A5079797502- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Pregnancy and Medication Impact
- HIV/AIDS drug development and treatment
- Cannabis and Cannabinoid Research
- Thyroid Disorders and Treatments
- Trace Elements in Health
- Metabolism and Genetic Disorders
- Context-Aware Activity Recognition Systems
- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Hormonal Regulation and Hypertension
- Lipoproteins and Cardiovascular Health
- Pregnancy and preeclampsia studies
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Colorectal Cancer Treatments and Studies
- Tryptophan and brain disorders
- Coronary Interventions and Diagnostics
- Amino Acid Enzymes and Metabolism
- Neonatal Health and Biochemistry
University of Basel
2016-2025
University Hospital of Basel
2019
Western University
2008-2018
Klinikum Braunschweig
2009-2017
Creative Commons
2016
Universitätsmedizin Greifswald
2010-2014
Universität Greifswald
2004-2014
Institute of Pharmacology
2014
GTx (United States)
2014
University of Bergen
2014
A recent genome-wide study revealed an association between variation in the PNPLA3 gene and liver fat content. In addition, single-nucleotide polymorphism rs738409 (M148I) was reported to be associated with advanced alcoholic disease alcohol-dependent individuals of Mestizo descent. We therefore evaluated impact on manifestation two independent German cohorts. Genotype allele frequencies were determined 1,043 patients or without injury 376 at-risk drinkers from a population-based cohort....
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, are important drugs used in the treatment and prevention of cardiovascular disease. Although statins well tolerated, many patients develop myopathy manifesting as muscle aches pain. Rhabdomyolysis is a rare but severe toxicity statins. Interindividual differences activities hepatic membrane drug transporters metabolic enzymes known to influence statin plasma pharmacokinetics risk for myopathy. Interestingly, little...
renal elimination of a number cationic compounds is thought to be mediated by the organic cation transporter 2 (OCT2, SLC22A2), drug uptake expressed at basolateral domain tubular cells. Recently, key efflux for secretion cations was identified as an electroneutral H + /organic exchanger termed multidrug and toxin extrusion (MATE)-type 1 (MATE1, SLC47A1). The goals this study were assess interplay between transporters OCT2 MATE1 functional assessment genetic variation in human MATE1. First,...
Psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive anxiety disorders, which concomitant with selective serotonin reuptake inhibitors (SSRIs) is prevalent. The present study acute response to single doses LSD (100 μg) after daily administration paroxetine (10 mg 7 days, followed by 20 35 days) or placebo (42 using a randomized, double‐blind, cross‐over design in 23 healthy participants. Paroxetine did not alter...
MRP2 (ABCC2) is an ATP-binding cassette (ABC)-type membrane protein involved in transport of conjugates various drugs and endogenous compounds. has been localized to the apical syncytiotrophoblasts assumed be diaplacental transfer above substances. It shown that both genetic environmental factors can influence <i>MRP2</i> expression. We therefore investigated whether gestational age, cellular differentiation, polymorphisms expression localization 58 human placenta samples. detected a...
Epidermal growth factor (EGF) is a multifunctional known to play major role in proliferation and differentiation processes. EGF-induced prerequisite for function of various cell types, among them cytotrophoblasts, functionally important cellular fraction human placenta. Stimulation cytotrophoblasts with EGF results formation multinuclear syncytium representing the feto-maternal interface, which protects fetus against exogenous substances. It well established that part this protection system...
Abstract The ligand-activated nuclear receptor pregnane X (PXR) is known to play a role in the regulated expression of drug metabolizing enzymes and transporters. Recent studies suggest potential clinically relevant PXR breast cancer. However, pathway or target genes cancer biology progression have not yet been fully clarified. In this study, we show that mRNA organic anion transporter polypeptide 1A2 (OATP1A2), capable mediating cellular uptake estrogen metabolites, nearly 10-fold greater...
The human placenta has both protective and nurturing functions for the fetal organism. Uptake elimination of xenobiotics endogenous substances are facilitated by various transport proteins from solute carrier (SLC) ABC families, respectively. A functional interaction uptake elimination, which is a prerequisite vectorial across cellular barriers, not been described placenta. In this study, we examined expression organic anion transporter (OAT) 4 (SLC22A11), transporting polypeptide (OATP) 2B1...
Organic anion-transporting polypeptides (OATP) 1B1 and 1B3 are widely acknowledged as important rate-limiting to the hepatic uptake of many drugs in clinical use. Accordingly, better understand vivo relevance OATP1B transporters, targeted disruption murine <i>Slco1b2</i> gene was carried out. It is noteworthy that <i>Slco1b2</i>(-/-) mice were fertile, developed normally, exhibited no overt phenotypic abnormalities. We confirmed loss Oatp1b2 expression liver using real-time polymerase chain...
Background— To date, the uptake of drugs into human heart by transport proteins is poorly understood. A candidate protein organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent for carnitine. We investigated expression and localization OCTN2 in heart, OCTN2, functional coupling with eliminating ATP-binding cassette (ABC) ABCB1 (P-glycoprotein). Methods Results— Messenger RNA levels were analyzed samples quantitative polymerase chain reaction....
Associations between thyroid function and hepatic steatosis defined by enzymatic sonographic criteria are largely unknown in the general population. Thus, aim of present study was to investigate association tests as well liver status a large population-based study, Study Health Germany (SHIP).Data from 3661 SHIP participants without self-reported history or disease were analyzed. Hepatic presence hyperechogenic ultrasound pattern increased serum alanine transferase concentrations. Serum...
Increased serum prolactin (PRL) concentrations have been associated with adverse cardiovascular risk profiles, but the relation between PRL and mortality is unknown. We evaluated 3929 individuals (1946 men 1983 women) aged 20–81 (mean 50.3 years) from population-based Study of Health in Pomerania (SHIP). Associations continuous [per standard deviation (SD) increase] categorized (sex-specific tertiles) all-cause cause-specific were analysed separately for women by age- multivariable-adjusted...
Falls are a predominant problem in our aging society, often leading to severe somatic and psychological consequences, having an incidence of about 30% the group persons aged 65 years or above. In order identify at risk, many assessment tools tests have been developed, but most these be conducted supervised setting dependent on expert rater.The overall aim research work is develop objective unobtrusive method determine individual fall risk based use motion sensor data. The aims for this paper...
Objective The uptake carrier organic anion-transporting polypeptide 1B3 (OATP1B3, gene SLCO1B3) is involved in the hepatic clearance of xenobiotics including statins, taxanes, and mycophenolic acid. We thought to assess SLCO1B3 coding region for yet unidentified polymorphisms analyze their functional relevance. Methods used DNA ethnically diverse individuals polymerase chain reaction, determined by sequencing or temperature-dependent capillary electrophoresis. then created variant OATP1B3...
The FKBP5 gene codes for a co-chaperone that regulates glucocorticoid receptor sensitivity and thereby impacts the reactivity of hypothalamic-pituitary-adrenal (HPA)-axis. Evidence suggested subjects exposed to childhood abuse carrying TT genotype single nucleotide polymorphism (SNP) rs1360780 have an increased susceptibility stress-related disorders.The hypothesis abused carriers show changes in gray matter (GM) volumes affect-processing brain areas was investigated. About 1,826 Caucasian...