A5033174286- Drug Transport and Resistance Mechanisms
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Hemoglobinopathies and Related Disorders
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- Cancer therapeutics and mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics and Neurodevelopmental Disorders
- Glycosylation and Glycoproteins Research
- Pharmacological Effects and Toxicity Studies
- Thyroid Disorders and Treatments
- Renal and related cancers
- Carcinogens and Genotoxicity Assessment
- Ferroptosis and cancer prognosis
- Congenital heart defects research
- Sexual Differentiation and Disorders
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Iron Metabolism and Disorders
National Institute of Genetic Engineering and Biotechnology
2016-2025
Iran National Science Foundation
2020
Tehran University of Medical Sciences
2013
High Institute for Education and Research in Transfusion Medicine
2011-2012
Iranian Legal Medicine Organization
2006-2012
Zahedan University of Medical Sciences
2009
University of Tehran
2008
Commonwealth Scientific and Industrial Research Organisation
2005
One of the limitations in treatment cancer patients with chemotherapy is development multidrug resistance (MDR). A well-known mechanism responsible for drug over-expression ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports many hydrophobic substrates and anti-cancer drugs out cell. MDR1 polymorphisms could alter expression level P-gp consequently result resistance. We investigated possible association between C3435T...
Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer that notably associated with a high risk of lymph node metastasis, major cause mortality. Current therapeutic options remain limited to surgery supplemented by radio- or chemotherapy; however, these interventions often result in high-grade toxicities. Distant metastasis significantly contributed the poor prognosis decreased survival rates. However, underlying molecular mechanisms poorly understood. Disease-related "omics"...
A major problem in the treatment of breast cancer is development resistance to chemotherapeutic agents. Although role multidrug 1 (MDR1) and associated protein (MRP1) inducing drug many cancers has been widely investigated clinical significance expression these genes remains unclear data still controversial. We MDR1 MRP1 patients as well possible correlation between response chemotherapy. In present study, gene were by real time reverse transcription polymerase chain reaction (RT-PCR) assay...
A major problem in the treatment of breast cancer is development resistance to chemotherapeutic agents. Although role multidrug 1 (MDR1) and associated protein (MRP1) inducing drug many cancers has been widely investigated clinical significance expression these genes remains unclear data still controversial. We MDR1 MRP1 patients as well possible correlation between response chemotherapy. In present study, gene were by real time reverse transcription polymerase chain reaction (RT-PCR) assay...
Metastasis is known as a key step in cancer recurrence and could be stimulated by multiple factors. Calumenin (CALU) one of these factors which has direct impact on metastasis yet, its underlined mechanisms have not been completely elucidated. The current study was aimed to identify CALU co-expressed genes, their signaling pathways, expression status within the human cancers. To this point, associated genes were visualized using Cytoscape plugin BisoGenet annotated with Enrichr web-based...
Exposure to benzene would be associated with many diseases including leukemia. Epigenetic alterations seem among the main mechanisms involved.To determine if chronic occupational exposure low level of DNA methylation.Global methylation and promoter-specific two tumor suppressor genes, p14ARF p15INK4b, were assessed employing methylation-specific PCR using extracted from 40 petrochemical workers exposed ambient levels <1 ppm, 31 office not or its derivatives.While an increase in global 5%...
CONTEXT AND OBJECTIVE: Overexpression of the multidrug resistance-associated protein 1 (MRP1) gene has been linked with resistance to chemotherapy in vitro, but little is known about its clinical impact on acute leukemia patients. Our aim was investigate possible association between MRP1 expression level and outcomes among Iranian DESIGN SETTING: This an analytical cross-sectional study patients referred Hematology, Oncology Stem Cell Research Center, Sharyatee Public Hospital, whose...
Abstract Aim: Colorectal cancer is one of the most commonly diagnosed cancers in world. Cell adhesion molecules play an important role progression various cancers. It has been shown that high level expression some molecule could be a new diagnostic factor for several Vascular cell 1(VCAM1) surface glycoprotein expressed endothelium activated by cytokine. Generally, VCAM-1 very poor normal adult tissue endothelial cells. According to above explanation, this study was conducted investigate...
A small, mosaic, C-band negative marker chromosome was detected in amniocyte cultures during prenatal diagnosis due to advanced maternal age. Following spontaneous premature labor at 29 weeks gestation, a dysmorphic infant delivered, with flat nasal bridge, short palpebral fissures, micrognathia, high forehead, low-set ears, telecanthus and corneal dystrophy. Additional folds of skin were present behind the neck, feet, fingers toes abnormally long. The child died age five days, after two...
Multidrug resistance (MDR) is a main cause of failure in the chemotherapeutic treatment malignant disorders. One well-known genes responsible for drug encodes multidrug resistance- associated protein (MRP1). The association MRP1 with clinical has not systematically been investigated Iranian pediatric leukemia patients. We therefore applied real-time RT-PCR technology to study between gene and MDR phenotype found that overexpression occurred most patients at relapse. However, no relation mRNA...
H3.3 histone is a replacement subtype that express in entire cell cycle phases and overexpress transcriptionally active regions, promoter intergenic or intragenic regulatory elements. This encoded by two genes termed H3.3A (H3F3A) H3.3B (H3F3B). Mutations of these lead to some human cancers such as chondroblastoma, osteosarcoma, epithelial ovarian cancer. The aims this study were quantitatively examine the expression gene colorectal cancer (CRC) correlate their level with demographics...