A5069059655- Malaria Research and Control
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Decadence, Literature, and Society
- Viral Infections and Vectors
- Trauma and Emergency Care Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Financial Crisis of the 21st Century
- HIV Research and Treatment
- Tendon Structure and Treatment
- Healthcare Systems and Practices
- Reproductive tract infections research
- Orthopedic Surgery and Rehabilitation
- Mathematical and Theoretical Epidemiology and Ecology Models
- Innovations in Medical Education
- Head and Neck Surgical Oncology
- Shoulder Injury and Treatment
- Trauma Management and Diagnosis
- Sinusitis and nasal conditions
- COVID-19 and healthcare impacts
- Hepatitis C virus research
- Historical Economic and Social Studies
- Hemoglobinopathies and Related Disorders
London School of Hygiene & Tropical Medicine
2010-2024
University of Hertfordshire
2024
Queen Mary University of London
2021
University of London
2010-2021
NHS Lanarkshire
2018
University Hospital Crosshouse
2016
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2013
Cheikh Anta Diop University
2013
BackgroundSeasonal malaria chemoprevention (SMC) aims to prevent in children during the high transmission season. The Achieving Catalytic Expansion of SMC Sahel (ACCESS-SMC) project sought remove barriers scale-up seven countries 2015 and 2016. We evaluated project, including coverage, effectiveness intervention, safety, feasibility, drug resistance, cost-effectiveness.MethodsFor this observational study, we collected data on delivery, effectiveness, influence costs impact incidence...
Background Malaria transmission has declined substantially in the 21st century, but pregnant women areas of sustained still require protection to prevent adverse pregnancy and birth outcomes associated with malaria (MiP). A recent call action been issued address continuing low coverage intermittent preventive treatment (IPTp). This has, however, questioned by some, part due concerns about resistance sulphadoxine-pyrimethamine (SP), only drug currently recommended for IPTp. Methods findings...
Background It is recommended that children aged 3 months to five years of age living in areas seasonal transmission the sub-Sahel should receive Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) during malaria season. The purpose this study was evaluate safety SMC SPAQ when delivered by community health workers three districts Senegal where introduced over years, from first year, then up 10 age. Methods A surveillance system established record all...
Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from parity-dependent, that is, acquired over consecutive pregnancies. However, the status of placenta can only be assessed at delivery. Here, to better understand mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within general population observed histology. Our results suggest immunity resulting in less prolonged greater determinant...
SMC has been introduced widely in the Sahel since its recommendation by WHO 2012. This study, which provided evidence of feasibility that supported recommendation, included school-age and pre-school children. School-age children were not 2012 but bear an increasing proportion cases. In 2006, consultations with health-staff held to choose delivery methods. The preferred approach, door-to-door first daily-dose supervised a community-health-worker (CHW), was piloted subsequently evaluated on...
Background Seasonal Malaria Chemoprevention (SMC) is currently recommended for children under five in areas where malaria transmission highly seasonal. We explored children's caregivers' and community health workers' (CHWs) responses to an extended 5-month SMC programme. Methods Thirteen in-depth interviews eight focus group discussions optimal suboptimal 'uptake' of examine facilitators barriers uptake. Results There did not appear be major differences between caregivers with sub-optimal...
Home-based management of malaria (HMM) may improve access to diagnostic testing and treatment with artemisinin combination therapy (ACT). In the Sahel region, seasonal chemoprevention (SMC) is now recommended for prevention in children. It likely that combinations antimalarial interventions can reduce burden. This study assessed feasibility, effectiveness safety combining SMC HMM delivered by community health workers (CHWs).A cluster-randomised trial was carried out during two transmission...
Plasmodium falciparum in pregnancy is a major cause of adverse outcomes. We combine performance estimates standard rapid diagnostic tests (RDT) from trials intermittent screening and treatment (ISTp) with modelling to assess whether at antenatal visits improves upon current preventative therapy sulphadoxine-pyrimethamine (IPTp-SP). estimate that RDTs primigravidae first visit are substantially more sensitive than non-pregnant adults (OR = 17.2, 95% Cr.I. 13.8-21.6), sensitivity declines...
ABSTRACT Sulfadoxine-pyrimethamine with amodiaquine (SP-AQ) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children (IPTc), but the component not always well tolerated. We determined association between dosage by body weight and mild adverse events (AEs) investigated whether alternative age-based regimens could improve dosing accuracy tolerability, using data from two trials of IPTc Senegal, one which AQ dose was age other it category. Both...
Seasonal malaria chemoprevention (SMC) is a strategy for control recommended by the World Health Organization (WHO) since 2012 Sahelian countries. The Mali National Malaria Control Programme adopted plan pilot implementation and nationwide scale-up 2016. Given that SMC relatively new approach, there an urgent need to assess costs cost effectiveness of when implemented through routine health system inform decisions on resource allocation.Cost data were collected from in Kita district, which...
Attention was drawn by Colfis (1925) to the fact that, in Registrar-General's occupational mortality returns for 1911, printers and shoemakers "present unusual picture of a low general combined with high phthisis mor- tality ".Comparison other trades failed reveal evidence predisposing causes such as silicosis, alcoholism, or poverty, but both occupations men " worked indoors under circumstances which individuals are so congregated together facilitate passage infection from person ".Collis...
Objectives Malaria and curable sexually transmitted reproductive tract infections (STIs/RTIs) are associated with adverse pregnancy outcomes. This study reports the prevalence risk factors of STIs/RTIs, STI/RTI co-infection malaria among HIV-negative pregnant women at their first antenatal care visit in Kenya, Malawi Tanzania. Methods all gravidae (n=4680) were screened for syphilis point-of-care tests treated if positive. Separately, provided blood samples (n=4569) rapid plasma reagin (RPR)...