A5090814314- Immune cells in cancer
- Phagocytosis and Immune Regulation
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Axon Guidance and Neuronal Signaling
- Metalloenzymes and iron-sulfur proteins
- Cancer, Lipids, and Metabolism
- Malaria Research and Control
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Apelin-related biomedical research
- Microscopic Colitis
- Advanced Neural Network Applications
- Cancer Cells and Metastasis
- Macrophage Migration Inhibitory Factor
- Cancer, Hypoxia, and Metabolism
- Vehicle License Plate Recognition
- Genetic factors in colorectal cancer
- Nuclear Receptors and Signaling
- Gastric Cancer Management and Outcomes
- Planarian Biology and Electrostimulation
- Cannabis and Cannabinoid Research
The Ohio State University
2019-2025
Sathyabama Institute of Science and Technology
2025
The Ohio State University Wexner Medical Center
2021-2023
Nationwide Children's Hospital
2019-2020
Central Drug Research Institute
2011-2017
Abstract Tumor-associated macrophages (TAM) are heterogeneous in nature and comprise antitumor M1-like (M1-TAM) or pro-tumor M2-like (M2-TAM) TAMs. M2-TAMs a major component of stroma breast tumors enhance metastasis by reducing their phagocytic ability increasing tumor fibrosis. However, the molecular mechanisms that regulate phenotypic plasticity TAMs not well known. Here we report novel suppressor Slit2 cancer regulating microenvironment. reduced vivo growth spontaneous syngeneic mammary...
Abstract Triple-negative breast cancer (TNBC), defined as loss of estrogen, progesterone, and Her2 receptors, is a subtype highly aggressive with worse prognosis poor survival rate. Macrophage migration inhibitory factor (MIF) pleiotropic pro-inflammatory cytokine aberrantly expressed in many solid tumors known to promote tumor progression metastasis. However, its role TNBC metastasis unexplored. Here we have shown that patients, MIF expression was significantly enriched the compared...
Chemotherapy forms the backbone of current treatments for many patients with advanced non-small-cell lung cancer (NSCLC). However, survival rate is low in these due to development drug resistance, including cisplatin resistance. In this study, we developed a novel strategy combat growth cisplatin-resistant (CR) NSCLC cells. We have shown that treatment plant-derived, non-psychotropic small molecular weight molecule, cannabidiol (CBD), significantly induced apoptosis CR addition, CBD reduced...
Molecular mechanisms underlying inflammation-associated breast tumor growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to enhance cancer and metastasis. However, the S100A7-mediated molecular in enhancing metastasis unclear.Human tissue plasma samples were used analyze expression of cPLA2, PGE2. S100A7-overexpressing or downregulated human metastatic cells evaluate downstream signaling mechanisms. Bi-transgenic mS100a7a15 overexpression, TNBC C3 (1)/Tag...
Ewing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents young adults. There unmet medical need to develop test novel pharmacological targets therapies treat EWS. Here, we found that EWS expresses high levels a p53 isoform, delta133p53. We further determined aberrant expression delta133p53 induced HGF secretion resulting growth metastasis. Thereafter, evaluated targeting tumors with receptor neutralizing antibody (AMG102) preclinical studies....
ABSTRACT The plastid of the malaria parasite, apicoplast, is essential for parasite survival. It houses several pathways bacterial origin that are considered attractive sites drug intervention. Among these sulfur mobilization (SUF) pathway Fe-S cluster biogenesis. Although SUF apicoplast maintenance and survival, there has been limited biochemical investigation its components inhibitors Plasmodium SUFs have not identified. We report characterization two proteins, falciparum SufS ( Pf SufS)...
The relict plastid (apicoplast) of the malaria parasite is site for important biochemical pathways and essential survival. sulfur mobilization ( SUF ) pathway iron–sulfur [Fe–S] cluster assembly in apicoplast Plasmodium spp. interest due to its absence human host suggesting possibility antimalarial intervention through biogenesis. We report characterization components falciparum after first step SUF. In vitro interaction experiments vivo cross‐linking showed that apicoplast‐encoded Pf SufB...
