A5038859956- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Inflammatory mediators and NSAID effects
- Spondyloarthritis Studies and Treatments
- Medicinal plant effects and applications
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Pregnancy and Medication Impact
- Bone and Joint Diseases
- Long-Term Effects of COVID-19
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- Medical and Biological Sciences
- Chronic Lymphocytic Leukemia Research
- Pregnancy-related medical research
- Adipose Tissue and Metabolism
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Atherosclerosis and Cardiovascular Diseases
- Myofascial pain diagnosis and treatment
- Body Contouring and Surgery
North-Western State Medical University named after I.I. Mechnikov
2015-2025
Ministry of Health of the Russian Federation
2017-2024
First Pavlov State Medical University of St. Petersburg
2007
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A meeting of the Expert Council on September 9, 2023 considered last challenges in treatment osteoarthritis (OA) including OA comorbid patients. Leading experts rheumatology, traumatology and other relevant disciplines participated meeting. The key goal was discussion potential application a combination undenatured (native) type II collagen, methylsulfonylmethane, boswellic acids, vitamins C D (Artneo complex) as part complex therapy. concluded that Artneo for stage I–III knee patients is...
Hyperuricemia is a condition characterized by an increase of serum uric acid level above 360 µmol/L. It known that high levels are not only the for etiopathogenesis gout but also important risk factor development and progression cardiovascular diseases, kidney liver pathologies, type 2 diabetes, others. This makes hyperuricemia relevant issue in general therapeutic practice. Despite extensive evidence on negative role many internal organ management strategy patients with asymptomatic real...
The European Society for Clinical and Economic Aspects of Osteoporosis Osteoarthritis (ESCEO) treatment algorithm the management knee osteoarthritis (OA), published in December 2014, provides practical guidance prioritization interventions. This current paper represents an assessment endorsement by Russian experts OA use clinical practice, with aim providing easy-to-follow advice on how to establish a flow patients OA, support clinicians’ individualized patient. Medications recommended ESCEO...
To enhance the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs), a class essential medications used to treat acute chronic pain, is an important urgent task. For its solution, in 2015 Russian experts provided an NSAID selection algorithm based on assessment risk factors (RFs) for drug-induced complications and on prescription with least negative effect gastrointestinal tract cardiovascular system. The PRINCIPLE project was implemented test effectiveness this algorithm....
Aim. To evaluate the effect of COVID-19 on clinical course immunoinflammatory rheumatic diseases (IRD). Material and methods . The IRD was analyzed in 324 patients who underwent new coronavirus infection (NCI) from March 2020 to February 2021 were treated at Clinical Rheumatology Hospital No. 25 (Saint-Petersburg, Russia) for exacerbation underlying disease. Results. risk factors severe were: age older than 60 years, presence comorbid conditions (IHD, CHD, COLD), use glucocorticoids dose more...
In recent decades, the prevalence of osteoarthritis (OA), one most disabling diseases, has increased worldwide, which imposes a significant burden on society. At international multidisciplinary meeting, experts various specialties (rheumatology, neurology, endocrinology, geriatrics, rehabilitation, traumatology and orthopedics) from Russia, Uzbekistan, Kazakhstan discussed importance an individualized approach to treatment patients with OA, taking into account comorbidities, identified...
The aim of the study – to evaluate effectiveness drug Alflutop (bioactive concentrate small marine fish), as well its effect on microcirculation parameters in patients with osteoarthritis (OA) joints hands. Patients and methods . included 80 aged 35 65 years OA hands, stage I– II according Kellgren Lawrence, pain ≥40 mm ≤90 a visual analogue scale (VAS). Subjects were distributed 1:1 ratio. In group (combined therapy) received standard scheme: 2 ml intramuscularly every other day N 10...
Relevance. Verification of a new coronavirus infection (COVID-19) requires clear algorithms for the diagnosis and treatment patients, depending on clinical, laboratory instrumental dates. Timely informed decisions optimizing management tactics prescribing proactive anti-inflammatory therapy before development complete symptom complex life threatening conditions are needed in some cases.
 Aim study. To analyze course outcomes infection, initial characteristics patients options.
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Background: Combined treatment with oral glucosamine hydrochloride (GH) and chondroitin sulfate (CS) was shown to be efficient for pain relief function improvement in osteoarthritis patients moderate severe knee [1,2]. Objectives: To investigate demographic clinical characteristics, changes pain, functions of daily living, quality life satisfaction (KOA) or hip (HOA) receiving long-term GH CS combination routine practice. Methods: An open-label, multicenter, observational prospective study...
