A5065596403- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Adolescent Sexual and Reproductive Health
- Liver Disease Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- HIV/AIDS Impact and Responses
- Pneumocystis jirovecii pneumonia detection and treatment
- Global Maternal and Child Health
- Hepatitis B Virus Studies
- Child Nutrition and Water Access
- Poverty, Education, and Child Welfare
- Breastfeeding Practices and Influences
- Systemic Lupus Erythematosus Research
- Healthcare Systems and Practices
- Liver Disease and Transplantation
- Neonatal Respiratory Health Research
- Tuberculosis Research and Epidemiology
- Pregnancy and Medication Impact
- Immunodeficiency and Autoimmune Disorders
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Renal Diseases and Glomerulopathies
Inserm
2016-2025
Université de Toulouse
2016-2025
Sciences, Philosophie, Histoire
2022-2025
Centre de recherche en Epidémiologie et Santé des Populations
2022-2025
Université Toulouse III - Paul Sabatier
2016-2025
Centre d'Étude et de Recherche Travail Organisation Pouvoir
2025
Centre Hospitalier Universitaire de La Réunion
2016-2025
Laboratoire Interdisciplinaire Solidarités Sociétés Territoires
2023-2024
Université de Tours
2024
Collaborative Group (United States)
2023
No AccessJournal of UrologyPediatric urology1 Feb 2008Antibiotic Prophylaxis for the Prevention Recurrent Urinary Tract Infection in Children With Low Grade Vesicoureteral Reflux: Results From a Prospective Randomized Studyis accompanied byVesicoureteral RIVUR Study and Way Forward G. Roussey-Kesler, V. Gadjos, N. Idres, B. Horen, L. Ichay, M.D. Leclair, F. Raymond, A. Grellier, I. Hazart, de Parscau, R. Salomon, Champion, Leroy, Guigonis, D. Siret, J.B. Palcoux, S. Taque, Lemoigne, J.M....
Objective. To compare morbidity and mortality of human immunodeficiency virus type 1 (HIV-1)-infected HIV-1-uninfected children to identify predictors acquired syndrome (AIDS) death among HIV-1-infected in the context a developing country. Design. Prospective cohort study. Setting. Maternal child health clinic Centre Hospitalier de Kigali, Rwanda. Participants. Two hundred eighteen born HIV-1-seropositive mothers 218 seronegative same age parity were enrolled at birth. Outcome Measures....
ABSTRACT There is an urgent need for low-cost human immunodeficiency virus type 1 (HIV-1) viral load (VL) monitoring technologies in resource-limited settings. An automated TaqMan real-time reverse transcription-PCR (RT-PCR) assay was transferred to the laboratory of Centre de Diagnostic et Recherches sur le SIDA, Abidjan, Côte d'Ivoire, and assessed HIV-1 RNA VL testing 806 plasma samples collected within four ANRS research programs. The detection threshold reproducibility were first...
Background Previously, HIV epidemic models have used a double Weibull curve to represent high initial and late mortality of HIV-infected children, without distinguishing timing infection (peri- or post-natally). With more data on infection, which may be associated with disease progression, separate representation children infected early was proposed.
The aim of this study was to develop a population pharmacokinetic model tacrolimus in pediatric kidney transplant patients, identify factors that explain variability, and determine dosage regimens. Pharmacokinetic samples were collected from 50 de novo patients (age 2–18 years) who on treatment. Population analysis performed using NONMEM, the impact variables (demographic clinical factors, CYP3A4–A5, ABCB1, ABCC2 polymorphisms) tested. data described by two–compartment incorporated...
Background Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric cohorts and cohort networks, allowing comparisons in "real-life" settings across multiple regions. We describe geographic temporal characteristics mortality outcomes APHs regions, including South America Caribbean, North America, Europe, sub-Saharan Africa, Southeast Asia. Methods findings Through Collaborative...
Abstract Introduction: The number of adolescents with perinatally or behaviourally acquired HIV is increasing in low‐income countries, and especially sub‐Saharan Africa where prevalence incidence are the highest. As they survive into adulthood era antiretroviral therapy, there a pressing need to transfer them from paediatric adult care, known as transition care. We conducted narrative review recent evidence on their outcomes Africa, highlighting specific needs challenges these populations...
We assessed the effect of HIV status disclosure on retention in care from initiation antiretroviral therapy (ART) among HIV-infected children aged 10 years or more Cote d'Ivoire, Mali and Sénégal.
