A5040026047- Saffron Plant Research Studies
- Cardiovascular Function and Risk Factors
- Circadian rhythm and melatonin
- Medicinal Plants and Bioactive Compounds
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Cardiac Arrhythmias and Treatments
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Skin Protection and Aging
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- melanin and skin pigmentation
- Atrial Fibrillation Management and Outcomes
- Glioma Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Venous Thromboembolism Diagnosis and Management
- Dietary Effects on Health
- Nanoplatforms for cancer theranostics
- Cardiac electrophysiology and arrhythmias
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Cardiac Structural Anomalies and Repair
- Olfactory and Sensory Function Studies
- Neurological Disease Mechanisms and Treatments
Complexité, Innovation et Activités Motrices et Sportives
2019-2025
Inserm
2017-2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2021-2024
MetaboHUB
2024
Centre Hospitalier Universitaire de Bordeaux
2024
French Clinical Research Infrastructure Network
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2009-2024
Electrophysiology and Heart Modeling Institute
2016-2023
Centre de Recherche Cardio-Thoracique de Bordeaux
2017-2022
Université de Bordeaux
2009-2018
Multifunctional polymersomes loaded with maghemite nanoparticles and grafted an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing tumor grown from breast cancer cells, MR images show targeting enhanced retention of antibody-labeled at the site.
Glucocorticoids are released after hypothalamus-pituitary-adrenal axis stimulation by stress and act both in the periphery brain to bring about adaptive responses that essential for life. Dysregulation of response can precipitate psychiatric diseases, particular depression. Recent genetic studies have suggested glucocorticoid carrier transcortin, also called corticosteroid-binding globulin (CBG), may an important role response. We investigated effect partial or total transcortin deficiency...
Background Polyphenols are naturally occurring organic compounds found in plants. Research suggests that their intake reduces the risk of cognitive decline and related dementias. Grapes blueberries polyphenol-rich foods have attracted attention for potential cognitive-enhancing effects. Purpose Examine effects supplementation with a standardized patented grape blueberry extract (Memophenol™) on function older adults mild impairment. Study design Two-arm, 6 month, parallel-group, randomized,...
Despite an increasing level of evidence supporting the individual beneficial effect polyphenols on cognitive performance, information related to potential synergistic action these phytonutrients performance during a prolonged effort is currently lacking. This study investigated acute and sustained polyphenols-rich extract from grape blueberry (PEGB), working memory attention in healthy students intensive effort. In this randomised, cross-over, double blind study, 30 consumed 600 mg PEGB or...
Anxiety, stress, and low mood are closely related may contribute to depressive symptoms. Among non-pharmacological solutions improve subclinical symptoms resilience natural products such as saffron—identified promising following preliminary beneficial effects in major disorder—represent a relevant strategy. This study aimed assess the efficacy of 8 weeks' supplementation with 30 mg standardized saffron extract on emotional well-being healthy adults feelings anxiety and/or stress evaluate...
Depressive disorders represent a major public health concern and display continuously rising prevalence. Importantly, large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need identify further therapeutic strategies, including nutritional approaches using natural plant extracts with known beneficial impacts on health. In that context, growing evidence suggests saffron could be particularly...
Increases in oxidative stress have been reported to play a central role the vulnerability depression, and antidepressant drugs may reduce increased patients. Among plants exerting anti-inflammatory anti-oxidant properties, saffron, spice derived from flower of Crocus sativus, is also known for its positive effects on potentially through SSRI-like properties. However, molecular mechanisms underlying these their health benefits humans are currently unclear. Using an original ex vivo clinical...
Treatment of anxiety and depression predominantly centres around pharmacological interventions, which have faced criticism for their associated side effects, lack efficacy low tolerability. Saffron, is reportedly well tolerated in humans, has been recognised its antidepressant anti-anxiety properties. Indeed, we previously reported upon the saffron extract supplementation healthy adults with subclinical anxiety. However, molecular aetiology remains unclear. In a rodent model low-grade...
The Mediterranean diet (MD) and its bioactive constituents have been advocated for their neuroprotective properties along with capacity to affect gut microbiota speciation metabolism. Mediated through the brain axis, this modulation of may partly contribute MD. To explore potential interaction, we evaluated a novel blend (Neurosyn240) resembling in rodent model chronic low-grade inflammation. Behavioral tests cognition, proteomic analysis, 16S rRNA sequencing, 1H NMR metabolomic analyses...
Belight3TM, a nutricosmetic formulation containing polyphenol-rich extracts, has previously been demonstrated to be safe and effective in brightening skin color dark spots clinical study involving Asian volunteers. The aim of this was investigate the efficacy lightening Caucasian population, which is characterized by lighter pigmentation greater visibility hyperpigmentation, as well determine whether supplementation increased sensitivity UV exposure. A randomized, double-blind,...
