A5061223187- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Antioxidant Activity and Oxidative Stress
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Ocular and Laser Science Research
- Corneal surgery and disorders
- Cerebral Venous Sinus Thrombosis
- Ocular Surface and Contact Lens
- Ocular Oncology and Treatments
- Vascular Malformations Diagnosis and Treatment
- Advanced Glycation End Products research
- Ocular Infections and Treatments
- Retinoids in leukemia and cellular processes
- Ocular Disorders and Treatments
- Neuroscience and Neural Engineering
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Retinopathy of Prematurity Studies
- Connexins and lens biology
Université de Bordeaux
2016-2025
Centre Hospitalier Universitaire de Bordeaux
2016-2025
Inserm
2016-2025
Bordeaux Population Health
2016-2025
French Clinical Research Infrastructure Network
2024-2025
Hôpital Pellegrin
2012-2024
Université de Montpellier
2023
Centre National de la Recherche Scientifique
2011-2017
Sorbonne Université
2004-2017
Institut de la Vision
2011-2017
To report cases of intraocular inflammation after intracameral injection a very high dose cefuroxime at the end uneventful cataract surgery.Department Ophthalmology, Bordeaux University Hospital, Bordeaux, France.Case series.Patients were followed on an outpatient basis and examined postoperatively 1 5 days 6 weeks. Central macular thickness, angiography, central corneal thickness (CCT), endothelial cell density (ECD), electroretinography (ERG) analyzed to evaluate ocular toxicity.One day...
Background Lipid metabolism and particularly high-density lipoprotein (HDL) may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported associations AMD with plasma HDL other lipids, which confounded by recently HDL-related genes. We explored association lipid levels lipid-lowering medication use, taking into account most genes associated AMD. Methods The Alienor study is a population-based on eye diseases performed...
Abstract. Purpose: To describe dry eye disease in French elderly subjects. Methods: The Alienor Study is a population‐based study on age‐related 963 residents of Bordeaux (France), aged 73 years or more. Self‐reported and use artificial tears were documented through face‐to‐face interview. Dry symptoms assessed using the Ocular Surface Disease Index (OSDI) questionnaire tear film stability by break‐up time measurements (TBUT). Definite was defined as self‐reported eye, confirmed and/or OSDI...
Worldwide, degenerative eye diseases (age-related maculopathy (ARM), cataract, glaucoma) are the main causes of visual impairment and blindness, which contribute to disability in elderly. Mainly three types nutritional factors investigated for their potential protection against ageing: antioxidants; lutein zeaxanthin (carotenoids accumulate specifically eye); omega 3 polyunsaturated fatty acids. Few epidemiological studies have been conducted this field, particularly Europe.
While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association more controversial with age-related macular degeneration (AMD). We report the associations of lifetime ambient UVR cataract extraction and AMD.The Alienor Study population-based study 963 residents Bordeaux (France), aged 73 years or more. Lifetime was estimated from residential history Eurosun satellite-based estimations ground UVR. It divided in three groups (lower quartile, intermediate...
Previous research has suggested an association between dementia and glaucoma through common risk factors or mechanisms. Our aim was to evaluate the longitudinal relationship open-angle (OAG) incident dementia.The Three-City-Bordeaux-Alienor study is a population-based cohort of 812 participants with 3-year follow-up period. All were aged 72 years older. An eye examination performed on all subjects. OAG determined based optic nerve damage visual field loss. Incident actively screened for...
While the prevalence of age-related macular degeneration (AMD) differs according to continents and races/ethnicities, its incidence in European continent has been scarcely documented.To describe associated risk factors AMD elderly French individuals.This population-based cohort study 963 residents Bordeaux, France, who were 73 years or older at baseline participated Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (ALIENOR) Study between October 2, 2006, December 21, 2012....
To compare the efficacy and safety of submacular hemorrhage (SMH) management using either surgical pars plana vitrectomy (PPV) or pneumatic displacement (PD) with tissue plasminogen activator (tPA) vascular endothelial growth factor (VEGF) inhibitor added to each arm.Randomized, open-label, multicenter superiority study.Ninety patients neovascular age-related macular degeneration (nAMD) 50 years age older recent SMH (≤ 14 days) more than 2 optic disc areas predominantly overlying retinal...
