A5043423755- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Colorectal Cancer Treatments and Studies
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Lymphoma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Pleural and Pulmonary Diseases
- Skin Diseases and Diabetes
- Autoimmune Bullous Skin Diseases
- CNS Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- HER2/EGFR in Cancer Research
Ospedale Santa Chiara
2016-2025
University of Trento
2023
Presidio Ospedaliero
2021
University of Verona
2011
University of Bologna
2001-2004
Policlinico S.Orsola-Malpighi
2004
The landscape of cancer treatment has undergone a significant transformation with the introduction Immune Checkpoint Inhibitors (ICIs). Patients undergoing these treatments often report prolonged clinical and radiological responses, albeit potential risk developing immune-related adverse events (irAEs). Here, we reviewed discussed mechanisms action ICIs their pivotal role in regulating immune system to enhance anti-tumor response. We scrutinized intricate pathogenic responsible for irAEs,...
Anti Jo-1 antibodies are the main markers of antisynthetase syndrome (ASSD), an autoimmune disease clinically characterized by occurrence arthritis, myositis, and interstitial lung (ILD). These manifestations usually co-occur (for practical purpose complete forms) in same patient, but cases with only 1 or 2 these findings incomplete have been described. In forms, ex novo further is possible, although frequencies timing not still defined. The aim this international, multicenter, retrospective...
Immune and vascular ageing are proposed risk factors for giant cell arteritis (GCA). Data on the impact of age at diagnosis GCA clinical presentation course disease scarce.Patients with followed referral centres within Italian Society Rheumatology Vasculitis Study Group were enrolled up to November 2021. Patients grouped according diagnosis: ≤64, 65-79 ≥80 years old.The study included 1004 patients, mean 72.1±8.4, female 70.82%. Median follow-up duration was 49 (IQR 23-91) months. in oldest...
The polymorphism 158V/F of Fc fragment IgG (FCGR) type 3A may influence the response to rituximab (RTX) in rheumatoid arthritis (RA). We investigated FCG3A a large cohort RA patients treated with RTX, also by considering possible loss from month +4 +6 after RTX and presence established predictors response.The study analysed 212 patients. European League Against Rheumatism (EULAR) was evaluated at months first infusion. FCGR3A PCR followed Sanger sequencing.The genotypes were associated EULAR...
This case report describes a 45-year-old woman who presented with painful oral erosions and chronic human leukocyte antigen B27–positive psoriatic peripheral arthritis associated recurrent anterior uveitis.
Anti-actin IgA antibodies have been found in sera of coeliacs. Our aim was to define the prevalence and clinical significance anti-actin coeliacs before after gluten withdrawal. One hundred two biopsy-proven coeliacs, 95 disease controls 50 blood donors were studied. evaluated by different methods: (a) antimicrofilament positivity on HEp-2 cells cultured fibroblasts immunofluorescence; (b) enzyme-linked immuosorbent assay (ELISA); (c) presence tubular/glomerular pattern anti-smooth muscle...
Summary Background : Anti‐ Saccharomyces cerevisiae and perinuclear anti‐neutrophil cytoplasmic autoantibodies are markers of Crohn's disease ulcerative colitis respectively. Aim To determine the prevalence anti‐ S. in a large series coeliac patients before after gluten free diet, to correlate ‐positivity with intestinal mucosal damage. Methods One hundred five consecutive 141 controls (22 colitis, 24 disease, 30 primary sclerosing cholangitis, 15 postenteritis syndrome, 50 blood donors)...
Introduction Combinations of immune checkpoint inhibitors (ICIs) and angiogenesis (AIs) have been investigated for the treatment several tumor types. Both ICIs AIs may lead to cardiovascular adverse events, their combination potentially increase risk toxicity. In present meta-analysis, we aim assess toxicity plus vs. alone. Secondary objectives are non-cardiovascular events efficacy. Methods Systematic review was performed according PRISMA statement. Phase II III randomized clinical trials...
To investigate the polymorphisms in promoter region of B lymphocyte stimulator (BLyS) gene as markers response to rituximab (RTX) rheumatoid arthritis (RA).The study was first conducted 152 Italian RA patients and then replicated an additional 117 (73 Italian, 44 British). The European League Against Rheumatism criteria were used evaluate rate at months 4 6 after cycle RTX, by means Disease Activity Score 28 joints using erythrocyte sedimentation rate; classified according best shown between...
This is an observational study of the mid-long-term results a single course phytothermotherapy with grass baths (group A, 54 patients), usual medical care B, 58 patients) and physiokinesistherapy (FKT, group C, 30 in knee osteoarthritis. For each consecutively treated patients we evaluated Lequesne algo-functional Index, drug consumption, frequency patient-physician contacts laboratory or radiological examinations after 10-15 days treatment at 3, 6, 9 12 months blind telephonic follow-up....
Abstract Objectives The primary objective of this study was the translation and validation ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire into Italian, denoted as AAV-PRO_ita. secondary to evaluate impact (AAV) on quality life (QoL) work impairment in a large cohort Italian patients. Methods design took prospective approach. First, AAV-PRO translated following step guidelines for translations. new AAV-PRO_ita covered three disease domains: organ-specific systemic...