Francesco Deleo
A5053193830- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Autoimmune Neurological Disorders and Treatments
- Neonatal and fetal brain pathology
- EEG and Brain-Computer Interfaces
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Head and Neck Surgical Oncology
- Genetics and Neurodevelopmental Disorders
- Radiomics and Machine Learning in Medical Imaging
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Peripheral Neuropathies and Disorders
- Neurobiology of Language and Bilingualism
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Glycogen Storage Diseases and Myoclonus
- Ion Transport and Channel Regulation
- Brain Tumor Detection and Classification
- Advanced MRI Techniques and Applications
Fondazione IRCCS Istituto Neurologico Carlo Besta
2016-2025
Stichting Epilepsie Instellingen Nederland
2024
University of Amsterdam
2024
Amsterdam Neuroscience
2024
University of Florence
2022-2024
Brazilian Institute of Neuroscience and Neurotechnology
2024
Universidade Estadual de Campinas (UNICAMP)
2022-2024
Meyer Children's Hospital
2022-2024
University Medical Center Utrecht
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023
ABSTRACT Pre‐surgical and post‐surgical data were examined compared from 215 consecutive patients undergoing surgery for intractable epilepsy. Patients selected on the basis of a proven histopathological diagnosis type I focal cortical dysplasia (FCD I), alone or associated with other lesions. The divided into five sub‐groups: i) 66 isolated FCD I, ii) 76 hippocampal sclerosis, iii) 49 tumours, iv) 16 malformations development v) eight anoxic‐ischaemic inflammatory diseases. duration...
ABSTRACT Focal cortical dysplasias (FCDs) are highly epileptogenic malformations associated with drug‐resistant epilepsy, susceptible to surgical treatment. Among the different types of FCD, type II includes two subgroups based on absence (IIa) or presence (IIb) balloon cells. The aim this retrospective study was investigate possible differences in electroclinical presentations and outcomes between 100 consecutive surgically treated patients FCDs. All underwent a comprehensive presurgical...
Magnetic resonance imaging-positive temporal lobe atrophy with temporo-polar grey/white matter abnormalities (usually called 'blurring') has been frequently reported in patients epilepsy associated hippocampal sclerosis. The poor distinction of grey and white attributed to various causes, including developmental cortical abnormalities, gliosis, myelin alterations, a non-specific increase water content metabolic/perfusion alterations. However, there is still no consensus regarding the genesis...
To test the hypothesis that a multicenter-validated computer deep learning algorithm detects MRI-negative focal cortical dysplasia (FCD).We used clinically acquired 3-dimensional (3D) T1-weighted and 3D fluid-attenuated inversion recovery MRI of 148 patients (median age 23 years [range 2-55 years]; 47% female) with histologically verified FCD at 9 centers to train convolutional neural network (CNN) classifier. Images were initially deemed in 51% patients, whom intracranial EEG determined...
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared lesional patients. In this study, we aimed to characterize large group patients who underwent despite normal and had no lesion histopathology. Determinants their postoperative seizure outcomes were further studied.
ABSTRACT The present study included analysis of data from 243 patients surgically treated for Temporal Lobe Epilepsy (TLE). Resection was confined to the temporal lobe, with at least two years follow‐up, and specimens sufficiently preserved allow a precise evaluation both lateral neocortex hippocampus. frequency different types lesion hippocampal sclerosis (HS), isolated or associated neocortical lesions, risk factors surgical outcomes in relation neuropathological findings were evaluated....
Hippocampal sclerosis (HS) is the most frequent neuropathologic finding in patients undergoing surgery for intractable temporal lobe epilepsy (TLE). The International League Against Epilepsy (ILAE) has recently proposed a new classification of HS based on specific patterns cell loss. aim this study was to investigate relationships between types, their etiologic factors, and short- long-term postsurgical outcomes because drug-resistant TLE with HS.Two hundred thirteen diagnosis minimum...
In patients with temporal lobe epilepsy (TLE), assessment of language lateralization is important as anterior lobectomy may lead to impairments. Despite the widespread use fMRI, evidence its usefulness in predicting postsurgical performance scant. We investigated whether preoperative functional related performance, peri-ictal aphasia, and can predict outcome one year post-surgery. studied a total 72 TLE (42 left, 30 right), by using three fMRI tasks: Naming, Verb Generation Fluency....
