A5106342009- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Family and Patient Care in Intensive Care Units
- SARS-CoV-2 and COVID-19 Research
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Cardiac Arrest and Resuscitation
- Antibiotic Use and Resistance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Healthcare Decision-Making and Restraints
- Glioma Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Pancreatic and Hepatic Oncology Research
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Autoimmune and Inflammatory Disorders Research
- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Parvovirus B19 Infection Studies
- Brain Metastases and Treatment
Sorbonne Université
2016-2025
Pitié-Salpêtrière Hospital
2013-2025
Assistance Publique – Hôpitaux de Paris
2015-2024
Neurophysiologie respiratoire expérimentale et clinique
2015-2024
Centre National de la Recherche Scientifique
2018-2024
Inserm
2018-2024
Centre Hospitalier Universitaire de Lille
2024
Université de Lille
2024
Unité de Glycobiologie Structurale et Fonctionnelle
2024
Hôpitaux Universitaires de Strasbourg
2022-2023
Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus control infection to a larger extent.
Intensive care unit (ICU)- and mechanical ventilation (MV)-acquired limb muscle diaphragm dysfunction may both be associated with longer length of stay worse outcome. Whether they are two aspects the same entity or have a different prevalence prognostic impact remains unclear.To quantify coexistence these forms ICU-acquired weakness their on outcome.In patients undergoing first spontaneous breathing trial after at least 24 hours MV, was evaluated using twitch tracheal pressure in response to...
Whether severe coronavirus disease (COVID-19) is a significant risk factor for the development of invasive fungal superinfections great medical interest and remains, now, an open question.
Invasive pulmonary aspergillosis is a complication in critically ill patients with acute respiratory distress syndrome, especially those severe influenza pneumonia. We report fatal case of invasive an immunocompetent patient France who had coronavirus disease-associated
Abstract A major dogma in immunology has it that the IgM antibody response precedes secondary memory responses built on production of IgG, IgA and, occasionaly, IgE. Here, we measured acute humoral to SARS-CoV-2, including frequency antibody-secreting cells and presence specific, neutralizing, antibodies serum broncho-alveolar fluid 145 patients with COVID-19. Surprisingly, early SARS-CoV-2-specific were found be typically dominated by isotype. Peripheral expansion IgA-plasmablasts...
Rationale: Because encouraging rates for hospital and long-term survival of immunocompromised patients in ICUs have been described, these are more likely to receive invasive therapies, like extracorporeal membrane oxygenation (ECMO).Objectives: To report outcomes treated with ECMO severe acute respiratory distress syndrome (ARDS) identify their pre-ECMO predictors 6-month mortality main ECMO-related complications.Methods: Retrospective multicenter study 10 international high volumes cases....
Poor sleep is common in intensive care unit (ICU) patients, where environmental factors contribute to reduce and fragment sleep. The objective of this study was evaluate the impact earplugs eye mask on architecture ICU patients. A single-center randomized controlled trial 64 patients conducted from July 2012 December 2013. Patients were randomly assigned with or without an inclusion until discharge. Polysomnography performed first day night following inclusion. primary outcome proportion...
Rationale: Breathing difficulties are highly stressful. In critically ill patients, they associated with an increased risk of posttraumatic manifestations. Dyspnea, the corresponding symptom, cannot be directly assessed in noncommunicative patients. This difficulty can circumvented using observation scales such as mechanical ventilation-respiratory distress scale (MV-RDOS). Objective: To investigate performance and responsiveness MV-RDOS to infer dyspnea intubated Methods: Communicative...
Abstract Background The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak is spreading worldwide. To date, no specific treatment has convincingly demonstrated its efficacy. Hydroxychloroquine and lopinavir/ritonavir have potential interest, but virological clinical data are scarce, especially in critically ill patients. Methods present report took the opportunity of compassionate use successive drug shortages to compare effects two therapeutic options, hydroxychloroquine,...
