times to onset significant EEG β2...
Alleles of the human leukocyte antigen (HLA) system have been associated with occurrence idiosyncratic adverse drug reactions (ADRs). Accordingly, it is assumed that pre-emptive testing for presence certain HLA alleles (HLA-typing) could prevent these ADRs in carriers. In order to perceive current evidence HLA-associated ADRs, we conducted a scoping review according Preferred Reporting Items Systematic Reviews and Meta-Analyses (PRISMA). The literature search on PubMed Embase was carried out...
Implementation of pharmacogenetics (PGx) and individualization drug therapy is supposed to obviate adverse reactions or failure. Health care professionals (HCPs) use labels (DLs) as reliable information about drugs. We analyzed the Swiss DLs give an overview on currently available PGx instructions. screened 4306 applying natural language processing focusing metabolism (pharmacokinetics) we assigned levels following classification system PharmGKB. From 5979 hits, 2564 were classified...
Importance Improving methodological quality is a priority in the health research community. Finding appropriate methods guidance can be challenging due to heterogeneous terminology, poor indexing medical databases, and variation formats. The Library of Guidance for Health Scientists (LIGHTS) new searchable database articles. Observations Journal articles that aim provide performing (including planning, design, conduct, analysis, interpretation), reporting, assessing health-related involving...
Abstract Background Over the past decade, evidence‐based medicine (EBM) has gained recognition as a means to improve quality of health care provision. However, little is known about learning opportunities acquire EBM‐associated skills. The EUebm‐Unity partnership explored current educational activities for EBM practice doctors across Europe. Methods We surveyed organizations offering postgraduate courses Europe inquiring their course programme, teaching content and strategies, interest in...
All commercially available triamcinolone acetonide (TACA) suspensions, used for intravitreal treatment, contain retinal toxic vehicles (e.g., benzyl alcohol, solubilizer). Our aim was to find a convenient and reproducible method compound completely preservative-free TACA suspension, adapted the intraocular physiology, with consistent quality (i.e., proven sterility stability, constant content dose uniformity, defined particle size, 1 year shelf life).We evaluated two published...
Abstract Purpose To prospectively assess and compare two formulations methods of administration low‐dose nasal midazolam for the treatment claustrophobic patients undergoing magnetic resonance imaging (MRI) as part a multicenter Phase III trial. Materials Methods In all, 108 consecutive adult were randomly assigned to one groups (multidose group: MDG, unit‐dose UDG). MDG encompassed 55 who received intranasally 0.5% formulation into each nostril (total dose, 1.0 mg), whereas 53 in UDG 1%...
The call by the Institute for Quality and Efficiency in Health Care (IQWiG) randomised controlled trials (RCTs) to prove patient-relevant benefit of positron emission tomography (PET) is currently a controversial topic Germany. From methodological point view there essentially no difference between diagnostic procedures therapeutic (drug or non-drug) interventions proving their causal benefit. A broad consensus has been reached since 1960s (e.g. FDA regulations) that RCTs are gold standard...
Steady-state pharmacokinetics of carumonam were investigated in twelve healthy adult male volunteers after 20 min intravenous infusions three consecutive dosage regimens: 1 g every 8 h (3 g/day) from 0-72 h, 2 (6 88-120 and 6 (8 132-216 h. Serial plasma samples collected the first dose regimen last all regimens analysed for by a specific HPLC method. The overall mean maximal concentrations 108 211 mg/l at end infusion g, respectively. steady-state pharmacokinetic parameters...
Introduction: About 6–10% of all occurring adverse drug reactions result from drug-drug interactions [1,2]. This incidence increases in the presence risk factors, such as age or genetic constitution. Many harmful are preventable, and TDM is an effective tool that. Case reports: The following two cases illustrate need for TDM. 1) A 68 years old schizophrenic patient suffered a paralytic ileus due to clozapine intoxication (clozapine 1732ng/ml, recommended: 350–600ng/ml) after installing...