A5084771303- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Forensic and Genetic Research
- Reproductive System and Pregnancy
- Genetic diversity and population structure
- Immunotherapy and Immune Responses
- interferon and immune responses
- Genomic variations and chromosomal abnormalities
- RNA and protein synthesis mechanisms
- Genetic Associations and Epidemiology
- Reproductive Physiology in Livestock
- Nutrition, Genetics, and Disease
- Immune Response and Inflammation
- Congenital Heart Disease Studies
- Congenital heart defects research
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Tracheal and airway disorders
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- High Altitude and Hypoxia
- HIV Research and Treatment
- Race, Genetics, and Society
- Zoonotic diseases and public health
- Cytokine Signaling Pathways and Interactions
University of Newcastle Australia
2025
Peking Union Medical College Hospital
2009-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Institute of Medical Biology
2023-2024
Kangbuk Samsung Hospital
2023
Sungkyunkwan University
2023
Academy of Medical Sciences
2002
Stanford University
2000
Fudan University
2000
University of Nottingham
2000
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across continent remains enigmatic. Here we report a large-scale survey autosomal from broad sample Asian human populations. Our results show that ancestry is strongly correlated with affiliations as well geography. Most populations relatedness within ethnic/linguistic groups, despite prevalent gene flow among More than 90% East (EA) haplotypes could be found in either Southeast...
Despite the fact that continuity of morphology fossil specimens modern humans found in China has repeatedly challenged Out-of-Africa hypothesis, Chinese populations are underrepresented genetic studies. Genetic profiles 28 sampled supported distinction between southern and northern populations, while latter biphyletic. Linguistic boundaries often transgressed across language families studied, reflecting substantial gene flow populations. Nevertheless, evidence does not support an independent...
Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to pangenome form, but populations of Asian ancestry are underrepresented. Here we present data the first phase Chinese Pangenome Consortium, including collection 116 high-quality and haplotype-phased de novo assemblies based on 58 core samples representing 36 minority ethnic groups. With average 30.65× high-fidelity long-read coverage, contiguity N50 more than 35.63 megabases total size 3.01 gigabases,...
The question surrounding the colonization of Polynesia has remained controversial. Two hypotheses, one postulating Taiwan as putative homeland and other asserting a Melanesian origin Polynesian people, have received considerable attention. In this work, we present haplotype data based on distribution 19 biallelic polymorphisms Y chromosome in sample 551 male individuals from 36 populations living Southeast Asia, Taiwan, Micronesia, Melanesia, Polynesia. Surprisingly, nearly none Taiwanese...
In this study, polymorphisms of human leukocyte antigen (HLA) class I (A, B, and Cw) II (DRB1) loci were analyzed in an isolated Han population living Fengyandong the Yunnan province Southwest China (FYDH) using a high-resolution polymerase chain reaction-Luminex typing method. A total 13 A, 26 15 Cw, 23 DRB1 alleles HLA found FYDH. The frequencies A*1101, A*0207, A*2402, B*4601, B*1502, Cw*0102, Cw*0801, DRB1*0901, DRB1*1202 >10%. following haplotypes common with >5%: three A-B, four Cw-B,...
Abstract The frequencies of the human leukocyte antigen alleles HLA‐A, HLA‐B, and HLA‐DRB1 A‐B‐DRB1, A‐B, B‐DRB1 haplotypes were studied in Naxi Yunnan Han populations using polymerase chain reaction (PCR)‐sequence‐specific amplification for A B a PCR‐microtiter plate hybridization method DRB1 allele. total 8 A, 19 B, 30 found population, 15 21 36 population. common A‐B‐DRB1 population A*24‐B*15‐DRB1*1202, A*11‐B*15‐DRB1*0405, A*11‐B*15‐DRB1*1202, A*11‐B*38‐DRB1*08032, A*11‐B*55‐DRB1*0405;...
