NFDI4DS | UHH-SEMS - Publication Details

Syed Anees Ahmed

ORCID: 0000-0002-0148-5148

Publications

Citations

Views

---

Saved

---

About

Contact & Profiles

A5017298371

Research Areas

Climate Change and Health Impacts
Liver Disease Diagnosis and Treatment
Global Public Health Policies and Epidemiology
Drug Solubulity and Delivery Systems
Global Health Care Issues
Nanoparticle-Based Drug Delivery
biodegradable polymer synthesis and properties
Adipokines, Inflammation, and Metabolic Diseases
Diet, Metabolism, and Disease
Metabolism, Diabetes, and Cancer
Estrogen and related hormone effects
Advanced Drug Delivery Systems
Adipose Tissue and Metabolism
Natural Antidiabetic Agents Studies
Nanoparticles: synthesis and applications
Drug-Induced Hepatotoxicity and Protection
Cardiovascular Health and Risk Factors
Advanced Glycation End Products research
Obesity, Physical Activity, Diet
Hydrogels: synthesis, properties, applications
Graphene and Nanomaterials Applications
Health disparities and outcomes
Endoplasmic Reticulum Stress and Disease
Pancreatic function and diabetes
Birth, Development, and Health

East Carolina University
2023-2025

Institute for Health Metrics and Evaluation
2023-2024

University of Washington
2023-2024

City, University of London
2024

Central Drug Research Institute
2015-2023

Academy of Scientific and Innovative Research
2019-2023

Shri Venkateshwara University
2019

Council of Scientific and Industrial Research
2016

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Kanyin Liane Ong Lauryn K Stafford Susan A. McLaughlin Edward J. Boyko Dan J. Stein and 95 more

Diabetes is one of the leading causes death and disability worldwide, affects people regardless country, age group, or sex. Using most recent evidentiary analytical framework from Global Burden Diseases, Injuries, Risk Factors Study (GBD), we produced location-specific, age-specific, sex-specific estimates diabetes prevalence burden 1990 to 2021, proportion type 1 2 in attributable selected risk factors, projections through 2050.

10.1016/s0140-6736(23)01301-6 article EN cc-by The Lancet 2023-06-23

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Mohsen Naghavi Kanyin Liane Ong Amirali Aali Hazim Ababneh Yohannes Habtegiorgis Abate and 95 more

<h2>Summary</h2><h3>Background</h3> Regular, detailed reporting on population health by underlying cause of death is fundamental for public decision making. Cause-specific estimates mortality and the subsequent effects life expectancy worldwide are valuable metrics to gauge progress in reducing rates. These particularly important following large-scale spikes, such as COVID-19 pandemic. When systematically analysed, rates allow comparisons consequences causes globally over time, providing a...

10.1016/s0140-6736(24)00367-2 article EN cc-by The Lancet 2024-04-03

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Michael Bräuer Gregory A. Roth Aleksandr Y. Aravkin Peng Zheng Kalkidan Hassen Abate and 95 more

<h2>Summary</h2><h3>Background</h3> Understanding the health consequences associated with exposure to risk factors is necessary inform public policy and practice. To systematically quantify contributions of factor exposures specific outcomes, Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021 aims provide comprehensive estimates levels, relative risks, attributable burden disease for 88 in 204 countries territories 811 subnational locations, from 1990 2021. <h3>Methods</h3> The...

10.1016/s0140-6736(24)00933-4 article EN cc-by The Lancet 2024-05-01

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Jaimie D Steinmetz Katrin Seeher Nicoline Schiess Emma Nichols Bochen Cao and 95 more

<h2>Summary</h2><h3>Background</h3> Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from Global Burden of Disease, Injuries, Risk Factor Study estimated burden 15 neurological conditions in 2015 2016, but these analyses did not defined by International Classification Diseases (ICD)-11, or a subset cases congenital,...

