A5012017535- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Alcohol Consumption and Health Effects
- Abdominal vascular conditions and treatments
- Gallbladder and Bile Duct Disorders
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Imaging and Diagnostics
- Genetic Associations and Epidemiology
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Protein Kinase Regulation and GTPase Signaling
- Galectins and Cancer Biology
- Tissue Engineering and Regenerative Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Mechanisms and Therapy
- Diet, Metabolism, and Disease
- Vascular Anomalies and Treatments
- Biomedical and Chemical Research
- Biliary and Gastrointestinal Fistulas
- Obstructive Sleep Apnea Research
McGill University Health Centre
2024-2025
Vanderbilt University Medical Center
2019-2024
Vanderbilt University
2011-2021
Massachusetts General Hospital
2017
Harvard University
2017
University of Washington
2008-2010
Seattle University
2010
University of Washington Medical Center
2007
University of North Carolina at Chapel Hill
2003
Centre For Digestive Diseases
2003
Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor that reduces portal hypertension rats was safe well tolerated phase 1 studies. We performed a 2b, randomized trial the safety efficacy patients NASH, cirrhosis, hypertension.Patients (hepatic venous pressure gradient [HVPG] ≥ 6 mm Hg) from 36 centers were randomly assigned, double-blind manner, groups...
Following a fibrogenic stimulus, the hepatic stellate cell (HSC) undergoes complex activation process associated with increased proliferation and excess deposition of type I collagen. The focal adhesion kinase (FAK)-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway is activated by platelet-derived growth factor (PDGF) in several types. We investigated role FAK-PI3K-Akt HSC activation. Inhibition FAK activity blocked migration, attachment, PDGF-induced PI3K Akt Both serum-...
Liver fibrosis is characterized by a dramatic increase in the expression of type I collagen. Several deoxyribonuclease (DNase) I-hypersensitive sites (HS) have been located distal 5′-flanking region α1(I) collagen gene that are specific to collagen-producing cells. To assess role DNase I-HS regulating hepatic stellate cells (HSCs), 3 transgenic mouse lines expressing collagen-α1(I) reporter genes were used (Krempen et al. Gene Expr 1999;8:151-163). The pCol9GFP transgene contains promoter...
Summary Background Limited data exist on the burden and features of non‐cirrhotic hepatocellular carcinoma (HCC) in United States. Aim To evaluate characteristics, aetiologies, trends outcomes HCC from 2000 to 2014 at five large US centres Methods Patient, tumour liver disease aetiology were collected. The presence underlying cirrhosis was assessed based published criteria. Results Of 5144 eligible patients with HCC, 11.7% had no cirrhosis. Non‐cirrhotic older (64.1 vs 61.2 years), more...
INTRODUCTION: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, affecting men to women at a ratio about 4:1. Risk factors, characteristics, and outcomes for HCC in United States remain poorly understood; therefore, we aim explore gender differences further. METHODS: Patients diagnosed with between January 2000 June 2014 5 large centers were identified. Clinical information, tumor survival data extracted manually. The presence underlying cirrhosis...
Hepatocellular carcinoma (HCC) has a strong racial and ethnic association, with Hispanic patients having higher incidence mortality. However, there are limited data regarding clinical features outcomes. This study includes non-Hispanic White HCC diagnosed between January 2000 June 2014 from five United States academic medical centers. The chi-square test for categorical variables analysis of variance continuous were used statistical analysis, two-tailed P < 0.05 considered statistically...
To identify risk factors associated with hepatocellular carcinoma (HCC), describe tumor characteristics and treatments pursed for a cohort of individuals nonalcoholic steatohepatitis (NASH) cirrhosis.We conducted retrospective case-control study well-characterized patients among five liver transplant centers NASH cirrhosis (cases) without HCC (controls).Ninety-four cases 150 controls were included. Cases significantly more likely to be male than (67% vs 45%, P < 0.001) older age (61.9 years...
Fontan-associated liver disease universally affects adults with single ventricle heart disease. Chronic kidney is also highly prevalent in adult Fontan patients. In this study, we evaluate the relationship of hemodynamics invasively and noninvasively extra-cardiac dysfunction as measured by MELD MELD-XI.We hypothesize that invasive noninvasive measures circuit congestion ventricular are associated increased MELD-XI scores.Single-center data from palliation who had ongoing care, including...
Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common global cause of chronic and remains under‐recognized within healthcare systems. Therapeutic interventions are rapidly advancing for its inflammatory phenotype, nonalcoholic steatohepatitis (NASH) at all stages disease. Diagnosis codes alone fail to recognize stratify at‐risk patients accurately. Our work aims identify NAFLD large electronic health record (EHR) databases automated stratification targeted intervention based...
Introduction: The burden of hepatocellular carcinoma (HCC) occurring in patients with alcoholic liver disease (ALD) is increasing at an alarming rate. aims this study were to compare the patient and tumor characteristics HCC ALD-alone relative addition other chronic diseases. Methods: Patients diagnosed between 2000 2014 identified 5 US clinical centers. categorized as ALD-alone, ALD plus viral hepatitis, or a non-ALD etiology. Clinical among 3 groups compared, survival probability was...
Background: Current chemotherapy for advanced hepatocellular carcinoma (HCC) is insufficient; only sorafenib has been proven to provide a modest survival benefit. A future direction of tailor treatment based on the chemosensitivity each individual tumor. By doing so, patients who stand benefit from therapy will be exposed potential side‐effects and morbidity. Although use docetaxel (DTX) lung, breast gastric cancer reported, there are few reports about its in setting HCC. Methods: To examine...
Nonalcoholic steatohepatitis is a growing indication for liver transplant. We examined multiple granular elements to determine risk factors recurrence of nonalcoholic or fatty disease.This retrospective, single-center study patients who underwent transplant steatohepatitis. Demographic differences were assessed with the Wilcoxon and Pearson tests continuous discrete variables, respectively. used linear mixed effects model estimate mean changes in body mass index laboratory measurements. Time...
INTRODUCTION: Drug-induced liver injury (DILI) is a leading cause of acute in the US, most commonly caused by antibiotics and NSAIDS. The clinical history biochemical pattern are often important clues to diagnosis classic can save patient an invasive procedure such as biopsy. It becomes diagnostically challenging when presentation inconsistent with drug reported, this case. CASE DESCRIPTION/METHODS: A 34-year old Caucasian man presented hospital progressive jaundice, vomiting malaise....
ABSTRACT Portal hypertension is a syndrome marked by an increase in the pressure of portal vein. can be diagnosed clinically or if measurement hepatic venous gradient greater than 5 mm Hg. Cirrhosis most common etiology Western countries, but there are other causes which lead to presinusoidal hypertension. We present patient with rare cause