Giacomo Fisco
A5033595802- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Ophthalmology and Eye Disorders
- Infectious Encephalopathies and Encephalitis
- Long-Term Effects of COVID-19
- Sexual Differentiation and Disorders
- Hemoglobinopathies and Related Disorders
- Metabolism and Genetic Disorders
- Cerebral Venous Sinus Thrombosis
- Neurological disorders and treatments
- Pharmaceutical studies and practices
- Ocular Diseases and Behçet’s Syndrome
- Multiple Sclerosis Research Studies
- Pregnancy and Medication Impact
- Adrenal Hormones and Disorders
- Psychosomatic Disorders and Their Treatments
- Genetics and Neurodevelopmental Disorders
Sapienza University of Rome
2019-2022
Policlinico Umberto I
2019-2022
Centro Neurolesi Bonino Pulejo
2022
Abstract Objective Valproate (VPA) use in women with idiopathic generalized epilepsy (IGE) who are of reproductive age has been a matter concern and debate, which eventually led to the recent restrictions by regulatory agencies. The aim our study was investigate relationship between VPA avoidance/switch seizure outcome childbearing potential. Methods We retrospectively reviewed data from female patients IGE, 13‐50 years age, followed since 1980. evaluated prescription habits, rate switch for...
In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed a naturalistic setting are useful complement to characterize the drug profile. This multicentre study assessed effectiveness and tolerability of adjunctive BRV large population epilepsy context real-world clinical practice. The BRIVAFIRST (BRIVAracetam First Italian netwoRk STudy) was retrospective, including adult prescribed BRV. Patients...
To assess prognostic patterns and investigate clinical electroencephalography (EEG) variables associated with persistent treatment resistance in a population of genetic generalized epilepsy (GGE) patients long-term follow-up.Data from GGE followed 1975 to 2019 were reviewed retrospectively. Subjects follow-up >10 years, starting diagnosis, included. Persistent was defined as the absence any period remission ≥1 year despite two appropriate adequate antiepileptic drugs (AEDs).One hundred...
Subjects with intellectual disability are usually excluded from clinical trials and there is limited evidence-based guidance for the choice of antiseizure medications in this vulnerable population. The study explored effectiveness brivaracetam (BRV) people epilepsy disability. BRIVAracetam add-on First Italian netwoRk Study (BRIVAFIRST) was a 12-month retrospective, multicenter including adults prescribed adjunctive BRV. Main outcomes included rates seizure‐freedom, seizure response (≥ 50%...
The management of epilepsy in older adults has become part daily practice because an aging population. Older patients with represent a distinct and more vulnerable clinical group as compared younger patients, they are generally under-represented randomized placebo-controlled trials. Real-world studies can therefore be useful complement to characterize the drug's profile. Brivaracetam is rationally developed compound characterized by high-affinity binding synaptic vesicle protein 2A approved...
In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Most real-world research on BRV has focused refractory The aim of this analysis was to assess the 12-month effectiveness and tolerability adjunctive when used as early or late treatment included BRIVAracetam First Italian netwoRk Study (BRIVAFIRST). BRIVAFIRST a retrospective, multicenter study including adult prescribed BRV. Effectiveness outcomes rates...
Hydrocortisone (HC) despite a low aqueous solubility and very poor palatability is frequently used unlicensed in paediatric practice. Hence reconstitutable taste masked hydrocortisone solution with the potential to be easily produced extemporaneously was developed. Excipients for dry powder mix were selected based on their solubility, compatibility, safety profile children stability at optimum pH HC. Formulations visually inspected checked. The chemical microbiological assessed by validated...
Objectives To investigate the aetiology of acute-onset binocular diplopia (AOBD) in neurological units and identify key diagnostic procedures this setting. Materials methods Clinico-demographic data from patients hospitalized for AOBD 2008 to 2019 were retrospectively reviewed. due an underlying disorder known cause was addressed as secondary diplopia. Ophthalmoparesis plus defined when subtle signs/symptoms other than ophthalmoparesis detected during examination. Results A total 171 (mean...
Adverse events occurring after SARS-CoV-2 vaccination have been reported and are the subject of ongoing research. We present case a young woman with fully reversible radiculomyelitis, which happened first dose ChAdOx1 nCOVID-19 vaccine. A previously healthy in her 20s presented subacute onset legs’ weakness sensory disturbances, urinary dysfunction cramping pain receiving nCoV-19 diagnostic workup led to diagnosis inflammatory radiculomyelitis. Her clinical status improved, complete recovery...