Objectives: To compare the respective impact of pressure support ventilation and naturally adjusted ventilatory assist, with without a noninvasive mechanical algorithm, on patient–ventilator interaction. Design: Prospective 2-month study. Setting: Adult critical care unit in tertiary university hospital. Patients: Seventeen patients receiving prophylactic postextubation ventilation. Interventions: Patients were randomly mechanically ventilated for 10 mins with: algorithm (PSV-NIV–),...
Background. Characteristics and outcomes of adult patients with disseminated toxoplasmosis admitted to the intensive care unit (ICU) have rarely been described. Methods. We performed a retrospective study on consecutive who were from January 2002 through December 2012 ICUs 14 university-affiliated hospitals in France. Disseminated was defined as microbiological or histological evidence disease affecting >1 organ immunosuppressed patients. Isolated cases cerebral excluded. Clinical data...
Abstract Background The optimal treatment duration and the nature of regimen antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. aim this study was to evaluate whether a antibiotic therapy is superior monotherapy in patients with PA-VAP terms reduction recurrence death, based on 186 included iDIAPASON trial, multicenter, randomized controlled trial comparing 8 versus 15 days PA-VAP. Methods Patients...
Background In critically ill patients receiving mechanical ventilation, dyspnoea is frequent, severe and associated with an increased risk of neuropsychological sequelae. We evaluated the efficacy sensory interventions targeting brain rather than respiratory system to relieve in mechanically ventilated patients. Methods Patients ventilation for ≥48 h reporting (unidimensional visual analogue scale (Dyspnoea-VAS)) first underwent pressure support then, random order, auditory stimulation...
Background Lymphopenia and the neutrophil/lymphocyte ratio may have prognostic value in COVID-19 severity. Objective We investigated neutrophil subsets functions blood bronchoalveolar lavage (BAL) of patients on basis patients’ clinical characteristics. Methods used a multiparametric cytometry profiling based to mature immature markers 146 critical or severe patients. Results The Discovery study (38 patients, first pandemic wave) showed that 80% Intensive Care Unit (ICU) develop strong...
The capacity of pre-existing immunity to human common coronaviruses (HCoV) cross-protect against de novo COVID-19is yet unknown. In this work, we studied the sera 175 COVID-19 patients, 76 healthy donors and 3 intravenous immunoglobulins (IVIG) batches. We found that most patients developed anti-SARS-CoV-2 IgG antibodies before IgM. Moreover, their IgGs react beta-HCoV, was present in early appearance IgG. This implied a recall-type antibody response generated. comparison, mounted an...
Abstract Introduction Human Herpesvirus-6 (HHV-6) DNAemia is not rare in intensive care unit (ICU) patients. However, evidence for a causal association of HHV-6 with organ disease and mortality limited this setting. In ICU patients DNAemia, we sought to 1) assess the prevalence disease, 2) identify risk factors 3) investigate its mortality. Methods Retrospective multicenter case-matched study three ICUs from January 2011 2022 viral load whole blood (genome equivalent copies/106 cells)...
Abstract Background Noninvasive ventilation (NIV) is the application of mechanical through a mask. It used to treat certain forms acute respiratory failure in intensive care units (ICU). NIV has clinical benefits but can be anxiogenic for patients. This study aimed at describing cognitive and affective attitudes toward among patients experiencing first time context an ICU stay. Methods Semi-structured interviews were conducted 10 during their stay soon after experience. None had ever...
Highlights Innate immune activation during Covid-19 infection is associated with pernicious clinical outcome. Background Coronavirus disease 2019 (Covid-19) a worldwide threat that has already caused more than 3 000 deaths. It characterized by different patterns of evolution depending on host factors among which old-age and pre-existing comorbidities play detrimental role. Previous coronavirus epidemics, notably SARS-CoV, were increased serum neopterin levels, can be interpreted as sign...
Abstract Background The STROMA-CoV-2 study was a French phase 2b, multicenter, double-blind, randomized, placebo-controlled clinical trial that did not identify significant efficacy of umbilical cord-derived mesenchymal stromal cells in patients with SARS-CoV-2-induced acute respiratory distress syndrome. Safety on day 28 found to be good. aim our extended assess the 6- and 12-month safety UC-MSCs administration cohort. Methods A detailed multi-domain assessment conducted at 6 12 months...