A5020015006- Peripheral Neuropathies and Disorders
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Neurological Disorders and Treatments
- Electroconvulsive Therapy Studies
- Bipolar Disorder and Treatment
- Electrolyte and hormonal disorders
- Multiple Sclerosis Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Long-Term Effects of COVID-19
- Epilepsy research and treatment
- Mechanical Circulatory Support Devices
- Neurogenetic and Muscular Disorders Research
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
- Atrial Fibrillation Management and Outcomes
- Ocular Diseases and Behçet’s Syndrome
- Infectious Encephalopathies and Encephalitis
- Kawasaki Disease and Coronary Complications
- Acute Lymphoblastic Leukemia research
- Retinal and Optic Conditions
- IL-33, ST2, and ILC Pathways
- Pharmacological Effects and Toxicity Studies
- Dermatological and Skeletal Disorders
- Multiple Myeloma Research and Treatments
- Parvovirus B19 Infection Studies
Fondazione IRCCS Istituto Neurologico Carlo Besta
2020-2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2023
King's College London
2022
Guy's and St Thomas' NHS Foundation Trust
2022
Evelina London Children's Healthcare
2022
University of Insubria
2019
Policlinico San Matteo Fondazione
2015
Istituti di Ricovero e Cura a Carattere Scientifico
2015
<h3>Background and Objectives</h3> We sought to identify early factors associated with relapse outcome in paediatric-onset myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD). <h3>Methods</h3> In a multicenter retrospective cohort of pediatric MOGAD (≤18 years), onset features treatment were compared patients monophasic vs relapsing disease (including cases follow-up ≥12 months after or at any time) final Expanded Disability Status Scale (EDSS) 0 ≥1 last >3 event...
Background Cerebrospinal fluid myelin oligodendrocyte glycoprotein IgG (CSF MOG-IgG) are found in a proportion of patients with MOG antibody-associated disorder (MOGAD) and have been associated severe disease presentations. However, most studies did not systematically investigate the role MOG-IgG intrathecal synthesis (ITS). Methods We retrospectively studied 960 consecutive paired serum CSF samples screened for using live cell-based assays. MOG-IgG-specific antibody index (AI ) was...
Key Points Human ILC1-like cells kill tumors in a KIR-independent manner. The cytotoxicity of human is impaired AML at diagnosis but restored remission.
Lombardy was severely hit by the COVID-19 pandemic since February 2020 and Health System underwent rapid reorganization. Outpatient clinics were stopped for non-urgent patients: it became a priority to manage hundreds of fragile neurological patients who suddenly had less reference points. In Italy, before pandemic, Televisits neither recognized nor priced. At Fondazione IRCCS Istituto Neurologico C. Besta, we reorganized outpatient deliver Neuro-telemedicine services, including...
Griscelli syndrome type 2 (GS2) is a life-threatening disease caused by mutations in the RAB27A gene. It characterized partial albinism association with systemic immunological abnormalities leading to hemophagocytic lymphohistiocytosis (HLH). Variable neurological impairment experienced patients suffering from HLH and symptoms can be main manifestations of disease. We describe 3 years-old child relapsing-remitting multifocal encephalomyelopathy mild signs. He was not "albino" even if he had...
Behcet's disease (BD) is a rare vasculitis characterized by multisystemic inflammation. Central nervous system (CNS) involvement and heterogeneous, particularly in the pediatric population. A diagnosis of neuro-Behcet could be highly challenging, especially if neurological manifestations precede other systemic features; however, its timely definition crucial to prevent long-term sequelae. In this study, we describe case girl who, at 13 months age, presented with first episode encephalopathy...
Introduction: Linear immunoglobulin A bullous dermatosis (LABD) is a rare, heterogeneous, autoimmune blistering skin disorder that can be associated with other conditions. Case presentation: We describe the case of 14-year-old Italian boy previously diagnosed ulcerative colitis who presented severe LABD well controlled after appropriate medical therapy and in total remission follow-up one year.