Previous studies have suggested a lower risk for age-related maculopathy (ARM) in subjects with high dietary intake of long-chain omega-3 polyunsaturated fatty acids (PUFA). The authors report the associations ARM past intakes French elderly subjects.The Alienor Study is population-based epidemiologic study on nutrition and eye diseases performed residents Bordeaux 73 years age older. Six hundred sixty-six (1289 eyes) complete data were included analyses. was classified from retinal...
Purpose: To document reticular pseudodrusen (RPD) using multimodal imaging in French elderly subjects. Methods: A total of 494 subjects (970 eyes) aged 77 years or more, from the Alienor study, were examined 2011 and 2012. Reticular defined as definite if they present with at least two methods among color retinal photographs, macular cube (20° × 15°) spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), infrared reflectance (IR). The Youden index was...
Nutritional uptake of lutein, zeaxanthin, and ω-3 polyunsaturated fatty acids may increase macular pigment optical density (MPOD) thereby protect against the development age-related degeneration (AMD).To estimate efficiency dietary supplementation containing acids, vitamins to in first-generation offspring parents with neovascular AMD.This study was a randomized clinical trial (Lutein Influence on Macula Persons Issued From AMD Parents [LIMPIA]) 6-month treatment period, followed by...
Purpose.: To explore the association of AMD with long-term average blood pressure (BP) parameters, including pulse (PP). Methods.: The ALIENOR study is a population-based on age-related eye diseases in 963 residents Bordeaux, France, aged 73 years or older. was graded from nonmydriatic color retinal photographs, three exclusive stages: no (1015 eyes), large soft distinct drusen and/or indistinct reticular pigmentary abnormalities (early AMD, 276 and late (66 eyes). BP parameters were...
To assess the associations of complement factor H (CFH) Y402H polymorphism and smoking with specific features early AMD (type, location, area).The ALIENOR study is a population-based age-related eye diseases in 963 residents Bordeaux (France), aged 73 years or more. were graded from nonmydriatic color retinal photographs. CFH was genotyped by using DNA extracted blood. Statistical analyses included 796 subjects complete data.CFH CC genotype strongly associated late neovascular (OR, 6.0; 95%...
<h3>Importance</h3> The eye is a sensory organ that easily accessible for imaging techniques, allowing the measurement of retinal nerve fiber layer (RNFL) thickness. part central nervous system, and its neurons may be susceptible to degeneration; therefore, changes in RNFL thickness reflect microstructural volume alterations brain. <h3>Objective</h3> To explore association between peripapillary brain visual limbic networks elderly people without dementia. <h3>Design, Setting,...
Lutein and zeaxanthin may lower the risk of age-related macular degeneration (AMD). We evaluated associations plasma lutein with incidence advanced AMD in Alienor study (Antioxydants Lipides Essentiels Nutrition et Maladies Oculaires). is a prospective population-based cohort 963 residents Bordeaux, France, who were 73 years or older at baseline (2006–2008). The present included 609 participants complete ophthalmologic carotenoids data. Examinations performed every two over an eight-year...
Background Retinal detachment often leads to a severe and permanent loss of vision its therapeutic management remains this day exclusively surgical. We have used surgical specimens perform differential analysis the transcriptome human retinal tissues following in order identify new potential pharmacological targets that could be combination with surgery further improve final outcome. Methodology/Principal Findings Statistical reveals major involvement immune response disease. Interestingly,...
To assess the correlation between macular pigment optical density and plasma levels of lutein, zeaxanthin, fatty acids, especially omega-3 polyunsaturated acids (PUFAs).The PIMAVOSA study is an observational 107 healthy volunteers, aged 20 to 60 years born in southwest France, without histories ocular disease. Macular (MPOD) was measured using two-wavelength autofluorescence method with a modified scanning laser ophthalmoscope. Plasma measurements (lutein, acids) were performed from fasting...
BackgroundSeveral genes implicated in high-density lipoprotein (HDL) metabolism have been reported to be associated with age-related macular degeneration (AMD). Furthermore, HDL transport the two carotenoids, lutein and zeaxanthin, which are highly suspected play a key-role protection against AMD. The objective is confirm associations of HDL-related loci AMD assess their plasma zeaxanthin concentrations. MethodsAlienor study prospective population-based on nutrition eye diseases performed...