A5083305126- Epilepsy research and treatment
- Dutch Social and Cultural Studies
- Tuberous Sclerosis Complex Research
- Pharmacological Effects and Toxicity Studies
- Genomics and Rare Diseases
- Hedgehog Signaling Pathway Studies
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Environmental Policies and Emissions
- Evaluation and Performance Assessment
- Genomic variations and chromosomal abnormalities
- Tumors and Oncological Cases
- Genetic and Kidney Cyst Diseases
- Cardiac electrophysiology and arrhythmias
- Taxation and Legal Issues
- Economic Analysis and Policy
- Research in Social Sciences
- Gastroesophageal reflux and treatments
- Legal Issues in South Africa
- Environmental Conservation and Management
- Public-Private Partnership Projects
- Fetal and Pediatric Neurological Disorders
University Medical Center Utrecht
2017-2024
Stichting Epilepsie Instellingen Nederland
2024
University of Amsterdam
2024
Amsterdam Neuroscience
2024
Epilepsy Foundation
2010
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared lesional patients. In this study, we aimed to characterize large group patients who underwent despite normal and had no lesion histopathology. Determinants their postoperative seizure outcomes were further studied.
To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015.We collected information on volumes types surgery, pathology, seizure outcome from 20 recognized reference centers 10 countries.We analyzed retrospective aggregate data 1859 operations. The proportion surgeries significantly increased over time (P < .0001). Engel class I was achieved 69.3% children, with no significant improvement 2015. histopathological findings consistent glial scars the ages...
Genetic causes are increasingly identified in patients with focal epilepsy. These genetic may be related to the effectiveness of epilepsy surgery. We aimed assess use and yield testing a large cohort who were evaluated for surgery.We performed retrospective single-center consecutive study surgery between 1990 2016. Within this cohort, we assessed testing-either before or after presurgical decision-making. results as well outcome decision-making surgery, compared these end points different...
We studied the distribution of germline and somatic variants in epilepsy surgery patients with (suspected) malformations cortical development (MCD) who underwent between 2015 2020 at University Medical Center Utrecht (the Netherlands) pooled our data four previously published cohort studies. Tissue analysis yielded a pathogenic variant 203 663 (31%) combined cases. In 126 379 (33%) focal dysplasia (FCD) type II cases 23 37 (62%) hemimegalencephaly cases, was identified, mostly involving mTOR...
Meer dan de helft van patiënten met een GATOR1 pathogene variant heeft therapieresistente epilepsie. Als focale corticale dysplasie aanwezig is, of uitgebreid prechirurgisch onderzoek epileptogene zone duidelijk te identificeren en afgrensbaar blijkt, kan chirurgische resectie optie zijn. Echter, voor deel deze ontbreken vooralsnog effectieve therapieën. Voor hen mTOR remming veelbelovende vorm precisiebehandeling zijn, die ‘n-of-1’ studie worden onderzocht.