A5073707664- Computational Drug Discovery Methods
- Research on Leishmaniasis Studies
- Synthesis and biological activity
- Trypanosoma species research and implications
- Biochemical and Molecular Research
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Enzyme Structure and Function
- Peptidase Inhibition and Analysis
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Biological Evaluation
- Malaria Research and Control
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Parasitic Diseases Research and Treatment
- Chemical Synthesis and Analysis
- Insect symbiosis and bacterial influences
- Drug Transport and Resistance Mechanisms
- Bone Metabolism and Diseases
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Antimicrobial Peptides and Activities
- Histone Deacetylase Inhibitors Research
Academy of Scientific and Innovative Research
2016-2025
Central Drug Research Institute
2016-2025
Université Moulay Ismail de Meknes
2022
Sidi Mohamed Ben Abdellah University
2022
Council of Scientific and Industrial Research
2011-2022
University of Hassan II Casablanca
2022
Institute of Structural and Molecular Biology
2015-2018
University of Lucknow
2015-2017
Oman Medical College
2017
AREA Science Park
2014
PknG is a Ser/thr protein kinase that plays crucial role in regulatory processes within the mycobacterial cell and signaling cascade of infected host cell. The essentiality virulence by blocking phagosome-lysosome fusion as well its intrinsic antibiotic resistance makes it an attractive drug target. However, only very few compounds have been reported Mycobacterium tuberculosis (MtPknG) inhibitors so far. Therefore, effort to find potential against MtPknG, we report here sequential...
Drug resistance to established antifungals such as azole derivatives (fluconazole and ketoconazole) is driving the rise in global mortality due fungal infection. Identification of new molecular entities structurally unrelated these may represent a valid strategy overcome currently available drugs. In an effort develop highly potent antifungal agents, we report herein series 27 compounds dithiocarbamate rhodanine molecules containing pyridine moiety their activity. Among synthesized...
Th1 immune responses play an important role in controlling Visceral Leishmaniasis (VL) hence, Leishmania proteins stimulating T-cell host, are thought to be good vaccine targets. Search of such antigens eliciting cellular Peripheral blood mononuclear cells (PBMCs) from cured/exposed/Leishmania patients and hamsters led the identification two enzymes glycolytic pathway soluble lysate a clinical isolate donovani - Enolase (LdEno) aldolase (LdAld) as potential stimulatory proteins. The present...
ABSTRACT The plastid of the malaria parasite, apicoplast, is essential for parasite survival. It houses several pathways bacterial origin that are considered attractive sites drug intervention. Among these sulfur mobilization (SUF) pathway Fe-S cluster biogenesis. Although SUF apicoplast maintenance and survival, there has been limited biochemical investigation its components inhibitors Plasmodium SUFs have not identified. We report characterization two proteins, falciparum SufS ( Pf SufS)...
Malaria is one of the major causes morbidity and mortality in developing countries especially Africa. Although over last fifteen years, prevalence malaria became reduced by half but resistance against artemisinin derivatives its combinations, which are only ray hope to treat resistant set back control efforts key hindrance achieve goal elimination till 2030. In spite these artemisinins precious antimalarials, their action mechanism yet be fully understood. Reactive oxygen species (ROS)...
The relict plastid (apicoplast) of the malaria parasite is site for important biochemical pathways and essential survival. sulfur mobilization ( SUF ) pathway iron–sulfur [Fe–S] cluster assembly in apicoplast Plasmodium spp. interest due to its absence human host suggesting possibility antimalarial intervention through biogenesis. We report characterization components falciparum after first step SUF. In vitro interaction experiments vivo cross‐linking showed that apicoplast‐encoded Pf SufB...
Human DNA ligases are enzymes that indispensable for replication and repair processes. Among the three human ligases, ligase I is attributed to ligation of thousands Okazaki fragments formed during lagging strand synthesis replication. Blocking therefore can lead accumulation single strands subsequently double breaks in DNA, which lethal cells. The reports high expression level protein several cancer cells (versus low rate division most normal adult body) support belief inhibitors target...
Pancreastatin (PST) is an endogenous peptide which regulates glucose and lipid metabolism in liver adipose tissues. In type 2 diabetic patients, PST level high plays a crucial role the negative regulation of insulin sensitivity. Novel therapeutic agents are needed to treat diabetes resistance (IR) against action. this regard, we have investigated inhibitor peptide-8 (PSTi8) action diabetogenic PST. PSTi8 rescued PST-induced IR HepG2 3T3L1 cells. increases GLUT4 translocation cell surface...
Analogues of a novel class hybrid 4-anilinoquinoline triazines have been synthesized with the aim identifying compounds improved antimalarial activity preserving potency parent drug chloroquine (CQ). All molecules were evaluated in vitro for their against chloroquine-sensitive 3D7 and chloroquine-resistant K1 strains P. falciparum. Molecules also screened cytotoxicity towards VERO cell line. Sixteen (17, 19, 26, 27, 29, 31, 32, 33, 35, 36, 37, 39, 40, 49, 50, 52) exhibited excellent IC50...
Fluconazole based novel mimics containing 1,5-disubstituted 1,2,3-triazoles were synthesized by using Ru catalysed 1,3 dipolar cycloaddition. All the newly compounds and pure enantiomers more potent than fluconazole against Candida albicans. Docking of 9A 9B showed different conformation in active site Cyp51 The 2 2A did not exhibit any toxicity up to 3.12 μg mL−1 mammalian cell line L929.