The pre-metastatic niche (PMN) represents an abnormal microenvironment devoid of cancer cells, but favoring tumor growth. Little is known about the mechanisms that generate PMN or their effects on host cells within metastasis-prone organs. Here, we investigated by using spontaneous metastatic models whether lung epithelial are essential for primary induced neutrophil recruitment in and subsequently initiating formation osteosarcoma. We found serum levels ANGPTL2 osteosarcoma patients...
Glioblastoma (GBM) remains one of the least successfully treated cancers. It is essential to understand basic biology this lethal disease and investigate novel pharmacological targets treat GBM. The aims study were determine biological consequences elevated expression ΔNp73, an N-terminal truncated isoform TP73, evaluate targeting its downstream mediators, angiopoietin 1 (ANGPT1)/tunica interna endothelial cell kinase 2 (Tie2) axis, by using a highly potent, orally available small-molecule...
Traffic sign detection and recognition (TSDR) are vital for autonomous driving advanced driver-assistance systems (ADAS), ensuring road safety efficient navigation. This project develops an effective TSDR system using Convolutional Neural Networks (CNNs) their superior image classification capabilities. The is trained on a dataset of traffic images, incorporating preprocessing techniques like grayscale conversion, histogram equalization, data normalization to enhance quality. Data...
Traffic sign detection and recognition (TSDR) are vital for autonomous driving advanced driver-assistance systems (ADAS), ensuring road safety efficient navigation. This project develops an effective TSDR system using Convolutional Neural Networks (CNNs) their superior image classification capabilities. The is trained on a dataset of traffic images, incorporating preprocessing techniques like grayscale conversion, histogram equalization, data normalization to enhance quality. Data...
The role of commensal bacterial microbiota in the pathogenesis human malignancies has been a research field incomparable progress recent years. Although breast tissue is commonly assumed to be sterile, studies suggest that may contain microbiota. In this study, we used an immune-competent orthotopic cancer mouse model explore existence unique and independent tumors. We observed some similarities with skin; however, tumor was mainly enriched Gram-negative bacteria, serving as primary source...
Small‐cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of with poor patient prognosis. However, the mechanisms that regulate SCLC progression and metastasis remain undefined. Here, we show expression slit guidance ligand 2 ( SLIT2 ) tumor suppressor gene reduced in tumors relative to adjacent normal tissue. In addition, receptor, roundabout receptor 1 ROBO1 ), upregulated. We find a positive association between Yes1 associated transcriptional regulator YAP1 )‐expressing...
Cancer-associated fibroblasts (CAFs) play an active role in remodeling the local tumor stroma to support initiation, growth, invasion, metastasis, and therapeutic resistance. The CAF-secreted chemokine, CXCL12, has been directly implicated tumorigenic progression of carcinomas, including breast cancer. Using a 3-D
The two organelles, apicoplast and mitochondrion, of the malaria parasite Plasmodium falciparum have unique morphology in liver blood stages; they undergo complex branching looping prior to division segregation into daughter merozoites. Little is known about molecular processes proteins involved organelle biogenesis parasite. We report identification an AAA+/FtsH protease homolog (PfFtsH1) that exhibits ATP- Zn2+-dependent activity. PfFtsH1 undergoes processing, forms oligomeric assemblies,...
Abstract Despite tremendous advances in oncology, metastatic triple-negative breast cancer remains difficult to treat and manage with established therapies. Here, we show mice orthotopic tumors that alternating (100 kHz), low intensity (<1 mV/cm) induced electric fields (iEFs) significantly reduced primary tumor growth distant lung metastases. Non-contact iEF treatment can be delivered safely non-invasively vivo via a hollow, rectangular solenoid coil. We discovered enhances anti-tumor...
Abstract Triple-negative breast cancer (TNBC) accounts for 15-20% of all cancers and lacks the expression estrogen, progesterone, Her2 receptors. TNBC is a highly aggressive subtype that has been associated with poorer prognosis worse overall survival rate. Macrophage migration inhibitory factor (MIF) multipotent pro-inflammatory cytokine, expressed in various reported to enhance tumor growth metastasis. However, its role influencing anti-tumor immunity unexplored. We have previously shown...