A5048343023- Immunotherapy and Immune Responses
- interferon and immune responses
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Neurogenesis and neuroplasticity mechanisms
- Virology and Viral Diseases
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Bacterial Infections and Vaccines
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Antimicrobial Peptides and Activities
- Hematopoietic Stem Cell Transplantation
- Viral Infections and Vectors
California NanoSystems Institute
2023
University of California, Los Angeles
2023
Institute of Biomedical Sciences, Academia Sinica
2017-2022
National Yang Ming Chiao Tung University
2020-2022
Institute of Molecular Biology, Academia Sinica
2020
National Institute of Immunology
2016
Many favorable anticancer treatments owe their success to the induction immunogenic cell death (ICD) in cancer cells, which results release of endogenous danger signals along with tumor antigens for effective priming immunity. We describe a strategy artificially induce ICD by delivering agonist stimulator interferon genes (STING) into cells using hollow polymeric nanoshells. Following intracellular delivery exogenous adjuvant, subsequent cytotoxic treatment creates cellular debris that...
Aging of organ and abnormal tissue regeneration are recurrent problems in physiological pathophysiological conditions. This is most crucial case high-turnover tissues, like bone marrow (BM). Using reciprocal transplantation experiments mouse, we have shown that self-renewal potential hematopoietic stem progenitor cells (HSPCs) BM cellularity markedly influenced with the age recipient mice rather than donor mice. Moreover, accumulation excessive reactive oxygen species (ROS) stromal compared...
The discovery of stimulator interferon genes (STING) and their agonists as primary components that link antiviral innate adaptive immunity has motivated growing research on STING agonist-mediated immunotherapy vaccine development. To overcome the delivery challenge in shuttling highly polar agonists, typically form cyclic dinucleotides, to target cells proteins cellular cytosol, numerous nanoformulation strategies have been implemented for effective activation. While many STING-activating...
Abstract The intricate functionalities of cellular membranes have inspired strategies for deriving and anchoring cell‐surface components onto solid substrates biological studies, biosensor applications, tissue engineering. However, introducing conformal right‐side‐out cell membrane coverage planar requires cumbersome protocols susceptible to significant device‐to‐device variability. Here, a facile approach biomembrane functionalization is demonstrated by subjecting confluent monolayer...
Despite the formidable treatment challenges of pancreatic ductal adenocarcinoma (PDAC), considerable progress has been made in improving drug delivery via pioneering nanocarriers. These innovations are geared towards overcoming obstacles presented by dysplastic stroma and fostering anti-PDAC immune reactions. We currently conducting research aimed at enhancing chemotherapy to stimulate anti-tumor immunity inducing immunogenic cell death (ICD). This is accomplished using lipid bilayer-coated...