10.1016/s1474-4422(24)00038-3 article EN cc-by The Lancet Neurology 2024-03-14

Global Burden of Cardiovascular Diseases and Risks, 1990-2022

OPENALEX - Publications

George A. Mensah Valentı́n Fuster Christopher J L Murray Gregory A. Roth George A. Mensah and 95 more

10.1016/j.jacc.2023.11.007 article EN publisher-specific-oa Journal of the American College of Cardiology 2023-12-01

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

OPENALEX - Publications

Mohsen Naghavi Dan J. Stein Kevin S Ikuta Lucien R Swetschinski Authia P Gray and 95 more

10.1016/s0140-6736(24)01867-1 article EN cc-by The Lancet 2024-09-01

Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Austin E Schumacher Hmwe Hmwe Kyu Amirali Aali Cristiana Abbafati Jaffar Abbas and 95 more

10.1016/s0140-6736(24)00476-8 article EN The Lancet 2024-03-11

Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Dan J. Stein Hazim Ababneh Yohannes Habtegiorgis Abate Cristiana Abbafati Rouzbeh Abbasgholizadeh and 95 more

10.1016/s0140-6736(24)00685-8 article EN cc-by The Lancet 2024-05-01

Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Natalia V. Bhattacharjee Austin E Schumacher Amirali Aali Yohannes Habtegiorgis Abate Rouzbeh Abbasgholizadeh and 95 more

10.1016/s0140-6736(24)00550-6 article EN The Lancet 2024-03-21

Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Valery L. Feigin Melsew Dagne Abate Yohannes Habtegiorgis Abate Samar Abd ElHafeez Foad Abd-Allah and 95 more

10.1016/s1474-4422(24)00369-7 article EN cc-by The Lancet Neurology 2024-09-19

National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050

OPENALEX - Publications

Marie Ng Xiaochen Dai Rebecca M Cogen Michael Abdelmasseh Arash Abdollahi and 95 more

Over the past several decades, overweight and obesity epidemic in USA has resulted a significant health economic burden. Understanding current trends future trajectories at both national state levels is crucial for assessing success of existing interventions informing policy changes. We estimated prevalence from 1990 to 2021 with forecasts 2050 children adolescents (aged 5-24 years) adults ≥25 level. Additionally, we derived state-specific estimates projections older 15-24 all 50 states...

10.1016/s0140-6736(24)01548-4 article EN cc-by The Lancet 2024-11-01

Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

OPENALEX - Publications

Marie Ng Emmanuela Gakidou Justin Lo Yohannes Habtegiorgis Abate Cristiana Abbafati and 95 more

Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic crucial for providing an evidence base policy change. In this study, we examine historical trends global, regional, national prevalence adult overweight from 1990 to 2021 forecast 2050. Leveraging established methodology Global Burden Diseases, Injuries, Risk Factors Study, estimated among individuals aged 25 years older by age sex 204 countries territories Retrospective current were derived based on...

10.1016/s0140-6736(25)00355-1 article EN cc-by The Lancet 2025-03-01

Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021

OPENALEX - Publications

Jessica A. Kerr George Patton Karly Cini Yohannes Habtegiorgis Abate Nasir Abbas and 95 more

Despite the well documented consequences of obesity during childhood and adolescence future risks excess body mass on non-communicable diseases in adulthood, coordinated global action early life is still insufficient. Inconsistent measurement reporting are a barrier to specific targets, resource allocation, interventions. In this Article we report current estimates overweight across adolescence, progress over time, forecasts inform actions. Using established methodology from Global Burden...

10.1016/s0140-6736(25)00397-6 article EN cc-by The Lancet 2025-03-01

Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

OPENALEX - Publications

Nicholas Steel Clarissa Bauer‐Staeb John Ford Cristiana Abbafati Mohammed Abdalla and 95 more

Decades of steady improvements in life expectancy Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes risk factors and cause-specific death rates different European countries related those during pandemic. used data methods Global Burden Diseases, Injuries, Risk Factors Study 2021 compare at birth, causes death, population exposure 16 Economic Area (Austria, Belgium, Denmark, Finland, France, Germany,...

10.1016/s2468-2667(25)00009-x article EN cc-by The Lancet Public Health 2025-02-01

Formulation optimization of Docetaxel loaded self-emulsifying drug delivery system to enhance bioavailability and anti-tumor activity

OPENALEX - Publications

Guru R. Valicherla Kandarp M. Dave Syed Anees Ahmed Mohammed Riyazuddin Anand P. Gupta and 5 more

Abstract Poor bioavailability of Docetaxel (DCT) arising due to its low aqueous solubility and permeability limits clinical utility. The aim the present study was develop DCT loaded self-emulsified drug delivery systems (D-SEDDS) evaluate potential ability improve oral therapeutic efficacy DCT. D-SEDDS were characterized for their in vitro antitumor activity, situ single pass intestinal perfusion (SPIP), bioavailability, chylomicron flow blocking bio-distribution profile. prepared using...

