A5066490079- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Pesticide and Herbicide Environmental Studies
- Soil and Land Suitability Analysis
- Soil and Water Nutrient Dynamics
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Soil Carbon and Nitrogen Dynamics
- Agriculture and Rural Development Research
- Viral Infections and Outbreaks Research
- Stochastic processes and statistical mechanics
- COVID-19 epidemiological studies
- Bayesian Methods and Mixture Models
- Soil Geostatistics and Mapping
- Water Quality and Pollution Assessment
- Infectious Diseases and Tuberculosis
- Geographic Information Systems Studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- HIV/AIDS drug development and treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Chronic Disease Management Strategies
- Immunodeficiency and Autoimmune Disorders
- Pharmacological Effects and Toxicity Studies
- Global Maternal and Child Health
Ignace Deen Hospital
2008-2025
MRC Unit the Gambia
2025
University of Bamako
2020-2023
Mali-Folkecenter
2023
Gamal Abdel Nasser University of Conakry
2018-2023
Donka Hospital
2023
Carrier (United States)
2015-2020
Délégation Paris 7
2019
Inserm
2019
Université Paris Cité
2019
Shortening the course of treatment for tuberculosis would be a major improvement case management and disease control. This phase 3 trial assessed efficacy safety 4-month gatifloxacin-containing regimen treating rifampin-sensitive pulmonary tuberculosis.We conducted noninferiority, randomized, open-label, controlled involving patients 18 to 65 years age with smear-positive, rifampin-sensitive, newly diagnosed in five sub-Saharan African countries. A standard 6-month that included ethambutol...
A 9-month regimen of isoniazid can prevent active tuberculosis in persons with latent infection. However, the has been associated poor adherence rates and toxic effects.
Background Host-related and environment-related factors have been shown to play a role in the development of tuberculosis (TB), but few studies were carried out identify their respective roles resource-poor countries.
Activation of Th1 lymphocytes, IFN-γ production and macrophage activation are crucial in defense against Mycobacteria. In developing countries, Th2 IL-4 have been associated vitro with tuberculosis poor clinical outcome after treatment. Serological markers [soluble lymphocyte gene (LAG)-3] (IgE, solubleCD30, CCL22/macrophage-derived chemokine) activity were measured 414 HIV-negative patients from The Gambia Guinée healthy household community controls. Measurements repeated during treatment...
Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports inconsistent. We genotyped the VDR single-nucleotide (SNPs) FokI, BsmI, ApaI, and TaqI 1139 case patients control subjects 382 families from The Gambia, Guinea, Guinea-Bissau. transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI FokI-ApaI that were driven by increased transmission affected...
Interferon-gamma (IFN-gamma) is of central interest in the study tuberculosis. A number single-gene mutations have been identified IFN-gamma signaling pathway that predispose to severe mycobacterial disease, but relevance polymorphism within these genes common phenotype tuberculosis remains unclear.A total 1,301 individuals were included a large, detailed West African populations with pulmonary We investigated disease association encoding and its receptor subunits (IFNG, IFNGR1,...
The sst1 locus has been identified in a mouse model to control resistance and susceptibility of Mycobacterium tuberculosis infection. Subsequent studies have now Ipr1 (intracellular pathogen 1) be the gene responsible. is encoded within expressed lung lesions macrophages -resistant, but not -susceptible mice. We therefore examined closest human homologue , SP110, for its ability M. infection humans. In study families from Gambia we three polymorphisms that are associated with disease. On...
BackgroundTuberculosis causes significant morbidity and mortality worldwide, especially in sub-Saharan Africa. DC-SIGN, encoded by CD209, is a receptor capable of binding internalizing Mycobacterium tuberculosis. Previous studies have reported that the CD209 promoter single nucleotide polymorphism (SNP)-336A/G exerts an effect on expression associated with human susceptibility to dengue, HIV-1 tuberculosis humans. The present study investigates role -336A/G variant large sample individuals...
