A5075472187- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Case Reports on Hematomas
- Spondyloarthritis Studies and Treatments
- Liver Disease Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Diet, Metabolism, and Disease
- Bone and Joint Diseases
- Alcohol Consumption and Health Effects
- Alkaline Phosphatase Research Studies
- Pharmacological Effects of Natural Compounds
- Medicinal plant effects and applications
- Biomarkers in Disease Mechanisms
- Hepatitis C virus research
- Eosinophilic Disorders and Syndromes
- Osteomyelitis and Bone Disorders Research
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Inflammatory mediators and NSAID effects
- Bone health and treatments
- Musculoskeletal synovial abnormalities and treatments
- Systemic Lupus Erythematosus Research
- Biochemical and Molecular Research
- Adrenal Hormones and Disorders
VA Nasonova Scientific Research Institute of Rheumatology
2015-2024
Northern State Medical University
2021
Amsterdam Nursing Home
2019
Sechenov University
2019
University of Pennsylvania
2016
China Medical University
2015
University of Otago
2015
Radboud University Medical Center
2015
Assistance Publique – Hôpitaux de Paris
2015
Radboud University Nijmegen
2015
Создание руководства поддержано Советом по терапевтическим наукам отделения клинической медицины Российской академии наук.
Objective To determine which clinical, laboratory, and imaging features most accurately distinguished gout from non‐gout. Methods We performed a cross‐sectional study of consecutive rheumatology clinic patients with ≥1 swollen joint or subcutaneous tophus. Gout was defined by synovial fluid tophus aspirate microscopy certified examiners in all patients. The sample randomly divided into model development (two‐thirds) test (one‐third). Univariate multivariate association between clinical...
Objective To examine the performance of ultrasound (US) for diagnosis gout using presence monosodium urate monohydrate (MSU) crystals as gold standard. Methods We analyzed data from Study Updated Gout Classification Criteria (SUGAR), a large, multicenter observational cross‐sectional study consecutive subjects with at least 1 swollen joint who conceivably may have gout. All underwent arthrocentesis; cases were confirmed MSU crystals. Rheumatologists or radiologists blinded regard to results...
Clinical guidelines have long been one of the working tools modern doctor, helping him quickly navigate most effective proven methods treatment and prevention various diseases, also to adapt these specific tasks their patients achieve maximum personalization treatment. practice are drawn up by professional non-profit associations approved Scientific Council Ministry Health Russian Federation, while often recommendation is prepared two or even three associations. The peculiarity...
Objective To perform external validation of a provisional definition disease flare in patients with gout. Methods Five hundred nine gout were enrolled cross‐sectional study during routine clinical care visit at 17 international sites. Data collected to classify as experiencing or not flare, according definition. A local expert rheumatologist performed the final independent adjudication status. Sensitivity, specificity, predictive values, and receiver operating characteristic ( ROC ) curves...
According to the predominant mechanisms of immunity activation, human inflammatory diseases are divided into two main categories: autoimmune and autoinflammatory ones. At same time, have much common in both range clinical manifestations trigger environmental, epigenetic, genetic factors, mediators, tissue damage, approaches pharmacotherapy. The hyperproduction proinflammatory cytokine interleukin 1 (IL-1) is supposed largely determine cross between autoimmunity autoinflammation, which...
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To compare the sensitivity and specificity of different classification criteria for gout in early established disease.This was a cross-sectional study consecutive rheumatology clinic patients with joint swelling which defined by presence or absence monosodium urate crystals as observed certified examiner at presentation. Early disease patient-reported onset symptoms 2 years less.Data from 983 were collected present 509 (52%). 144 cases 228 non-cases. Sensitivity across better (95.3% vs...
Objective To identify the best‐performing survey definition of gout from items commonly available in epidemiologic studies. Methods Survey definitions were identified 34 studies contributing to Global Urate Genetics Consortium (GUGC) genome‐wide association study. Data Study for Updated Gout Classification Criteria (SUGAR) randomly divided into development and test data sets. A data‐driven case was formed using logistic regression set. This definition, along with used GUGC 2015 American...
Since the discovery in early 1960s by D.J. McCarty crystals of calcium pyrophosphate synovial fluid a patient with suspected gout, descriptions D. Zitnan and S. Sitaj radiological signs cartilage calcification, subsequent appearance terms “pseudogout” chondrocalcinosis, up to present time, issue standardization concepts related disease conditions symptoms has not been resolved. The various alternative names classification phenotypes considered article should be basis for creating unified...
Febuxostat (FS) is the drug of choice in impaired renal function, but dosage regimen and actual efficacy maximum allowable doses required to achieve target uric acid (UA) level patients with function have not been adequately studied. Objective: compare FS UA blood serum gout normal or near (glomerular filtration rate (GFR) >60 ml/min/1.73 m 2 ) moderately (GFR 30–60 function. Material methods. The study included 159 who were receiving urate-lowering medication had levels above 360 μmol/l....