We describe the 24-month incidence of Dolutegravir (DTG)-containing antiretroviral treatment (ART) initiation since its introduction in 2019 West Africa. included all patients aged 0-24 years on ART from nine clinics Côte d'Ivoire (n=4), Ghana, Nigeria, Mali, Benin, and Burkina Faso. Baseline varied by clinic was defined as date first DTG prescription; were followed up until database closure/death/loss to follow-up (LTFU, no visit ≥7 months), whichever came first. computed cumulative...
Group Interpersonal Therapy (IPT), an evidence-based treatment of depression recommended by the WHO mhGAP Intervention Guide, was implemented through a task-shifting approach in Senegal, as for depressed people living with HIV (PLWH). Since description resources used and implementation costs incurred is necessary to inform policymakers better, this study aimed estimate associated its implementation. were analyzed using "ingredients-based costing approach" from provider's perspective. We...
To assess the 24 month efficacy of a maternal short-course zidovudine regimen to prevent mother-to-child transmission (MTCT) HIV-1 in breastfeeding population West Africa. Data were pooled from two clinical trials: DITRAME-ANRS049a conducted Abidjan, Côte d'Ivoire and Bobo-Dioulasso, Burkina-Faso RETRO-CI, Abidjan. Between September 1995 February 1998, consenting HIV-1-seropositive women randomly assigned receive (300 mg) or placebo: one tablet twice daily 36-38 weeks' gestation until...
ABSTRACT. Transferrin receptor (TfR) has been identified as a candidate IgA1 expressed on human mesangial cells (HMC). TfR binds but not IgA2, co-localizes with deposits, and is overexpressed in patients IgA nephropathy (IgAN). Here, structural requirements of for its interaction were analyzed. Polymeric monomeric interacted cultured HMC mediates internalization. binding was significantly inhibited (>50%) by soluble forms both TfR1 TfR2, confirming that serves receptor. Hypogalactosylated...
Abstract A retrospective survey estimating the prevalence of hepatitis viruses B (HBV) and C (HCV) was conducted on samples taken in 1,002 African pregnant women (501 diagnosed as HIV‐1 positive 501 negative) participating a clinical trial program Abidjan, Côte d'Ivoire (West Africa). Hepatitis markers studied were HBs antigen (HBsAg), if positive, HBe antigen/anti‐HBe antibodies HBV DNA. Two third generation (G3) HCV enzyme immunoassays (EIAs) used for primary screening. All anti‐HCV...
Background Highly active antiretroviral treatment (HAART) has only been recently recommended for HIV-infected pregnant women requiring their own health in resource-limited settings. However, there are few documented experiences from African countries. We evaluated the short-term (4 wk) and long-term (12 mo) effectiveness of a two-tiered strategy prevention mother-to-child transmission HIV (PMTCT) Africa: meeting eligibility criteria World Health Organization (WHO) received HAART, with less...
Background: In the context of DITRAME-ANRS 049 research program that evaluated interventions aimed at reducing mother-to-child transmission HIV (MTCT) in Bobo-Dioulasso (Burkina Faso), Voluntary counseling and testing (VCT) services were established for pregnant women. HIV-infected women advised to disclose their serostatus male partners who also offered VCT, use condoms reduce sexual transmission, choose an effective contraception method avoid unwanted pregnancies. This study assessing how...
Pregnancy outcomes in women receiving highly active antiretroviral treatment (HAART) Africa are not well described.HIV-1-infected pregnant the ANRS Ditrame Plus and MTCT-Plus projects were included. Between March 2001 July 2003, when HAART was yet available, eligible for received a short-course regimen, zidovudine (ZDV) or (ZDV + lamivudine) single dose of nevirapine preventing mother-to-child transmission (PMTCT group). August 2003 2007, it (HAART The frequencies low birth weight (LBW)...
To assess the 9-month HIV-free survival of children with two strategies to prevent HIV mother-to-child transmission.
Background In Africa, women tested for HIV during antenatal care are counselled to share with their partner test result and encourage partners undertake testing. We investigate, among within a prevention of mother-to-child transmission (PMTCT) programme, the key moments disclosure own status impact on Methods Findings Within Ditrame Plus PMTCT project in Abidjan, 546 HIV-positive 393 HIV-negative were pregnancy followed-up two years after delivery. Circumstances, frequency, determinants male...
Background: To date, an estimated 10% of children eligible for antiretroviral treatment (ART) receive it, and the frequency retention in programs is unknown. We evaluated 2-year risks death loss to follow-up (LTFU) after ART initiation a multicenter study sub-Saharan Africa. Methods: Pooled analysis routine individual data from 16 participating clinics produced overall Kaplan-Meier estimates probabilities or LTFU initiation. Risk factors used Weibull regression, accounting between-cohort...