A5070819093- Fatty Acid Research and Health
- Diet and metabolism studies
- Infant Nutrition and Health
- Diet, Metabolism, and Disease
- Antioxidant Activity and Oxidative Stress
- Lipid metabolism and biosynthesis
- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Nutritional Studies and Diet
- Proteins in Food Systems
- Liver Disease Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Retinoids in leukemia and cellular processes
- Saffron Plant Research Studies
- Breastfeeding Practices and Influences
- Food Chemistry and Fat Analysis
- Peroxisome Proliferator-Activated Receptors
- Biochemical effects in animals
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Muscle metabolism and nutrition
- Medicinal Plants and Bioactive Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism and Genetic Disorders
- Nuts composition and effects
Institut des Corps Gras
2015-2024
Centre Hospitalier Universitaire de Clermont-Ferrand
2024
MetaboHUB
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Centre Hospitalier Universitaire de Bordeaux
2024
Inserm
2014-2024
French Clinical Research Infrastructure Network
2024
Centre de recherche Translationnelle en Médecine moléculaire
2021-2022
Université de Bordeaux
2004-2021
CHU Dijon Bourgogne
2021
The nature of emulsifiers modulates ALA bioavailability by modifying the gastrointestinal lipolysis lipid emulsions.
Enhanced adiposity and metabolic inflammation are major features of obesity that could be impacted by dietary emulsifiers. We investigated in high-fat fed mice the effects using a new polar lipid (PL) emulsifier from milk (MPL) instead soybean lecithin (soybean PL [SPL]) on adipose tissue intestinal mucosa function.Four groups C57BL6 received for 8 wks low-fat (LF) diet or devoid PLs an including MPL (high-fat-MPL) SPL (high-fat-SPL). Compared with diet, high-fat-SPL increased white (WAT)...
This multicenter non-inferiority study evaluated the safety of infant formulas enriched with bovine milk fat globule membrane (MFGM) fractions.Healthy, full-term infants (n = 119) age ≤14 days were randomized to standard formula (control), a lipid-rich MFGM fraction (MFGM-L), or protein-rich (MFGM-P). Primary outcome was mean weight gain per day from enrollment 4 months (non-inferiority margin: -3.0 g/day). Secondary (length, head circumference, tolerability, morbidity, adverse events) and...
The bioavailability of α-linolenic acid (ALA) from flaxseed oil in an emulsified form v. a non-emulsified was investigated by using two complementary approaches: the first one dealt with characterisation emulsion vitro gastrointestinal-like conditions; second compared intestinal absorption ALA rats fed forms oil. study on showed that decreasing pH 7·3 to 1·5 at physiological temperature (37°C) induced instantaneous globule coalescence. Some phase separation observed under acidic conditions...
Anxiety, stress, and low mood are closely related may contribute to depressive symptoms. Among non-pharmacological solutions improve subclinical symptoms resilience natural products such as saffron—identified promising following preliminary beneficial effects in major disorder—represent a relevant strategy. This study aimed assess the efficacy of 8 weeks' supplementation with 30 mg standardized saffron extract on emotional well-being healthy adults feelings anxiety and/or stress evaluate...
In vitro digestion studies often use animal digestive enzyme extracts as substitutes of human gastric and pancreatic secretions. Pancreatin from porcine origin is thus commonly used to provide relevant enzymes such proteases, amylase lipase. Rabbit (RGE) have been recently introduced lipase in addition pepsin. Before preparing simulated with targeted activities described protocols, it important determine the preparations using validated methods. The purpose this inter-laboratory study within...
Background: Long-chain polyunsaturated fatty acids (LC-PUFAs) are important for newborn neurosensory development. Supplementation of breastfeeding mothers’ diets with omega-3 PUFAs, such as alpha-linolenic acid (ALA), may increase their concentration in human milk. Research aim: This study aimed to assess milk composition after 15-day supplementation regimens containing either PUFAs or olive oil, which does not provide ALA. Methods: A multicenter factorial randomized trial was conducted four...
Increases in oxidative stress have been reported to play a central role the vulnerability depression, and antidepressant drugs may reduce increased patients. Among plants exerting anti-inflammatory anti-oxidant properties, saffron, spice derived from flower of Crocus sativus, is also known for its positive effects on potentially through SSRI-like properties. However, molecular mechanisms underlying these their health benefits humans are currently unclear. Using an original ex vivo clinical...
The main risk factors for Alzheimer's disease, age and the ε4 allele of APOE gene (APOE4), might modify metabolism n-3 PUFAs in turn, their impact on cognition. aim this study was to investigate association between dietary fat plasma concentrations eicosapentaenoic acid (EPA) docosahexaenoic (DHA) elderly persons, taking APOE4 genotype into account. sample composed 1,135 participants from Three-City aged 65 years over, whom 19% were carriers. Mean proportions EPA [1.01%, standard deviation...
To assess the correlation between macular pigment optical density and plasma levels of lutein, zeaxanthin, fatty acids, especially omega-3 polyunsaturated acids (PUFAs).The PIMAVOSA study is an observational 107 healthy volunteers, aged 20 to 60 years born in southwest France, without histories ocular disease. Macular (MPOD) was measured using two-wavelength autofluorescence method with a modified scanning laser ophthalmoscope. Plasma measurements (lutein, acids) were performed from fasting...
This review focuses on the potential use, nutritional value and beneficial health effects of oilseeds as a source food protein. The process extracting oil from produces by-product that is rich in proteins other valuable bioactive components. product primarily used for animal feed. However, demand continues to rise, plant-based have real success applications. Among different plant protein sources, could be an alternative human diet. data we so far show present content up 40% relatively...
Synthetic emulsifiers have recently been shown to promote metabolic syndrome and considerably alter gut microbiota. Yet, data are lacking regarding the effects of natural emulsifiers, such as plant lecithins rich in essential α-linolenic acid (ALA), on health.For 5 days, male Swiss mice fed diets containing similar amounts ALA 0, 1, 3, or 10% rapeseed lecithin (RL) soy (SL). Following an overnight fast, they force-fed same oil mixture euthanized after 90 minutes. The consumption...
n -3 Long-chain PUFA ( LC-PUFA), particularly EPA and DHA, play a key role in the maintenance of brain functions such as learning memory that are impaired during ageing. Ageing is also associated with changes DHA content membranes could contribute to impairment. Limited studies have investigated effects ageing LC-PUFA supplementation on both blood fatty acid compositions. Therefore, we assessed relationship between contents plasma erythrocyte those hippocampus, striatum cerebral cortex...