Tai people are widely distributed in Thailand, Laos and southwestern China a large population of Southeast Asia. Although most anthropologists historians agree that modern from northern the place which they historically migrated remains controversial. Three popular hypotheses have been proposed: origin hypothesis, southern hypothesis or an indigenous origin. We compared genetic relationships between their "siblings" to test different by analyzing 10 autosomal microsatellites. The data 916...
Male infertility is a multifactorial syndrome encompassing wide variety of disorders. In recent years, several genome-wide single-nucleotide polymorphism (SNP) association studies (GWAS) have been performed on azoospermia and/or oligozoospermia in different populations including two GWAS nonobstructive China; however, the SNPs with idiopathic male infertility, especially asthenozoospermia and oligozoospermia, their correlation semen parameters are still not clear. To investigate genetic...
We examined human leucocyte antigen (HLA) gene polymorphisms in the Maonan people from southern China. HLA-A, -B and -DRB1 alleles were determined 108 healthy unrelated individuals by polymerase chain reaction-Luminex method, haplotype frequencies for loci estimated. The most frequent HLA-A A*1101 (35.2%), A*0203 (17.6%), A*0207 (13.4%) A*2402 (13.4%); HLA-B B*1301(19.9%), B*1502 (14.8%), B*4601 B*4001 HLA-DRB1 DRB1*1202 (17.1%), DRB1*1602 (13.0%) DRB1*1401 (10.7%). common haplotypes...
Summary Human leucocyte antigen (HLA) genetic characteristic of different ethnic minorities would be useful for tracing the origin modern human HLA matching in transplantation and disease associations. In this study, we reported HLA‐A, ‐B, ‐C ‐DRB1 alleles haplotypes Bulang Hani populations southwestern China using a high‐resolution polymerase chain reaction‐Luminex (PCR‐Luminex) typing method. A total nine 22 HLA‐B, 13 HLA‐C 18 HLA‐DRB1 were identified population, 11 25 14 19 population....
Abstract Distinct human leukocyte antigen ( HLA ) allele and haplotype distributions occur in the northern southern Han populations of China. However, different ethnic groups China show limited regional for many alleles haplotypes. Therefore, it is necessary meaningful to study differences distribution A total 428 unrelated individuals from Lisu, Nu, Tu Yugur were genotyped ‐A, ‐B, ‐C ‐ DRB1 using PCR ‐Luminex typing method. The frequencies statistically inferred haplotypes calculated. 29 54...
Abstract Background Atrial septal defect (ASD) is a common form of congenital heart disease. Although several genes related to ASD have been found, the genetic factors remain unclear. This study aimed evaluate correlation between 10 candidate single nucleotide polymorphisms (SNPs) and sporadic atrial defects. Methods Based on results 34 individual whole exome sequences, SNPs were selected. In total, 489 samples 420 normal collected. The in case group control identified through Snapshot...
Human leukocyte antigen (HLA) analysis would be a useful tool to trace the origin of modern humans. In this study, we provided first four digital HLA-A, -B, -C and -DRB1 allele haplotype data in Dai ethnic population, which is unique representative Kam-Tai-speaking minority living Yunnan province Southwestern China. Our results showed that population has HLA characteristic are most closely related Southeastern Asia group similar Kam-Tai speaking populations China Thailand.
Population migrations in Southwest and South China have played an important role the formation of East Asian populations led to a high degree cultural diversity among ethnic minorities living these areas. To explore genetic relationships minorities, we systematically surveyed variation 10 autosomal STR markers 1,538 individuals from 30 25 which majority were chosen China, especially Yunnan Province. With genotyped data markers, constructed phylogenies with both DA DC measures performed...
To assess the association between genetic polymorphisms of 7 SNPs in PTPN22 and PADI4 genes susceptibility to rheumatoid arthritis Yunnan.A case-control study was carried out on 192 patients 288 healthy controls. Genotypes rs33996649 1858 loci within gene, rs11203366 rs874881 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. rs1635579, rs2428736 rs2240340 pyrosequencing.The frequencies alleles genotypes locus showed a significant...