A5085229814- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Drug Delivery Systems
- Corneal Surgery and Treatments
- Synthesis and biological activity
- Research on Leishmaniasis Studies
- Glaucoma and retinal disorders
- Analytical Chemistry and Chromatography
- Bacterial Identification and Susceptibility Testing
- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Intraocular Surgery and Lenses
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Retinal Diseases and Treatments
- Ovarian function and disorders
- Trypanosoma species research and implications
- Pharmacological Effects and Toxicity Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Multicomponent Synthesis of Heterocycles
- Phytochemicals and Antioxidant Activities
- Hormonal and reproductive studies
Academy of Scientific and Innovative Research
2021-2025
Central Drug Research Institute
2020-2025
Council of Scientific and Industrial Research
2023
Dynamic emergence of microbial keratitis (MK) requires a promising therapeutic arsenal antifungal and antibacterial agents like voriconazole (VCZ) moxifloxacin (MOXI), respectively. Parallelly, another paradigm MK associated with ulcerative wounds cannot be left unnoticed antifibrotic remedy (pirfenidone, PIR) as an authalic antimicrobial to retain the primordial vision. For designing effective clinical cure, combination these three is required at dosage regimen. Following quest, we have...
Fenugreek seeds are used in numerous marketed herbal formulations with therapeutic benefits. Some of its bioactive components such as 4-hydroxyisoleucine, trigonelline, raffinose, and pinitol reported to possess potential activities, antibacterial, antidiabetic, stomach stimulant, anti-invasive, against hyperandrogenism other allied diseases, including polycystic ovary syndrome. A fully validated, selective, sensitive bioanalytical method for the simultaneous rapid quantification...
Purpose: Diabetic retinopathy (DR) is a microvascular retinal disease associated with chronic diabetes mellitus, characterized by the damage of blood vessels in eye. It projected to become leading cause blindness, given increasing burden diabetic population worldwide. The diagnosis and management DR pose significant challenges for physicians because involvement multiple biochemical pathways complexity ocular tissues. This review aims provide comprehensive understanding molecular implicated...
Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that prevalent in tropical countries, particularly developing regions of Asia and Africa. Factors like lens misuse, inappropriate steroid use, diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, deformities. Accurate pathological diagnosis crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves...
Aim: The fixed-dose combination of moxifloxacin (MOXI) and ketorolac tromethamine (KTR) is widely used for the treatment bacterial keratitis. Thus, a new LC–MS/MS method was developed to determine MOXI KTR in lacrimal fluid. Methods: Bioanalysis performed using Shimadzu 8050 electrospray ionization-positive mode validated per US FDA guidelines. Isocratic separation with Waters Symmetry C18 column methanol 0.1% formic acid containing deionized water (85:15, v/v). Results & conclusion: An...
Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and shown promise in eye care. This detailed review tracks evolution from treatment to aiding healing as evidenced by published literature. Pirfenidone's multifaceted attributes extend mitigating corneal inflammation, trauma. Through rigorous investigations, efficacy emerges diabetic retinopathy, macular degeneration, postoperative glaucoma interventions. As an unheralded protagonist, pirfenidone...
In the quest for discovery of antidiabetic compounds, a series 27 1,4-dihydropyridine–indole derivatives were synthesized using diversity approach. These compounds systematically evaluated their activity, starting with an in vitro assessment GLUT4 translocation stimulation L6-GLUT4myc myotubes, followed by vivo antihyperglycemic activity evaluation streptozotocin (STZ)-induced diabetic rat model. Among 12, 14, 15, 16, 19, 27, and 35 demonstrated significant potential to stimulate skeletal...
A novel, quick and precise RP-UHPLC analytical method for the simultaneous determination of moxifloxacin (MFX), voriconazole (VCZ) pirfenidone (PIR) was developed validated according to International Conference on Harmonization guidelines using a QbD-driven response surface Box-Behnken design. The considering selectivity, sensitivity, linearity, accuracy-precision, robustness, stability, limit detection quantification, respectively. Resolution between MFX, VCZ PIR achieved gradient elution...
Synthesis of a novel series 23 triazole–butenolide conjugates utilizing click chemistry and their antileishmanial, antimalarial, antifilarial activity along with SAR, ADME predictions pharmacokinetic study are discussed.
Anti-resorptive inhibitors such as bisphosphonates are widely used but they have limited efficacy and serious side effects. Though subcutaneous injection of teriparatide [PTH (1-34)] is an effective anabolic therapy, long-term repeated administration not recommended. Henceforth, orally bio-available small-molecule-based novel therapeutics unmet medical needs to improve the treatment. In this study, we designed, synthesized, carried out a biological evaluation 31 pyrimidine derivatives potent...
Abstract Managing ocular microbial infections typically requires pharmacotherapy using antibiotic eye drops, such as moxifloxacin hydrochloride (MFX), combined with an antifungal agent like amphotericin B (AB). We carried out and validated LC–MS/MS assay to quantify these compounds in rabbit tear fluid order look into the pharmacokinetics of two drugs. employed a protein precipitation technique for extraction drugs under examination. A Waters Symmetry C 18 column was used separate analytes...