A5054266211- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Rate Variability and Autonomic Control
- Chronic Kidney Disease and Diabetes
- Cardiovascular Syncope and Autonomic Disorders
- Clinical practice guidelines implementation
- Chromium effects and bioremediation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Disease Prevention
- Advanced Glycation End Products research
- Cancer Risks and Factors
- Cardiac Health and Mental Health
- Cardiovascular Function and Risk Factors
- Natural Antidiabetic Agents Studies
- Heart Failure Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
GGZ Drenthe
2019-2024
University Medical Center Groningen
2013-2022
University of Groningen
2013-2022
Isala
2008-2018
Dialyse Centrum Groningen
2014
Diabetes UK
2008-2014
Reformed University of Applied Sciences
2010-2014
Leiden University Medical Center
2014
Clinica Santa Maria
2013
Linköping University
2013
Several studies have suggested an association between specific diabetes treatment and cancer mortality. We studied the metformin use mortality in a prospectively followed cohort.In 1998 1999, 1,353 patients with type 2 were enrolled Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) study Netherlands. Vital status was assessed January 2009. Cancer rate evaluated using standardized ratios (SMRs), Cox proportional hazards model, taking possible confounders into...
Progressive CKD is generally detected at a late stage by sustained decline in eGFR and/or the presence of significant albuminuria. With aim early and improved risk stratification patients with CKD, we studied urinary peptides large cross-sectional multicenter cohort 1990 individuals, including 522 follow-up data, using proteome analysis. We validated that previously established multipeptide biomarker classifier performed significantly better detecting predicting progression than current...
OBJECTIVE—Skin autofluorescence is a noninvasive measure of the level tissue accumulation advanced glycation end products, representing cumulative glycemic and oxidative stress. Recent studies have already shown relationship between skin diabetes complications, as well predictive value for total cardiovascular mortality in type 2 diabetes. Our aim was to investigate development microvascular complications RESEARCH DESIGN AND METHODS—At baseline, 973 diabetic patients with well-controlled...
Objective . We performed a systematic review of the literature to evaluate effects alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes mellitus. Research design and methods The databases MEDLINE EMBASE were searched using key words “lipoic acid’’, “thioctic “diabet*’’, MeSH-terms acid’’ “diabetes mellitus’’. Randomised controlled trials TSS score as outcome measure selected assessed their methodological quality. Study selection quality assessment independently...
We aimed to assess and characterize sex differences in adverse drug reactions (ADRs) reported the national pharmacovigilance centre Netherlands while considering use.ADRs spontaneously by healthcare professionals patients Lareb were used. Drug-ADR combinations at least 10 times between 2003-2016 for drugs used ≥10,000 persons that period included. Data about number of users was obtained from National Health Care Institute. Sex-specific ADRs, like gynaecological problems, excluded. Sex...
OBJECTIVE—Chromium treatment has been reported to improve glycemic control and insulin sensitivity in specific populations of patients with type 2 diabetes. The aim this study was determine the effect chromium on a Western population insulin-dependent RESEARCH DESIGN AND METHODS—In 6-month double-blind study, an HbA1c (A1C) >8% requirements >50 units/day were randomly assigned receive placebo or 500 1,000 μg daily form picolinate. primary efficacy parameter change A1C....
OBJECTIVE—To investigate the relationship between health-related quality of life (HRQOL) and mortality in type 2 diabetes. RESEARCH DESIGN AND METHODS—In 1998, 1,143 primary care patients with diabetes participated Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) study. At baseline, HRQOL was assessed RAND-36 and, after almost 6 years, status retrieved. Cox proportional hazards modeling used to association (continuous data) adjustment for selected confounders (smoking,...
OBJECTIVE To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes nephropathy. RESEARCH DESIGN AND METHODS Patients UAE equivalent to 15–300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned 12 weeks (900 mg/day) (n = 39) placebo 43). RESULTS Compared placebo, treatment resulted significant improvement thiamine status (P...
OBJECTIVE Diabetes negatively impacts the health-related quality of life (HRQOL) patients with type 2 diabetes. An earlier analysis showed HRQOL to be associated mortality, which suggests that measuring could have clinical implications. We studied association between and total cardiovascular mortality in diabetes during long-term follow-up specifically focused on old age sex differences. RESEARCH DESIGN AND METHODS was measured a prospectively followed cohort 1,353 using RAND-36. Cox...