BACKGROUND: Shorter but effective tuberculosis treatment regimens would be of value to the community. High-dose rifampicin has been associated with more rapid and secure lung sterilization may enable shorter regimens. METHODS: We randomly assigned adults who were given a diagnosis rifampicin-susceptible pulmonary 6-month control regimen, similar 4-month regimen at 1200 mg/d (study 1 [SR1]), or 1800 2 [SR2]). Sputum specimens collected regular intervals. The primary end point was composite...
The aim of the study was to evaluate serological correlates active tuberculosis and response antituberculosis treatment in a cohort HIV-negative patients with pulmonary studied at diagnosis during Service de Pneumo-Phtisiologie, Centre Hospitalier-Universitaire Ignace Deen, Conakry, Republic Guinea. Two similar cohorts healthy households community controls were included study. Plasma samples obtained from 168 untreated patients, 167 household controls, controls. Serial plasma also 2 8 months...
To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, assess effects efavirenz co-administration a 50% increase dose rifampicin on pharmacokinetic parameters acetyl-isoniazid.TB/HIV-coinfected patients participating three-treatment-arm RAFA randomized controlled trial conducted West Africa were recruited into sub-study. Five serial blood samples collected single visit between 4 8 weeks after initiation antituberculosis treatment. Concentration-time...
The safety and efficacy of rifampin among people living with human immunodeficiency virus (PLHIV) or other health conditions is uncertain. We assessed completion, safety, 4 months vs 9 isoniazid PLHIV conditions.We conducted post hoc analysis 2 randomized trials that included 6859 adult participants Mycobacterium tuberculosis infection. Participants were 1:1 to 10 mg/kg/d 5 isoniazid. report drug-related adverse events (AE), active incidence HIV; renal failure receiving immunosuppressants;...
Background: Tuberculosis (TB) is a leading cause of morbidity and mortality in people living with human immunodeficiency virus (HIV). Data are very scarce on the burden TB HIV patients Sub-saharan African populations. This study aimed to determine prevalence pulmonary tuberculosis (PTB) associated factors among (HIV) three West countries: Benin, Guinea, Senegal. Methods: A cross-sectional was conducted outpatient care centres (one each country). All HIV-positive included this were routinely...
Purpose The PREgnancy Care Integrating translational Science, Everywhere Network was established to investigate specific placental disorders (pregnancy hypertension, preterm birth, fetal growth restriction and stillbirth) in sub-Saharan Africa. We created a repository of clinical social data with associated biological samples from pregnant non-pregnant women. Alongside this, local infrastructure expertise the field maternal child health research were enhanced. Participants Pregnant women...
ABSTRACT The effects on ventricular repolarization—recorded the electrocardiogram (ECG) as lengthening of QT interval—of acute tuberculosis and those standard alternative antituberculosis regimens are underdocumented. A correction factor (QTc) is introduced to make independent heart rate, translating into slope regression line between rate being close zero. ECGs were performed predosing 1 5 h postdosing (month 1, month 2, end treatment) around drugs' peak concentration time in patients...
In this study we assessed first-line anti-tuberculosis drug resistance and the genotypic distribution of Mycobacterium tuberculosis complex (MTBC) isolates that had been collected from consecutive new patients enrolled in two clinical trials conducted Guinea between 2005 2010. Among total 359 MTBC strains were analyzed study, 22.8% resistant to at least one first line drugs, including 2.5% multidrug 17.5% isoniazid resistance, with or without other drugs. addition, further characterization a...
Abstract Background Despite the predictive role of body weight variation in treatment outcome multidrug-resistant tuberculosis (MDR-TB), few corroborating data are available. We studied patients with MDR-TB to identify groups change and determine factors that influence these changes. Methods analyzed rifampicin resistance who were treated an regimen between June 07, 2016 22, 2018 at three major drug-resistant TB centers Guinea. Patients seen monthly until end treatment. Clinical was mass...
Abstract Background Most countries in Subsaharan Africa have well-established National Tuberculosis Control Programs with relatively stable routine performances. However, major epidemiological events may result significant disruptions. In March 2014, the World Health Organization announced outbreak of Ebola virus disease Guinea, a country high incidence TB and HIV. Our study aimed to assess impact on notification, treatment, surveillance, using main indicators. Methods This is retrospective...