Luca De Palma
A5001020536- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Tuberous Sclerosis Complex Research
- Fetal and Pediatric Neurological Disorders
- Genomics and Rare Diseases
- Neural dynamics and brain function
- Metabolism and Genetic Disorders
- Advanced Neuroimaging Techniques and Applications
- Genomic variations and chromosomal abnormalities
- Neuroscience and Neural Engineering
- Autoimmune Neurological Disorders and Treatments
- Neurological disorders and treatments
- Glycogen Storage Diseases and Myoclonus
- Dermatological and Skeletal Disorders
- Hedgehog Signaling Pathway Studies
- Ion channel regulation and function
- Vagus Nerve Stimulation Research
- RNA and protein synthesis mechanisms
Bambino Gesù Children's Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Stichting Epilepsie Instellingen Nederland
2024
University of Amsterdam
2024
Amsterdam Neuroscience
2024
University Medical Center Utrecht
2024
Centre Hospitalier Universitaire de Grenoble
2012-2020
Laboratoire de Psychologie et NeuroCognition
2020
Hôpital Albert Michallon
2014-2017
Inserm
2014-2017
Sturge-Weber Syndrome (SWS) is a rare, sporadic neurocutaneous disorder affecting the skin, brain, and eyes, due to somatic activating mutations in GNAQ or, less commonly, GNA11 gene. It characterized by at least two of following features: facial capillary malformation, leptomeningeal vascular ocular involvement. The spectrum clinical manifestations includes headache, seizures, stroke-like events, intellectual disability, glaucoma, asymmetry, gingival hyperplasia, etc. An early diagnosis...
Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is cortical dysplasia (FCD). FCD challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for detection are limited by high numbers false-positive predictions, hampering their clinical utility. Objective To evaluate the efficacy interpretability graph neural networks in automatically detecting lesions on MRI scans. Design, Setting, Participants In this...
In patients with pharmaco-resistant focal epilepsies investigated intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. 2013, we proposed new probabilistic functional tractography methodology study human We have now been revisiting this method the F-TRACT project (f-tract.eu) by developing multicenter CCEP...
Abstract One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on MRI but often amenable surgical resection. We aimed develop an open-source, interpretable, surface-based machine-learning automatically identify heterogeneous data epilepsy surgery centres worldwide. The Multi-centre Epilepsy...
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared lesional patients. In this study, we aimed to characterize large group patients who underwent despite normal and had no lesion histopathology. Determinants their postoperative seizure outcomes were further studied.
Summary PCDH 19 gene mutations have been recently associated with an epileptic syndrome characterized by focal and generalized seizures. The (Xq22.1) has unusual X‐linked inheritance a selective involvement for female subjects. A cellular interference mechanism hypothesized male patients can manifest epilepsy only in the case of mosaicism. So far about 100 patients, one symptomatic described. Using targeted next generation sequencing ( NGS ) approach we found point mutation two clinical...
To assess seizure and cognitive outcomes their predictors in children (<16 years at surgery) adults undergoing temporal lobe epilepsy (TLE) surgery eight Italian centers.This is a retrospective multicenter study. We performed descriptive analysis subsequently carried out multivariable mixed-effect models corrected for multiple comparisons.We analyzed data from 511 patients (114 children) observed significant differences several clinical features between children. The possibility of achieving...
This study aimed to identify early clinical, magnetic resonance imaging (MRI), and electroencephalographic (EEG) characteristics of neuronal ceroid lipofuscinosis type 2 (CLN2) disease enable diagnosis, thus providing the key treatment, optimized care outcomes.Retrospective clinical chart review a series patients diagnosed with CLN2 from 2005 2015 at single center in Italy. Clinical, MRI, EEG findings were reviewed.A total 14 included. For whole group, median (range) age onset was 3.0...
Summary Objective To assess long‐term outcome and identify prognostic factors of radiofrequency thermocoagulation ( RFTC ) following stereoelectroencephalography SEEG explorations in particularly complex cases focal epilepsy. Methods We retrospectively reviewed the medical charts, video‐ recordings, outcomes for 23 patients (aged 6–53 years) treated with ‐guided , whom 15 had negative magnetic resonance imaging MRI findings, 10 were considered noneligible resective surgery after . Two to 11...
Summary Objective To analyze the attitude and results of Italian epilepsy surgery centers in surgical management “low grade associated neuroepithelial tumors” ( LEAT s). Methods We conducted a retrospective study enrolling 339 consecutive patients with s who underwent between January 2009 June 2015 at eight centers. compared demographic, clinical, pathologic, features favorable (Engel class I) unfavorable II , III, IV ) seizure outcome. In addition, we tumor‐associated focal cortical...
Summary Objective PCDH 19‐related epilepsy is an epileptic syndrome with infantile onset, characterized by clustered and fever‐induced seizures, often associated intellectual disability ( ID ) autistic features. The aim of this study was to analyze a large cohort patients better define the phenotype, genotype‐phenotype correlations, related outcome‐predicting factors. Methods We retrospectively collected genetic, clinical, electroencephalogram EEG data 61 followed at 15 centers. All...
To contribute to characterize electroencephalographic (EEG) activity in pediatric anti- N-methyl-d-aspartate (anti-NMDA) receptor encephalitis, we reviewed electroclinical data of 5 children with anti-NMDA encephalitis diagnosed our department. We identified 4 longitudinal phases: the early phase, background was normal, intermixed nonreactive slow waves; florid deteriorated appearance sequences peculiar rhythmic theta and/or delta unrelated clinical changes, unresponsive stimuli and...