A5012512596- Fibromyalgia and Chronic Fatigue Syndrome Research
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Health, psychology, and well-being
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Psychosomatic Disorders and Their Treatments
- Viral gastroenteritis research and epidemiology
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- Eosinophilic Disorders and Syndromes
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Ion Channels and Receptors
- Tuberculosis Research and Epidemiology
- Genetic Neurodegenerative Diseases
- S100 Proteins and Annexins
- Histiocytic Disorders and Treatments
- COVID-19 and Mental Health
Northwestern University
2014-2025
Lurie Children's Hospital
2015-2025
Virginia Tech
2019-2025
Tennessee Department of Health
2020-2023
Edmond and Lily Safra Children's Hospital
2022
University of California, Irvine
2022
Tel Aviv University
2015-2021
Tel Aviv Sourasky Medical Center
2020-2021
Hebrew University of Jerusalem
2019
University of Michigan
2016
Fatal T-cell lymphomas developed in three patients with a chronic illness manifested by fever, pneumonia, dysgammaglobulinemia, hematologic abnormalities, and extraordinarily high titers of antibody to the Epstein–Barr virus (EBV) capsid antigen (>10,000) early (>640) but low EBV nuclear (≤40). To understand pathogenesis these tumors better, we determined immunophenotype tumor cells analyzed tumor-cell DNA for genomes lymphoid-cell gene rearrangements. More than 80 percent had an activated...
OBJECTIVE: The goal was to characterize prospectively the course and outcome of chronic fatigue syndrome in adolescents during a 2-year period after infectious mononucleosis. METHODS: A total 301 (12–18 years age) with mononucleosis were identified screened for nonrecovery 6 months by using telephone screening interview. Nonrecovered underwent medical evaluation, follow-up 12 24 After blind review, final diagnoses at 6, 12, made established pediatric criteria. RESULTS: Six, mononucleosis,...
Journal Article Latent and Replicating Forms of Epstein-Barr Virus DNA in Lymphomas Lymphoproliferative Diseases Get access Ben Z. Katz, Katz From the Departments Pediatrics, Epidemiology Public Health, Molecular Biophysics Chemistry, Yale University School Medicine Department Microbiology Immunology, North Carolina at Chapel Hill, New Haven, Connecticut 1Please address requests to reprints Dr. Medicine, 333 Cedar St., P.O. Box 3333, CT 06510. Search for other works by this author on: Oxford...
Abstract Sero-surveillance can monitor and project disease burden risk. However, SARS-CoV-2 antibody test results produce false positive results, limiting their efficacy as a sero-surveillance tool. False are associated with malaria exposure, understanding this association is essential to interpret from malaria-endemic countries. Here, pre-pandemic samples eight endemic non-endemic countries four continents were tested by ELISA measure Spike S1 subunit reactivity. Individuals acute infection...
Background. Pediatric vaccination has resulted in declines disease unvaccinated individuals through decreasing pathogen circulation the community. About 2 years after implementation of pediatric rotavirus United States, dramatic were observed both vaccinated and children. Whether this protection extends to adults is unknown. Methods. The prevalence rotavirus, as determined by Rotaclone enzyme immunoassay, who had stools submitted for bacterial stool culture (BSC) between February May...
Chronic granulomatous disease (CGD) is an uncommon primary immunodeficiency that can be inherited in X-linked (XL) or autosomal recessive (AR) manner. We reviewed our large, single-center US experience with CGD.We 27 patients at Ann & Robert H. Lurie Children's Hospital of Chicago from March 1985 to November 2013. Fisher exact test was used compare differences categorical variables, and Student t means for continuous variables. Serious infections were defined as those requiring intravenous...
NADPH oxidase generates reactive oxygen species that are essential to innate immunity against microbes. Like most enzymes, it is sensitive pH, although the relative importance of pH(o) and pH(i) has not been clearly distinguished. We have taken advantage electrogenic nature determine its pH dependence in patch-clamped individual human eosinophils using electron current indicate enzyme activity. Electron stimulated by PMA (phorbol myristate acetate) was recorded both perforated-patch...
Abstract: ADV has emerged as an important pathogen in children undergoing allogeneic HPCT. A prospective study of the epidemiology infection and preemptive therapy high risk infections HPCT was undertaken. Cultures throat, urine, stool for viral pathogens plasma PCR were obtained prior to transplantation, weekly first 100 days, then monthly one yr. Children developing high‐risk treated preemptively with cidofovir 1 mg/kg/day given three times wk. case‐controlled performed identify factors...
