Ranjan Deka
A5047807086- Genetic Associations and Epidemiology
- Forensic and Genetic Research
- Genetic diversity and population structure
- Nutrition, Genetics, and Disease
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Race, Genetics, and Society
- Obesity, Physical Activity, Diet
- Genetic Neurodegenerative Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA modifications and cancer
- Hemoglobinopathies and Related Disorders
- Forensic Anthropology and Bioarchaeology Studies
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Molecular Biology Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Moyamoya disease diagnosis and treatment
- Genomics and Rare Diseases
- Nutritional Studies and Diet
- Telomeres, Telomerase, and Senescence
- Adipose Tissue and Metabolism
- Prostate Cancer Treatment and Research
University of Cincinnati
2015-2025
University of Cincinnati Medical Center
2014-2023
Beth Israel Deaconess Medical Center
2014-2021
University of California, San Diego
2019
Broad Institute
2013-2015
Quinnipiac University
2015
Michigan Medicine
2014-2015
Harborview Medical Center
2014-2015
University of Washington
2014-2015
University of Virginia Health System
2014-2015
SummaryWe analyzed the European genetic contribution to 10 populations of African descent in United States (Maywood, Illinois; Detroit; New York; Philadelphia; Pittsburgh; Baltimore; Charleston, South Carolina; Orleans; and Houston) Jamaica, using nine autosomal DNA markers. These markers either are population-specific or show frequency differences >45% between parental thus especially informative for admixture. ancestry ranged from 6.8% (Jamaica) 22.5% (New Orleans). The unique utility...
Using the generalized stepwise mutation model, we propose a method of estimating relative rates microsatellite loci, grouped by repeat motif. Applying ANOVA to distributions allele sizes at loci from set populations, motif types, estimated effect population size differences and rate among loci. This provides an estimate motif-type-specific up multiplicative constant. Applications four different sets di-, tri-, tetranucleotide number human populations reveal that, on average,...
Background and Purpose — Intracerebral hemorrhage (ICH) has a 30-day mortality rate of 40% to 50% lacks proven treatment. We report preplanned, midpoint analysis the first population-based, case-control study that examines both genetic environmental risk factors ICH. Methods prospectively identified cases hemorrhagic stroke at all 16 hospitals in Greater Cincinnati/Northern Kentucky region. All underwent medical record neuroimaging review. Cases enrolled direct interview sampling arm were...
Genetic distance measures are indicators of relatedness among populations or species and useful for reconstructing the historic phylogenetic relationships such groups. Classical genetic were developed to analyze biochemical serological polymorphisms, systems which generally show limited variability. However, these traditional inadequate analysis certain classes variable number tandem repeat (VNTR) loci, have a larger alleles higher levels heterozygosity than markers. At observed at standard...
Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood. Genomewide association studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has explored. In this study, we report use whole exome sequencing (WES) seven densely-affected families (45 individuals) recruited as part Familial Intracranial Aneurysm study. WES variants were prioritized by functional prediction, frequency, predicted pathogenicity, and...
Risk factors have been described for spontaneous intracerebral hemorrhage (ICH); their relative contribution to lobar vs nonlobar location is less clear. Our purpose here was investigate risk by location.This case-control study prospectively enrolled subjects with first-ever ICH and matched each up 3 controls age, race, gender. Conditional stepwise logistic regression modeling used determine significant independent ICH.From December 1997 through 2006, 597 cases 1,548 qualified the analysis....
Background— Genomewide association studies have identified novel genetic factors that contribute to intracranial aneurysm (IA) susceptibility. We sought confirm previously reported loci, identify risk factors, and evaluate the contribution of these familial sporadic IA. Method— utilized 2 complementary samples, one recruited on basis a dense family history IA (discovery sample 1: 388 cases 397 controls) other without regard 2: 1095 1286 controls). Imputation was used generate common set...
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy CAD. TERT (which encodes telomerase reverse transcriptase) is the most significantly associated germline locus CHIP in...
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWASs leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study across ancestrally diverse individuals (European, African, Asian, Hispanic/Latino) from NHLBI Trans-Omics Precision Medicine (TOPMed) program. We used whole-genome sequencing (WGS) of whole blood variant genotype calling bioinformatic estimation in n = 109,122...
Globally, autosomal recessive IFNAR1 deficiency is a rare inborn error of immunity underlying susceptibility to live attenuated vaccine and wild-type viruses. We report seven children from five unrelated kindreds western Polynesian ancestry who suffered severe viral diseases. All the patients are homozygous for same nonsense variant (p.Glu386*). This allele encodes truncated protein that absent cell surface loss-of-function. The fibroblasts do not respond type I IFNs (IFN-α2, IFN-ω, or...
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide study (GWAS) summary statistics, whole-genome sequences expression quantitative trait locus (eQTL) data from diverse ancestries. We developed a new approach, TESLA (multi-ancestry integrative using an optimal linear combination of statistics), to integrate eQTL dataset with multi-ancestry GWAS. By exploiting shared phenotypic effects...
The question surrounding the colonization of Polynesia has remained controversial. Two hypotheses, one postulating Taiwan as putative homeland and other asserting a Melanesian origin Polynesian people, have received considerable attention. In this work, we present haplotype data based on distribution 19 biallelic polymorphisms Y chromosome in sample 551 male individuals from 36 populations living Southeast Asia, Taiwan, Micronesia, Melanesia, Polynesia. Surprisingly, nearly none Taiwanese...
Austronesian is a linguistic family spread in most areas of the Southeast Asia, Pacific Ocean, and Indian Ocean. Based on their similarity, this included Malayo-Polynesians Taiwan aborigines. The similarity also led to controversial hypothesis that homeland all Malayo-Polynesians, has been debated by ethnologists, linguists, archaeologists, geneticists. It well accepted Eastern Austronesians (Micronesians Polynesians) derived from Western (Island Asians Taiwanese), Daic populations mainland...
Abstract The role of adaptive immunity in the development or progression chronic obstructive pulmonary disease (COPD) remains undefined. Recently, presence autoantibodies and autoreactive T cells has been demonstrated COPD patients. In addition, oligoclonal expansions lung have observed patients, but overlapping incidence infections, tumors, cigarette smoke exposure obscures antigenic stimulus. We analyzed TCR Vβ repertoire CD4 CD8 purified from lungs spleens mice chronically exposed to...