Abstract Neuronal dendritic arborizations and spines are crucial for a normal synaptic transmission may be critically involved in the pathophysiology of epilepsy. Alterations morphology spine loss mainly hippocampal neurons have been reported both epilepsy animal models human brain tissues from patients with However, it is still unclear whether these abnormalities relate to cause or generated by seizure recurrence. We investigated fine neuronal structures at level organization using Golgi...
In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed a naturalistic setting are useful complement to characterize the drug profile. This multicentre study assessed effectiveness and tolerability of adjunctive BRV large population epilepsy context real-world clinical practice. The BRIVAFIRST (BRIVAracetam First Italian netwoRk STudy) was retrospective, including adult prescribed BRV. Patients...
OBJECTIVE Epilepsy surgery is an effective means of treating focal epilepsy associated with long-term epilepsy-associated tumors. This study evaluated a large population surgically treated patients childhood onset and histologically confirmed diagnosis The authors analyzed seizure outcomes to establish whether the time patients' ages were determinant factors. METHODS separately investigated several presurgical, surgical, postsurgical variables in operated on before (pediatric group) at or...
Objective The contribution of recurring seizures to the progression epileptogenesis is debated. Seizure‐induced brain damage not conclusively demonstrated either in humans or animal models epilepsy. We evaluated expression injury biomarkers on postsurgical tissue obtained from 20 patients with frequent and a long history drug‐resistant focal Methods patterns specific glial, neuronal, inflammatory molecules were by immunohistochemistry core type II cortical dysplasias (FCD‐II), at FCD...
Objective To describe the clinical and paraclinical findings, treatment options long-term outcomes in autoimmune encephalitis (AE), with a close look to epilepsy. Methods In this retrospective observational cohort study, we enrolled patients new-onset seizures context of AE. We compared findings without evidence antibodies. Results Overall, 263 (138 females; median age 55 years, range 4–86) were followed up for time 30 months (range 12–120). Antineuronal antibodies detected 63.50%....
This retrospective study assessed long-term effectiveness of add-on perampanel (PER) in patients with Lennox-Gastaut syndrome (LGS). Outcomes included time to PER failure and seizure relapse responders. was defined as either discontinuation or initiation another treatment. Seizure responders occurrence a seizure-free increase at least 50% average monthly frequency for those who were Eighty-seven included. Treatment occurred 52 (59.8%) subjects median 12 months. due lack efficacy 27 (52.0%)...
Abstract The identification of the epileptogenic zone (EZ) boundaries is crucial for effective focal epilepsy surgery. We verify value a neurophysiological biomarker ictogenesis, characterized by low‐voltage fast‐activity ictal pattern (chirp) recorded with intracerebral electrodes during invasive presurgical monitoring (stereoelectroencephalography [SEEG]). frequency content SEEG signals was retrospectively analyzed semiautomatic software in 176 consecutive patients epilepsies that either...
Abstract Focal cortical dysplasia (FCD) type II is a highly epileptogenic developmental malformation and common cause of surgically treated drug-resistant epilepsy. While clinical observations suggest frequent occurrence in the frontal lobe, mechanisms for such propensity remain unexplored. Here, we hypothesized that cortex-wide spatial associations FCD distribution with cytoarchitecture, gene expression organizational axes may offer complementary insights into processes predispose given...
Summary Objective Several studies have reported that inhibitory networks are altered in dysplastic tissue obtained from epilepsy surgery specimens. A consistent decrease the number of interneuronal subpopulation expresses parvalbumin ( PV ) was postsurgical patients with focal cortical dysplasia FCD ). We tested if protein expression observed epileptic corresponds to a parallel impairment γ‐aminobutyric acid GABA )ergic compartment. Methods analyzed 30 surgically treated who underwent for...
Summary Objective Because temporal lobe epilepsy ( TLE ) can impair theory of mind (ToM), we examined the effects anterior lobectomy ATL by comparing preoperative to postoperative ToM course with that other cognitive functions characteristically impaired in . Methods Eighty‐five patients left (n = 39) or right 46) drug‐resistant and an age at onset >12 54) ≤12 years 31) were evaluated before 1 year after surgery; 40 healthy controls assessed baseline. The participants' recognition...
Lombardy was severely hit by the COVID-19 pandemic since February 2020 and Health System underwent rapid reorganization. Outpatient clinics were stopped for non-urgent patients: it became a priority to manage hundreds of fragile neurological patients who suddenly had less reference points. In Italy, before pandemic, Televisits neither recognized nor priced. At Fondazione IRCCS Istituto Neurologico C. Besta, we reorganized outpatient deliver Neuro-telemedicine services, including...