Symptomatic infection with Neisseria gonorrhoeae (Gc) is characterized by abundant neutrophil (PMN, polymorphonuclear leucocyte) influx, but PMNs cannot clear initial infection, indicating that Gc possess defences against PMN challenge. In this study, survival of liquid-grown was monitored after synchronous adherent, interleukin 8-treated human PMNs. 40-70% FA1090 survived 1 h exposure, which bacterial numbers increased. Assays viability dyes along soybean lectin to detect extracellular...
As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections; our objective was describe differences in immune activation post-infective CFS (PI-CFS) patients recovered controls. We studied 301 adolescents prospectively over 24 months following the diagnosis of monospot-positive infectious mononucleosis (IM). found an incidence at 6, 12 13%, 7% 4% respectively. Using chemiluminescent imaging we measured concentrations IL-1a, 1b, 2, 4, 5, 8,...
Validation of biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) across data sets has proven disappointing. As immune signature may be affected by many factors, our objective was to explore the shift in discriminatory cytokines ME/CFS subjects separated duration illness. Cytokine expression collected at rest multiple studies female (i) 18 years or younger, ill 2 less (n = 18), (ii) 18–50 age, 7 22), and (iii) age 50 older 28), 11 on average. Control were matched body...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) involves severe fatigue, unrefreshing sleep, and cognitive impairment, leading to functional difficulties; prior studies have not evaluated risk factors with behavioral immune data collected before developing ME/CFS. Up 5% of university students develop infectious mononucleosis (IM) annually, 9-12% meet criteria for ME/CFS 6 months later. We sought determine predictors ME/CFS.We enrolled college at the start school year (time 1),...
This review summarizes the current scope of understanding associated with two common post-infectious complications COVID-19 infection: Multi-System Inflammatory Syndrome in Children (MIS-C) and Post-Acute Sequelae SARS-CoV-2 infection (PASC). It identifies gaps knowledge issues that may limit ability to fill these gaps. provides a framework drive continued research. A comprehensive literature was performed, identifying seminal articles describing emergence MIS-C PASC, works from focused on...
This study focused on identifying risk factors for adolescent post-infectious chronic fatigue syndrome (CFS), utilizing a prospective, nested case–control longitudinal design in which over 300 teenagers with infectious mononucleosis (IM) were identified through primary care sites and followed. Baseline variables that gathered several months following IM, included autonomic symptoms, days bed since perceived stress, stressful life events, family difficulty functioning attending school,...
The DNA and nuclear antigens of Epstein-Barr virus (EBV) have been detected in specimens tissue non-Hodgkin lymphoma lymphocytic interstitial pneumonitis from patients with acquired immunodeficiency syndrome. To determine whether there is serologic evidence an active EBV infection these disorders, we conducted a case-control study. case were 10 children syndrome genome-positive or lymphoma. We randomly selected one or, if available, two matched control human for each index patient compared...
During the "respiratory burst," NADPH oxidase complex of phagocytes produces reactive oxygen species that kill bacteria and other invaders (Babior, B. M. (1999)<i>Blood</i> 93, 1464–1476). Electron efflux through is electrogenic (Henderson, L. M., Chappell, J. B., Jones, O. T. G. (1987) <i>Biochem. J.</i> 246, 325–329) compensated by H<sup>+</sup> proton channels reportedly are contained within gp91<sup>phox</sup> subunit oxidase. To test whether functions as a channel, we studied currents...
Journal Article Infection with Two Genotypes of Epstein-Barr Virus in an Infant AIDS and Lymphoma the Central Nervous System Get access Ben Z. Katz, Katz Departments Pediatrics, Epidemiology Public Health, Molecular Biophysics Biochemistry, Yale University School Medicine, New Haven, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar Warren A. Andiman, Andiman Robin Eastman, Eastman Kelsey Martin, Martin George Miller The Infectious Diseases, Volume...
Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators post-infection fatigue (PIF) and other syndromes to collaborate these enigmatic poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilising COFFI, pooled data stored biosamples will support both epidemiological laboratory research better understand etiology risk factors development progression PIF.Methods: COFFI consists...