A5014511115- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Diagnosis and treatment of tuberculosis
- Infection Control in Healthcare
- Vaccine Coverage and Hesitancy
- HIV, Drug Use, Sexual Risk
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 epidemiological studies
- HIV-related health complications and treatments
- Sex work and related issues
- Mycobacterium research and diagnosis
- Herpesvirus Infections and Treatments
- HIV/AIDS drug development and treatment
- Respiratory Support and Mechanisms
- Dermatological and Skeletal Disorders
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Disaster Response and Management
- Microbial infections and disease research
- Peripheral Neuropathies and Disorders
- Parathyroid Disorders and Treatments
Institut Supérieur Agronomique et Vétérinaire Valéry Giscard d'Estaing
2019-2025
Institut Curie
2024-2025
Zimmer Biomet (France)
2024-2025
Widener University
2025
NanoBio (United States)
2025
Centre Hospitalier National Universitaire de Fann
2016-2025
Mali-Folkecenter
2004-2024
Sorbonne Université
2019-2024
Hôpital Militaire Moulay Ismail
2023-2024
Military Hospital
2024
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced distress (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs patients with SARS–CoV-2-induced ARDS. Methods multicentre, double-blind, randomized, placebo-controlled (STROMA–CoV-2) recruited...
The role of herpes simplex virus (HSV) reactivation on morbidity and mortality in patients the intensive care unit requiring mechanical ventilation remains unknown.To determine whether preemptive treatment with intravenous acyclovir reduces duration HSV oropharyngeal reactivation.A double-blind, placebo-controlled randomized clinical trial was conducted 16 units France. Participants included 239 adults (age, >18 years) who received for at least 96 hours continued to receive 48 or more,...
Abstract Introduction In sub‐Saharan Africa, HIV prevalence remains high, especially among key populations. such situations, combination prevention including clinical, behavioural, structural and biological components, as well adequate treatment are important. We conducted a demonstration project at the Dispensaire IST , clinic dedicated to female sex workers ( FSW s) in Cotonou, on early antiretroviral therapy (E‐ ART or immediate “test‐and‐treat”) pre‐exposure prophylaxis (Pr EP ). present...
Objectives Point‐of‐care lung ultrasonography (US) is an alternative to chest radiography for imaging of suspected community‐acquired pneumonia (CAP) in children. We compared pediatric emergency department (ED) time metrics between children who received point‐of‐care US versus radiography. Secondary objectives were comparisons health system costs and other resources these groups. Methods This work was a retrospective matched cohort study aged 0 18 years academic urban ED imaged CAP with...
The universal test and treat strategy (UTT) was developed to maximize the proportion of all HIV-positive individuals on antiretroviral treatment (ART) virally suppressed, assuming that it will lead a reduction in HIV incidence at population level. evolution over time cross-sectional care cascade is determined by individual longitudinal trajectories through continuum underlying dynamics. purpose this paper quantify contribution each component change (in- out-migration, seroconversion, ageing...
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative characterized by extensive neurodegeneration and consequent severe memory loss. Apolipoprotein E4 (ApoE4) the strongest genetic risk factor for AD, with its pathological effects linked to structural instability altered interactions lipids other important proteins including amyloid beta (Aβ) tau (τ). Therefore, correcting stabilizing ApoE4 structure has emerged as promising therapeutic strategy mitigating detrimental...
Alzheimer's disease (AD) is a progressive neurodegenerative characterized by extensive neurodegeneration and consequent severe memory loss. Apolipoprotein E4 (ApoE4) the strongest genetic risk factor for AD, with its pathological effects linked to structural instability altered interactions lipids other important proteins including amyloid beta (Aβ) tau (τ). Therefore, correcting stabilizing ApoE4 structure has emerged as promising therapeutic strategy mitigating detrimental effects. In this...
Abstract Background Lower limb arterial calcification is a frequent, underestimated but serious complication of diabetes. The DIACART study prospective cohort designed to evaluate the determinants progression lower in 198 patients with type 2 Methods scores were determined by computed tomography at baseline and after mean follow up 31.20 ± 3.86 months. Serum RANKL (Receptor Activator Nuclear factor kB Ligand) bone remodeling, inflammatory metabolic parameters measured baseline. predictive...
Abstract Background The STROMA-CoV-2 study was a French phase 2b, multicenter, double-blind, randomized, placebo-controlled clinical trial that did not identify significant efficacy of umbilical cord-derived mesenchymal stromal cells in patients with SARS-CoV-2-induced acute respiratory distress syndrome. Safety on day 28 found to be good. aim our extended assess the 6- and 12-month safety UC-MSCs administration cohort. Methods A detailed multi-domain assessment conducted at 6 12 months...
Abstract Background Despite the predictive role of body weight variation in treatment outcome multidrug-resistant tuberculosis (MDR-TB), few corroborating data are available. We studied patients with MDR-TB to identify groups change and determine factors that influence these changes. Methods analyzed rifampicin resistance who were treated an regimen between June 07, 2016 22, 2018 at three major drug-resistant TB centers Guinea. Patients seen monthly until end treatment. Clinical was mass...
Objectives Neck masses are a common reason for presentations to the pediatric emergency department (PED). We sought determine agreement and time difference between point‐of‐care ultrasound (POCUS) imaging by physicians compared radiology children with neck in PED. Methods performed retrospective study of patients aged 0 18 years presenting our tertiary PED who received both POCUS physician imaging. Charts were reviewed diagnoses, final metrics. Results Seventy‐five met criteria. In 58 75...
Bovine tuberculosis (BTB) is a contagious, debilitating human and animal disease caused by Mycobacterium bovis, member of the complex. The study objective were to estimate frequency BTB, examine genetic diversity M. bovis population in cattle from five regions Mali determine whether involved active (TB) humans. Samples suspected lesions on at slaughterhouses collected. Mycobacterial smear, culture confirmation, spoligotyping used for diagnosis species identification. DNA TB patients was...
Across the globe, hand hygiene (HH) is promoted to fight spread of healthcare associated infections. Despite multiple ongoing HH campaigns and projects, infection rates remain high especially in low- middle-income countries. In narrative overview presented here, we aim share objectives, framework, successes challenges our long-term partnership Guinea offer guidance for other projects aiming sustainably improve HH.
The universal test-and-treat (UTT) strategy aims to maximize population viral suppression (PVS), that is, the proportion of all people living with HIV (PLHIV) on antiretroviral treatment (ART) and virally suppressed, goal reducing transmission at level. This article explores extent which temporal changes in PVS explain observed lack association between cumulative incidence seen ANRS 12249 TasP trial conducted rural South Africa.The cluster-randomized (2012 2016) implemented six-monthly...
Abstract Background In response to the COVID-19 pandemic, WHO launched a strategic preparedness and plan, outlining public health measures support countries worldwide. Healthcare workers have an increased risk of becoming infected their behaviour regarding infection prevention control (IPC) influences dynamics. IPC strategies are important across globe, but even more in low-resource settings where capacities for testing treatment limited. Our study aimed assess implement pandemic Faranah,...