Место тофацитиниба в стратегии лечения ревматоидного артритаМазуров В.И., Трофимов Е.А., Самигуллина Р.Р., Гайдукова И
Objective : to assess pain dynamics, daily functional activity of joints, quality life, and treatment satisfaction in patients with knee hip osteoarthritis (KOA HOA), who long take a combined glucosamine (GA) chondroitin sulfate (CS) drug routine clinical practice. Patients methods An interim analysis data from an open multicenter prospective non-interventional study that is being conducted the Russian Federation was carried out. The included Kellgren–Lawrence Stages I–III KOA or HOA, were...
There are few studies of the efficiency therapy with disease-modifying antirheumatic drugs (DMARDs) and biological agents (BAs) in patients early rheumatoid arthritis (eRA) as part a treat-to-target strategy. Objective : to investigate effects DMARDs BAs used combination methotrexate (MTX) on clinical course, quality life (QoL), evolution articular erosions synovitis RA. Patients methods . The investigation enrolled 151 eRA. At first stage, received DMARDs. second 101 persistent moderate...
The prevalence of systemic lupus erythematosus (SLE) varies greatly in different regions the world. disease is encountered age groups; however it most common young and adolescent women (its peak incidence range 15–25 years). Familial SLE cases are known. course pregnant noted to have features due an increased risk for complications pharmacotherapeutic peculiarities. Risk factors poor pregnancy outcomes, such as high activity at time conception, active nephritis, presence antiphospholipid...
Статья посвящена современным представлениям о лучевой диагностики остеоартроза с точки зрения врача-ревматолога.
It was revealed that in development of a coronary atherosclerosis, participate the immune-mediated mechanisms. In blood patients with atherosclerosis maintenance basic classes cytokines (IL-1 β, IL-2, IL-6, IL-8, TNF-a) were increased. Development acute insufficiency is accompanied by additional increase levels data cytokines. The accessory cytokine activity to confirmed at studying mRNA vascular wall. Thus zone atheromatous (aorta) it synthesized mainly while lipomatosis (a beam radial...
The review presents an analysis of the therapeutic effect in osteoarthritis (OA) original complex injectable drug Alflutop (bioactive concentrate small marine fish), which is one most widely used symptomatic slow acting drugs (SYSADOA) Russia. It stimulates proliferation chondrocytes, activates synthesis extracellular matrix by modulating transforming growth factor β (TGFβ), inhibits hyaluronidase, oxidative stress and activity expression proinflammatory cytokine genes – interleukin (IL) 1β,...
A patient with a subacute course of systemic sclerosis (SSc) and three-phase Raynaud's phenomenon at the onset disease is described. The diagnosis was made in accordance ACR/EULAR 2013 criteria. Within 8 months onset, developed classic picture SSc multiple organ involvement, nailfold capillaroscopy showed signs active stage scleroderma angiopathy. factors for an unfavorable were analyzed.
BACKGROUND: Knee osteoarthritis is a common degenerative disease characterized by cartilage destruction and inflammatory changes in the synovial membrane. Obesity metabolic syndrome are significant risk factors that exacerbate processes contribute to progression of osteoarthritis. Modern treatment methods include both pharmacological agents non-pharmacological approaches such as aerobic exercise. AIM: To evaluate compare effectiveness diacerein combined with physical activity (Nordic...
Patients suffering from rheumatic diseases are at high risk of the development and accelerated progression cardiovascular due to inflammation as one etiological factors atherogenesis heart failure. To choose rational safe treatment, especially in comorbid patients, it is necessary have a comprehensive complete understanding mechanisms these relationships, well most accurate determination using modern validated scales. The first part review presents results current experimental clinical...
Antiphospholipid antibodies (aPL): lupus anticoagulant (LA), anticardiolipin (aCL) and anti-β2-glycoprotein I (anti-β2GPI) are found in 12 to 44% of systemic erythematosus (SLE) patients. On average, antiphospholipid antibody syndrome (APS) develops in50% aPL-positive patients with SLE. The seronegative APS is characterized by the absence diagnostic levels "classical" aPL presence non-criteria aPL: against pro- thrombin (aPT), annexin V, phosphatidylethanoamine (aPE),...
Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which associated with psoriasis. The pathological process localized mainly in tissues locomotor system leads to development erosive intra-articular osteolysis. PsA occurs 5–7% patients moderate Despite advances treatment psoriasis diseasemodifying antirheumatic drugs (DMARDs) biological agents (BAs), problems immunogenicity, infectious complications, secondary inefficiency have not been fully...
The management of pregnant women with severe pain caused by primary or secondary osteoarthritis (OA) the hip joint (HJ) has not been developed. aim article was to evaluate influence NSAIDs, glucocorticoids (GC), analgesics and non-drug treatment methods on pregnancy outcomes in patients OA HJ.
 Methods. study included 99 aged 35 49 an intensive (≥4.0 points according visual analog scale (VAS)) due HJ. Depending form OA, severity patient’s opinion, following therapy adminestered:...