A5012744982- Heat shock proteins research
- Research on Leishmaniasis Studies
- Malaria Research and Control
- Synthesis and biological activity
- Trypanosoma species research and implications
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Toxin Mechanisms and Immunotoxins
- Synthesis and Biological Evaluation
- Endoplasmic Reticulum Stress and Disease
- Protein Structure and Dynamics
- Antifungal resistance and susceptibility
- Synthesis and Characterization of Heterocyclic Compounds
- SARS-CoV-2 and COVID-19 Research
- Chemical Synthesis and Analysis
- Parasitic Diseases Research and Treatment
- Vector-borne infectious diseases
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Insect symbiosis and bacterial influences
- Biochemical and Molecular Research
- Microtubule and mitosis dynamics
Guru Nanak Dev University
2017-2025
West Virginia University
2025
Rajendra Memorial Research Institute of Medical Sciences
2012-2024
Hebrew University of Jerusalem
2024
Homi Bhabha National Institute
2024
National Institute of Science Education and Research
2024
Jawaharlal Nehru University
2020-2024
National Institute of Immunology
2015-2023
Central Drug Research Institute
2012-2023
Indian Institute of Technology BHU
2023
Licochalcone A (I), isolated from the roots of Chinese licorice, is most promising antimalarial compound reported so far. In continuation our drug discovery program, we two similar chalcones, medicagenin (II) and munchiwarin (III), Crotalaria medicagenia , which exhibited activity against Plasmodium falciparum . library 88 chalcones were synthesized evaluated for their in vitro activity. Among these, 67, 68, 74, 77, 78 good P. strains 3D7 K1 with low cytotoxicity. These also showed reduction...
Breast cancer is one of the leading cause cancer-related deaths in women worldwide and increasing rapidly developing countries. In present study, we investigated potential role association HSP70-2 with breast cancer. expression was examined 154 tumor 103 adjacent non-cancerous tissue (ANCT) specimens cell lines (MCF7, BT-474, SK-BR-3 MDA-MB-231) by RT-PCR, quantitative-PCR, immunohistochemistry, Western blotting, flow cytometry indirect immunofluorescence. Plasmid driven short hairpin RNA...
Drug resistance to established antifungals such as azole derivatives (fluconazole and ketoconazole) is driving the rise in global mortality due fungal infection. Identification of new molecular entities structurally unrelated these may represent a valid strategy overcome currently available drugs. In an effort develop highly potent antifungal agents, we report herein series 27 compounds dithiocarbamate rhodanine molecules containing pyridine moiety their activity. Among synthesized...
Th1 immune responses play an important role in controlling Visceral Leishmaniasis (VL) hence, Leishmania proteins stimulating T-cell host, are thought to be good vaccine targets. Search of such antigens eliciting cellular Peripheral blood mononuclear cells (PBMCs) from cured/exposed/Leishmania patients and hamsters led the identification two enzymes glycolytic pathway soluble lysate a clinical isolate donovani - Enolase (LdEno) aldolase (LdAld) as potential stimulatory proteins. The present...
Abstract Lethality of Plasmodium falciparum caused malaria results from ‘cytoadherence’, which is mainly effected by exported erythrocyte membrane protein 1 (PfEMP1) family. Several P . proteins (exportome) including chaperones alongside cholesterol rich microdomains are crucial for PfEMP1 translocation to infected surface. An Hsp40 (heat shock 40) ‘PFA0660w’ functions as a co-chaperone ‘PfHsp70-x’, and these co-localize specialized intracellular mobile structures termed J-dots. Our studies...
Colorectal cancer (CRC) ranks third among the estimated cases and related mortalities in Western world. Early detection efficient therapy of CRC remains a major health challenge. Therefore, there is need to identify novel tumor markers for early diagnosis treatment CRC. A-kinase anchor protein 4 (AKAP4) gene expression was monitored by quantitative polymerase chain reaction (qPCR), reverse transcription (RT)-PCR blotting normal colon tissue lysate, epithelial cells cell lines viz., Caco-2,...
Fluconazole based novel mimics containing 1,5-disubstituted 1,2,3-triazoles were synthesized by using Ru catalysed 1,3 dipolar cycloaddition. All the newly compounds and pure enantiomers more potent than fluconazole against Candida albicans. Docking of 9A 9B showed different conformation in active site Cyp51 The 2 2A did not exhibit any toxicity up to 3.12 μg mL−1 mammalian cell line L929.
Abstract In the search for effective multifunctional agents treatment of Alzheimer’s disease (AD), a series novel hybrids incorporating benzofuran and chalcone fragments were designed synthesized. These screened by using transgenic Caenorhabditis elegans model that expresses human β‐amyloid (Aβ) peptide. Among investigated, ( E )‐3‐(7‐methyl‐2‐(4‐methylbenzoyl)benzofuran‐5‐yl)‐1‐phenylprop‐2‐en‐1‐one 4 f ), )‐3‐(2‐benzoyl‐7‐methylbenzofuran‐5‐yl)‐1‐phenylprop‐2‐en‐1‐one i...
Aging of organ and abnormal tissue regeneration are recurrent problems in physiological pathophysiological conditions. This is most crucial case high-turnover tissues, like bone marrow (BM). Using reciprocal transplantation experiments mouse, we have shown that self-renewal potential hematopoietic stem progenitor cells (HSPCs) BM cellularity markedly influenced with the age recipient mice rather than donor mice. Moreover, accumulation excessive reactive oxygen species (ROS) stromal compared...
<title>Abstract</title> Eukaryotic proteomes harbour repetitive stretches of amino acids that may play critical roles in the biology organism. While several tandem repeats (TR) are known to contribute protein structure and function, information about vast majority repeat regions remains obscure. In this article, we have analysed content different <italic>Plasmodium</italic>species found leading human malaria-causing <italic>P. falciparum</italic> (Pf) vivax</italic> be exceptionally rich TR...
ABSTRACT Eukaryotic proteomes harbour repetitive stretches of amino acids that may play critical roles in the biology organism. While several tandem repeats (TR) are known to contribute protein structure and function, information about vast majority repeat regions remains obscure. In this article, we have analysed content different Plasmodium species found leading human malaria-causing P. falciparum (Pf) vivax be exceptionally rich TR (>40% containing proteins). Detailed analysis Pf...
Abstract Cytoskeletal structures of Apicomplexan parasites are important for parasite replication, motility, invasion to the host cell and survival. Apicortin, an specific protein appears be a crucial factor in maintaining stability cytoskeletal assemblies. However, function apicortin, terms interaction with microtubules still remains elusive. Herein, we have attempted elucidate Plasmodium falciparum apicortin by monitoring its two main components microtubular structure, α-tubulin-I...
Fungal endocarditis (FE) is an uncommon and life-threatening disease with unacceptably high mortality rates. Only a handful of cases FE caused by Candida glabrata have been reported in the literature so far. We present case C. prosthetic valve (PVE) 59-year-old woman history aortic who was admitted after outpatient blood cultures came positive for yeast (later identified as glabrata). A trans-esophageal echocardiogram showed vegetation on valve. The patient successfully treated intravenous...