Genetic polymorphisms in ABCG2 gene (V12M; rs2231137 and Q141K; rs2231142) patients with gout may determine the efficacy of colchicine for prevention arthritis attacks during initiation urate-lowering therapy. These data can be used development a personalized approach treatment gout. Objective: to evaluate different missense genetic variants rs2231142). Material methods. The study included 96 who were randomized into following groups: combined therapy (Colchicine LIRKA) 0.5 mg/day febuxostat...
The aim – to compare the efficacy and safety of different doses colchicine (0.5 mg/day vs 1.0 mg/day) used for prevention arthritis attacks in gout patients during initiation urate-lowering therapy. Materials methods. study included 96 diagnosed with gout. Patients were randomized into three groups: those receiving 0.5 mg/day, 1 without anti-inflammatory All participants prescribed febuxostat 80 mg/day. duration observation period was 6 months. frequency severity attacks, as well incidence...
Hyperuricemia is a condition characterized by an increase of serum uric acid level above 360 µmol/L. It known that high levels are not only the for etiopathogenesis gout but also important risk factor development and progression cardiovascular diseases, kidney liver pathologies, type 2 diabetes, others. This makes hyperuricemia relevant issue in general therapeutic practice. Despite extensive evidence on negative role many internal organ management strategy patients with asymptomatic real...
Objective. To determine the frequency of adverse events diagnostic arthrocentesis in patients with possible gout. Methods. Consecutive underwent and were evaluated at 6 weeks to events. The 95% CI obtained by bootstrapping. Results. Arthrocentesis was performed 910 patients, 887 (97.5%) for Any event observed 12 participants (1.4%, 0.6–2.1). There 1 case (0.1%, 0–0.34) septic arthritis. Conclusions. Diagnostic is associated a low Septic arthritis rarely occurs.
The 2018 national guidelines for the management of gout provide a consistent scheme urate-lowering drugs; however, possibility achieving uric acid (UA) targets in its use has not been studied. Objective : to evaluate effectiveness and safety therapy algorithm presented gout. Patients methods . This investigation was prospective single-center study. It currently included 54 patients (91% males) with follow-up period is less than 12 weeks continuous allopurinol or febuxostat (Azurix) at final...
Nowadays, there is increased interest in the connection of gout and asymptomatic hyperuricemia with comorbid conditions such as diabetes mellitus, cardiovascular diseases, hypertension, chronic kidney disease other. Studies conducted over past few decades suggest that not only gout, but also can significantly worsen prognosis patients deposition urate crystals be both an immediate cause a factor progression renal failure. In way, timely appointment - lowering therapy achieving target serum...
Diet has traditionally been viewed as playing a leading role in both the pathogenesis and treatment of gout. And although this thesis is controversial today, adherence to certain dietary rules for patients with gout hyperuricemia (HU) an integral part therapy. The review examines modern theoretical basis therapy HU, particular mechanisms increasing serum uric acid levels risk developing arthritis when foods are consumed and, conversely, reducing diet containing range vitamins supplements followed.
To estimate the time course of changes in clinical manifestations gout and their risk factors during a long-term follow-up.A total 160 male patients with were examined followed up for mean 6.9 ± 2.0 years. Their assessment included determination type arthritis over time, frequency attacks one year prior to examination, presence number subcutaneous tophi, inflamed joints, comorbid or co-occurring diseases (CD), allopurinol adherence, dietary compliance, taking non-steroidal anti-inflammatory...
In 2016, after 10 years since publication, the international guidelines of European Antirheumatic League (EULAR) for management gout were updated first time. The final version includes three overarching postulates and 11 key recommendations evaluating principles symptomatic therapy an acute attack arthritis and, more importantly, strategies urate-lowering therapy. aim above-mentioned is possibility their practical use. However, some statements, which contain controversial judgments, require...
To determine the relationship between gout flare rate and self-categorization into remission, low disease activity (LDA), patient acceptable symptom state (PASS).
The paper considers the new gout classification criteria approved by Board of Directors American College of Rheumatology (ACR) and Executive Committee European League Against Rheumatism (EULAR). The criteria have been elaborated on basis quantitative assessment data obtained during examinations of patients high sensitivity (92%) specificity (89%). These will be able to standardize an approach making up relatively homogeneous groups patients having clinical signs enrolled into investigation.
The community of many national and international recommendations dedicated to the treatment a specific disease, including gout, is fully justified, since it allows taking into account, for example, regional, ethnic characteristics manifestations which can be important when choosing therapy. However, this often associated with dissonance regarding solution key issues facing practitioner. publication in 2020 updated American College Rheumatology (ACR) guidelines management gout revealed...