A5009826939- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Metabolism and Genetic Disorders
- EEG and Brain-Computer Interfaces
- Multiple Sclerosis Research Studies
- Genetics and Neurodevelopmental Disorders
- Mitochondrial Function and Pathology
- Genomics and Rare Diseases
- Cerebrospinal fluid and hydrocephalus
- Glycogen Storage Diseases and Myoclonus
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Glioma Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Restless Legs Syndrome Research
- Polyomavirus and related diseases
- Functional Brain Connectivity Studies
- Syphilis Diagnosis and Treatment
- Trace Elements in Health
- Bipolar Disorder and Treatment
- Reproductive tract infections research
- Genetic Neurodegenerative Diseases
University of Belgrade
2016-2025
Univerzitetski Klinički Centar Srbije
2002-2025
Centar za Promociju Nauke
2012-2024
University of Belgrade – Faculty of Medicine
2014-2015
Oncology Institute of Vojvodina
2010
University Clinical Centre
1990-2003
To evaluate the efficacy and safety of perampanel 2, 4, 8 mg/day added to 1-3 concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures.During this double-blind, placebo-controlled trial, persisting seizures on AEDs were randomized or placebo following a 6-week baseline phase. Perampanel was titrated weekly by 2 maintained at dose achieved for 13 weeks. Primary endpoints median percent change seizure frequency 50% responder rate. Analysis covariance...
Summary: Purpose: In patients with multiple sclerosis (MS), epileptic seizures occur more frequently than in the general population. The aim of this study was to analyze clinical characteristics epilepsy MS, potential correlation between semiology seizures, EEG and magnetic resonance imaging (MRI) findings these patients, as well examine response anticonvulsant therapy. Methods: a series 268 consecutive definite MS hospitalized at Institute Neurology, Belgrade, we identified 20 (7.5%) or...
In a consecutive series of 169 outpatients with Parkinson9s disease the frequency depression was compared in two groups: those who developed before age 50, and after 50. Major found 36% patients early onset 16% late disease. This significant difference disappeared when both groups were matched for duration A stepwise regression analysis showed correlation only between scores impairment activities daily living.
Summary: Purpose: We report the frequency of parkinsonism and cognitive decline (P/CD) in patients treated with valproate (VPA) after 1 year treatment at least follow‐up. Methods: Three hundred sixty‐four various epileptic syndromes seizure types were VPA mono‐ or polytherapy for more than year. Results: found five cases P/CD (1.37%; 95% CI, 0.18–2.56%). Among 140 different adverse effects (AEs) VPA, among rarest but significant terms drug discontinuation (five 17). Conclusions: Early...
Background/Objectives: Functional seizures (FSs) are paroxysmal, time-limited events with motor, sensory, autonomic, or cognitive manifestations related to pathophysiological processes other than abnormal electric discharges in the brain. However, these often followed by different psychiatric comorbidities. Their impact on overall quality of life and cofounding factors, especially ones that can be treated, were main investigation aims this study. Methods: This study comprised 76 patients who...
Summary Objective To examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated hippocampal sclerosis (mTLE‐HS). Methods Activity and levels enzymes—catalase (CAT), glutathione peroxidase (GPx), reductase (GR), manganese superoxide dismutase (MnSOD), copper‐zinc (CuZnSOD)—were assessed nine pharmacoresistant mTLE‐HS (mean age 37.7 ± [standard deviation] 6.6 years) who underwent amygdalohippocampectomy, 10 obtained via autopsy from five neurologically...
Background:The diagnosis of epilepsy primarily depends on description the observed seizure. The aim this study was to determine reliability witness' among groups with different medical education.Methods:A group 44 respondents (15 laymen, 15 students, and 14 doctors at neurology residency program) were shown video footages focal epileptic seizure (ES) secondary generalization psychogenic non-epileptic (PNES) same patient. ability describe ES PNES characteristics, estimate duration seizures,...
To determine long-term survival in patients with status epilepticus (SE).We prospectively followed admitted for the first (69.6%) or recursive episode of SE between January 1, 1989 and December 31, 1997 at Institute Neurology, Belgrade, Serbia, until death study termination (December 2006). Data were obtained cause death; etiology SE-acute symptomatic (AS), progressive (PS), remote (RS), idiopathic/cryptogenic (I/C); presence epilepsy; reoccurrence SE. Standardized mortality rate (SMR),...
Purpose: The application of artificial neural networks in the pharmaceutical sciences is broad, ranging from drug discovery to clinical pharmacy. In this study, we explored applicability counter-propagation (CPANNs), combined with genetic algorithm (GA) for prediction topiramate (TPM) serum levels based on identified factors important its prediction. Methods: study was performed 118 TPM measurements obtained 78 adult epileptic patients. Patients were stable dosing regimen at least 7 days;...
Summary Background: To get more insight into the effects of most widely used antiepileptic drugs (AEDs) on prooxidant/ antioxidant balance in epilepsy, a comparative analysis byproducts oxidative damage and de fense mechanisms was performed patients with epilepsy treated lamotrigine, carbamazepine valproic acid. Methods: Byproducts to proteins (reactive carbonyl derivatives, RCD protein thiol groups, PSH), lipids (urinary isoprostanes, 8-epi-PGF2a) DNA 8-hydroxy-2’-deoxyguanosine, 8-OHdG),...