Self-monitoring of blood glucose (SMBG), including self-regulation, is an important tool to achieve good glycemic control. However, many patients measure their concentrations less often than recommended. This study investigates patients' perspectives SMBG and all relevant aspects influencing in with type 1 insulin-treated 2 diabetes.In depth interviews were conducted 13 diabetes from outpatient clinic 15 general practices. All transcribed verbatim analyzed using the Grounded Theory...
Advanced glycation end products play a pivotal role in atherosclerosis. Recently, we showed that tissue advanced deposition, noninvasively assessed by skin autofluorescence (SAF), is increased patients with peripheral artery disease. The aim of the present study was to establish whether SAF associated all-cause mortality and fatal or nonfatal major adverse cardiovascular events (MACE) disease.We performed single-center prospective cohort 252 disease (mean age, 66±11 years), recruited from...
To determine whether the management of type 2 diabetes mellitus in a primary care setting can be safely transferred to practice nurses.Because increasing prevalence and burden caring for individual patients, demand patients place on health resources has become overwhelming.Randomised controlled trial.The intervention group were cared by nurses who treated glucose levels, blood pressure lipid profile according specified protocol. The control received conventional from general practitioner....
Non-equivalence in serum creatinine (SCr) measurements across Dutch laboratories and the consequences hereof on chronic kidney disease (CKD) staging were examined. National data from annual external quality organization of 2009 used. 144 participating examined 11 pairs commutable, value-assigned SCr specimens range 52–262 μmol/L, using Jaffe or enzymatic techniques. Regression equations created for each laboratory (by regressing values as measured by target samples sent organization); area...
Background: The combination of an increasing prevalence diabetes mellitus and more people having access to smartphones creates opportunities for patient care. This study aims investigate whether the use Diabetes Under Control (DBEES) mobile phone application, a digital diary, results in change quality life patients with type 1 (T1DM) compared standard paper diary. Methods: In this randomized controlled open-label trial, 63 T1DM smartphone were assigned intervention group using DBEES...
Chromium treatment has been reported to improve glycemic control in patients with type 2 diabetes. However, concern exists about the possible toxic effects of chromium picolinate. The aim this study was determine effect form yeast on a Western population diabetes who were being treated oral hypoglycemic agents.In 6-month, double-blind study, moderate control, agents, randomly assigned receive either placebo or 400 microg daily yeast. primary efficacy parameter change A1C. Secondary end...
There is no general agreement regarding the use of first or second drop blood for glucose monitoring. This study investigated whether capillary concentrations, as measured in and drops blood, differed ≥ 10% compared with a control concentration different situations.Capillary concentrations were two consecutive following circumstances 123 patients diabetes: without washing hands, after exposing hands to fruit, fruit-exposed during application amounts external pressure around finger. The...
Although orthostatic hypotension (OH) is more prevalent in old age, and patients with diabetes, the prevalence of OH older type 2 diabetes mellitus unknown.To establish OH, its association falling, home-dwelling participants without diabetes.A cross-sectional study primary care Netherlands.A total 352 211 participated this study. was defined as a fall blood pressure at least 20 mmHg systolic or 10 diastolic after either 1 3 minutes an upright position. Feelings dizziness, light-headedness,...
OBJECTIVE Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump has been available for the past 25 years. CIPII, its specific pharmacodynamic properties, may be a viable treatment alternative to improve glycemic control in patients type 1 diabetes whom other therapies have failed. There few studies which CIPII was compared subcutaneous poor control. RESEARCH DESIGN AND METHODS In open-label, prospective, crossover, randomized, 16-month study, effects of and were 24...
to investigate the relationship between blood pressure over time and mortality in elderly patients with type 2 diabetes mellitus (T2DM).prospective observational cohort study.primary care, Zwolle, The Netherlands.patients T2DM aged 60 years older (n = 881). was divided into two age categories: 60-75 than 75 years.updated means for systolic, diastolic pulse pressures were calculated after a median follow-up of 9.8 years. These values used as time-dependent covariates Cox proportional hazard...