Sleep disorders may increase neurodegenerative diseases risks and alter gut microbiota composition. Saffron (Crocus sativus) supplementation has been linked to sleep improvements microbiome changes, but its effect on quality through microbiota-brain axis modulation remains unexplored. A randomised, placebo-controlled pilot study of saffron (30mg/day for 4-weeks) was conducted with 52 older adults (55-85 years) experiencing complaints. Subjective objective were measured using validated...
<sec> <title>BACKGROUND</title> Sleep disturbances are highly prevalent and associated with an increased risk of mental physical health disorders. Given the limitations pharmacological treatments, natural interventions such as saffron extract have attracted growing interest for their potential to improve sleep stress-related outcomes. </sec> <title>OBJECTIVE</title> To examine effect a standardized (Safr’Inside™) on quality, insomnia symptoms, stress, psychological well-being in adults...
Aim: Natural interventions for sleep disturbances, such as saffron extract, are gaining scientific and clinical interest. This 3-arm, randomized, double-blind, placebo-controlled trial examined the effect of a standardized extract (Safr'InsideTM) on sleep, stress, other associated psychological outcomes in 165 men women reporting moderate insomnia. Methods: Participants received daily capsule containing 30 mg 20 or placebo (maltodextrin) 4 weeks. The primary endpoint was change insomnia...
Overhauser‐enhanced MRI (OMRI) offers the potentiality of detecting low‐concentrated species generated by specific biological processes. However molecular imaging applications OMRI need significant improvement in spatial localization. Here it is shown that 3D‐OMRI a free radical injected tumor‐bearing mice can be performed at high anatomical resolution constant field. A 30 mm cavity operating 5.43 GHz was inserted C‐shaped magnet for proton 0.194 T. Nude with or without brain‐implanted C6...
A knowledge of the spatial localization cell vehicles used in gene therapy against glioma is necessary before launching therapy. For this purpose, MRI tracking performed by labeling with contrast agents. In context, goal study was to follow noninvasively chemoattraction therapeutic microglial cells a human model triggering Silica nanoparticles grafted gadolinium were label microglia. These vehicles, expressing constitutively thymidine kinase suicide fused green fluorescent protein gene,...
Thrombotic risk constitutes a major complication of atrial fibrillation (AF). Platelets and microparticles (MPs) are important for hemostasis thrombosis, however their participation during AF is not well known. The aim this study was to characterize platelet function MPs procoagulant fibrinolytic activity in patients determine the effects an acute-AF episode.Blood collected from paroxysmal (21) persistent (16) referred catheter ablation. Ten sinus rhythm 10days were induced allowing...
Background Papillary muscles are an important source of ventricular tachycardia (VT). Yet little is known about the role right (RV) endocavity structure, moderator band (MB). The aim this study was to determine characteristics MB that may predispose arrhythmia substrates. Methods Ventricular wedge preparations with intact MBs were studied from humans (n=2) and sheep (n=15; 40-50 kg). RV endocardium optically mapped, electrical recordings measured along septum. S1S2 pacing free wall, MB, or...
Oral formulations with natural plant-based extracts represent a safe and promising strategy for skin lightening anti-dark-spot effects, especially in Asia. This study evaluated the effect of an oral formulation including polyphenol-rich vitamin C (Belight3TM) on vitro tyrosinase inhibitory activity investigated its effects vivo. Tyrosinase was measured spectrophotometry. A randomized, double-blind, placebo-controlled clinical carried out 58 healthy Asian males females, aged 45–65. Skin color...
The dynamic protective capacity of (poly)phenols, attributed to their potent antioxidant and anti-inflammatory properties, has been consistently reported. Due alter gut microbiome composition, further actions (poly)phenols may be exerted through the modulation microbiota-gut-brain axis. However, underlying mechanisms remain poorly defined. Here, we investigated effect a (poly)phenol-rich grape blueberry extract (Memophenol™), on axis in model chronic low-grade inflammation (0.5 mg/kg/wk...
Depressive disorders are a major public health concern. Despite currently available treatment options, their prevalence steadily increases, and high rate of therapeutic failure is often reported, together with important antidepressant-related side effects. This highlights the need to improve existing strategies, including by using nutritional interventions. In that context, saffron recently received particular attention for its beneficial effects on mood, although underlying mechanisms...
Cardiac fiber direction is an important factor determining the propagation of electrical activity, as well development mechanical force. In this article, we imaged ventricles several species with special attention to intraventricular septum determine functional consequences septal organization. First, identified a dual-layer organization orientation in ex vivo sheep hearts using diffusion tensor imaging at high field MRI. To expand scope results, investigated presence similar five mammalian...
Background Although activation of inflammatory processes is essential to fight infections, its prolonged impact on brain function well known contribute the pathophysiology many medical conditions, including neuropsychiatric disorders. Therefore, identifying novel strategies selectively counter harmful effects neuroinflammation appears as a major health concern. In that context, this study aimed test relevance nutritional intervention with saffron, spice for centuries beneficial effect...