10.1038/srep26895 article EN cc-by Scientific Reports 2016-05-31

Naringin ameliorates type 2 diabetes mellitus-induced steatohepatitis by inhibiting RAGE/NF-κB mediated mitochondrial apoptosis

OPENALEX - Publications

Syed Anees Ahmed Mohammad Irshad Reza Mohammad Shafiq Sanjana Kumariya Pragati Singh and 3 more

10.1016/j.lfs.2020.118118 article EN Life Sciences 2020-07-20

Global, regional, and national burden of pulmonary arterial hypertension, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Peter J. Leary Megan Lindstrom Catherine O. Johnson Sophia Emmons‐Bell Stuart Rich and 95 more

10.1016/s2213-2600(24)00295-9 article EN cc-by The Lancet Respiratory Medicine 2024-10-01

Burden of disease scenarios by state in the USA, 2022–50: a forecasting analysis for the Global Burden of Disease Study 2021

OPENALEX - Publications

Ali H. Mokdad Catherine Bisignano Johnathan M Hsu Dana Bryazka Shujin Cao and 95 more

10.1016/s0140-6736(24)02246-3 article EN The Lancet 2024-12-01

Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021

OPENALEX - Publications

Austin Carter Meixin Zhang Khai Hoan Tram Magdalene K. Walters Deepa Jahagirdar and 95 more

10.1016/s2352-3018(24)00212-1 article EN cc-by The Lancet HIV 2024-11-01

Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021

OPENALEX - Publications

Sarah Brooke Sirota Matthew C Doxey Regina-Mae Villanueva Dominguez Rose G Bender Avina Vongpradith and 95 more

10.1016/s1473-3099(24)00430-4 article EN cc-by The Lancet Infectious Diseases 2024-09-01

Hesperidin inhibits NOX4 mediated oxidative stress and inflammation by upregulating SIRT1 in experimental diabetic neuropathy

OPENALEX - Publications

Syed Anees Ahmed Mohammad Irshad Reza Himanshu Yadav Jiaur R. Gayen

Hesperidin possesses myriads of pharmacological benefits, including anti-inflammatory and antioxidant properties. Herein, we speculated that the described benefits hesperidin might be due to its potentiating action on SIRT1; thereby, inhibition NOX4. We developed diabetic neuropathy in Sprague-Dawley rats by feeding them a high-fat diet (HFD) for 12 weeks. checked effect level oxidative stress, inflammatory markers, NOX4, SIRT1 biochemical analysis, histopathology, immunoblotting,...

10.1016/j.exger.2022.112064 article EN cc-by Experimental Gerontology 2022-12-15

Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus

OPENALEX - Publications

Zakir Hossain Guru R. Valicherla Anand P. Gupta Syed Anees Ahmed Mohammed Riyazuddin and 3 more

Pancreastatin (PST) is an endogenous peptide which regulates glucose and lipid metabolism in liver adipose tissues. In type 2 diabetic patients, PST level high plays a crucial role the negative regulation of insulin sensitivity. Novel therapeutic agents are needed to treat diabetes resistance (IR) against action. this regard, we have investigated inhibitor peptide-8 (PSTi8) action diabetogenic PST. PSTi8 rescued PST-induced IR HepG2 3T3L1 cells. increases GLUT4 translocation cell surface...

10.1038/s41598-018-27018-8 article EN cc-by Scientific Reports 2018-06-01

Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice

OPENALEX - Publications

Anand P. Gupta Pragati Singh Richa Garg Guru R. Valicherla Mohammed Riyazuddin and 3 more

To investigate the role of pancreastatin inhibitor (PSTi8) in lipid homeostasis and insulin sensitivity dexamethasone induced fatty liver disease associated type 2 diabetes.Glucose releases assay, O staining ATP/AMP ratio were performed HepG2 cells. Twenty four mice randomly divided into 4 groups: Control group (saline), DEX (1 mg/kg, im) for 17 days, DEX+PSTi8 (acute 5 mg/kg chronic ip) 10 days. The glucose, pyruvate tolerance tests (GTT, ITT PTT), biochemical parameters Oxymax-CLAMS...

10.1016/j.biopha.2019.108959 article EN cc-by Biomedicine & Pharmacotherapy 2019-05-17

Coming Soon ...