A5090308156- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Neuroscience and Neuropharmacology Research
- Hedgehog Signaling Pathway Studies
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- Fetal and Pediatric Neurological Disorders
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Cancer and Skin Lesions
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Adrenal and Paraganglionic Tumors
Fondazione IRCCS Istituto Neurologico Carlo Besta
2017-2025
University of Bologna
2008-2024
Ospedale Bellaria
2011-2024
Mylan (South Africa)
2024
Universitätsklinikum Erlangen
2022
Azienda USL di Bologna
2010-2018
University of Parma
2018
Institute of Neurological Sciences
2014-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2017
University of Genoa
2017
We have previously shown the usefulness of a new confocal endomicroscopy system (CONVIVO®) in providing quick and reliable method for intraoperative diagnosis ex vivo glioblastoma (GBM). In this study, we aimed to assess CONVIVO® an in-vivo setting, focusing on its capability explore presence residual tumor at resection margins Central Nervous System (CNS) tumors. consecutively enrolled patients submitted fluorescein-guided CNS-tumor removal (May 2020 December 2022). was used obtain images...
O6-methylguanine DNA-methyltransferase (MGMT) promoter methylation status is a prognostic factor in newly diagnosed glioblastoma patients. However, it not yet clear whether, and if so how, MGMT may change. Moreover, unknown whether the role of this epigenetic feature retained during disease course. A retrospective analysis was made using database 614 patients treated prospectively from January 2000 to August 2008. We evaluated only who met following inclusion criteria: age ≥18 years;...
Several biomarkers have been proposed as useful parameters to better specify the prognosis or delineate new target therapy strategies for glioblastoma patients. MicroRNAs could represent putative molecules, considering their role in tumorigenesis, cancer progression and specific tissue expression. Although several studies tried identify microRNA signature glioblastoma, a profile is still far from being well‐defined. In this work expression of 19 microRNAs (miR‐7, miR‐9, miR‐9∗, miR‐10a,...
Abstract The identification of biomarkers the transformation normal to epileptic tissue would help stratify patients at risk epilepsy following brain injury and inform new treatment strategies. MicroRNAs (miRNAs) are an attractive option in this direction. In study, miRNA microarrays were performed on laser-microdissected hippocampal granule cell layer (GCL) plasma, different time points development pilocarpine-induced rat: latency, first spontaneous seizure chronic phase. Sixty-three miRNAs...
OBJECTIVE In the past decade, role of endoscopic endonasal approach (EEA) has relevantly evolved for skull base tumors. this study, authors review their surgical experience with using an EEA in treatment clival chordomas, which are deep and infiltrative lesions, they highlight advantages limitations ventral approach. METHODS All consecutive cases chordoma treated between 1998 2015 at a single institution included study. Preoperative assessment consisted neuroimaging (MRI CT angiography...
The authors retrospectively analyzed and compared seizure outcome in a series of 28 patients with temporomesial glioneuronal tumors associated epilepsy who underwent 1 2 different surgery procedures: lesionectomy or tailored resection.The were divided into groups, 14 cases each group. In Group A, was limited to the tumor (lesionectomy), whereas B resection involving removal epileptogenic zone as identified by neurophysiological noninvasive presurgical study.In A (10 male 4 female patients)...
An International League Against Epilepsy (ILAE) consensus classification system for focal cortical dysplasias (FCDs) has been published in 2011 specifying clinicopathologic FCD variants. The aim of the present work was to microscopically assess interobserver agreement and intraobserver reproducibility categories among an international group neuropathologists with different levels experience access epilepsy surgery tissue.Surgical specimens covering a broad histopathology spectrum were...
Low-grade tumor (LGT) is an increasingly recognized cause of focal epilepsies, particularly in children and young adults, frequently associated with cortical dysplasia. The optimal surgical treatment epileptogenic LGTs pediatric patients has not been fully established.In the present study, authors retrospectively reviewed 30 (age range 3-18 years) who underwent surgery for histopathologically confirmed LGTs, which seizures were only clinical manifestation. divided into 2 groups according to...
Summary Objective To analyze the attitude and results of Italian epilepsy surgery centers in surgical management “low grade associated neuroepithelial tumors” ( LEAT s). Methods We conducted a retrospective study enrolling 339 consecutive patients with s who underwent between January 2009 June 2015 at eight centers. compared demographic, clinical, pathologic, features favorable (Engel class I) unfavorable II , III, IV ) seizure outcome. In addition, we tumor‐associated focal cortical...
The study was performed to investigate the relation between seizure outcome after surgical treatment of mesial temporal lobe epilepsy (MTLE) and pathological findings, classified according recently proposed classifications sclerosis (MTS), granule cell pathology (GCP), focal cortical dysplasia (FCD) epilepsy-associated low-grade tumors (ELGT).The authors analyzed data obtained in 120 consecutive cases involving patients presenting with drug-resistant MTLE, who underwent tailored anteromesial...
Pathological evidence of amyloid on nerve biopsy has been the gold standard for diagnosis in hereditary transthyretin amyloidosis polyneuropathy (hATTR-PN) a long time. In this article, we reviewed pathological findings large series sural biopsies from cohort hATTR-PN patients, collected by different Italian referral centers. Patients and Methods: We clinical data diagnosed followed five centers peripheral neuropathies. Diagnosis was formulated after positive genetic test (TTR) mutations....
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults, but its etiology still remains unknown. Recently, a role of viruses such as cytomegalovirus and JC virus gliomagenesis has been suggested. Since human papillomavirus (HPV) considered common oncogenic humans, we evaluated occurrence GBM samples. Fifty-two formalin-fixed paraffin-embedded primary glioblastoma specimens were retrospectively analyzed. The presence HPV genome on DNA was assessed by MY/GP nested PCR....
The microRNAs (miRNAs) are small size non-coding RNAs that regulate expression of target mRNAs at post-transcriptional level. miRNAs differentially expressed under pathological conditions may help identifying mechanisms underlying the disease and represent biomarkers with prognostic value. However, this kind studies difficult in brain because cellular heterogeneity tissue limited access to fresh tissue. Here, we focused on a pathology affecting specific cells subpopulation epileptic brains...
BRAF alterations, namely fusion and V600E mutation, have been recently reported in low-grade epilepsy-associated tumors. Twenty tumors were retrieved to evaluate the mutational status. mutations present 10 concomitantly associated dysplastic tissue of three patients. We here show for first time that are not only but, some cases, also focal cortical dysplasia.
Abstract Background As yet, no population-based prospective studies have been conducted to investigate the incidence and clinical outcome of glioblastoma (GBM) or diffusion impact current standard therapeutic approach in newly diagnosed patients younger than aged 70 years. Methods Data on all new cases primary brain tumors observed from January 1, 2009, December 31, 2010, adults residing within Emilia-Romagna region were recorded a registry Project Emilia Romagna Neuro-Oncology (PERNO)....