A5007227193- Respiratory Support and Mechanisms
- Inflammatory Myopathies and Dermatomyositis
- Muscle activation and electromyography studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Muscle Physiology and Disorders
- Body Composition Measurement Techniques
- Cardiovascular and exercise physiology
- Genetic Neurodegenerative Diseases
- Ultrasound in Clinical Applications
- Sports injuries and prevention
- Sports Performance and Training
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Prosthetics and Rehabilitation Robotics
- Transcranial Magnetic Stimulation Studies
- Neurogenetic and Muscular Disorders Research
- Ultrasound Imaging and Elastography
- Parkinson's Disease and Spinal Disorders
- Non-Invasive Vital Sign Monitoring
- Myasthenia Gravis and Thymoma
- Lower Extremity Biomechanics and Pathologies
- Congenital Diaphragmatic Hernia Studies
- Muscle and Compartmental Disorders
- Medical research and treatments
- Nerve Injury and Rehabilitation
- High Altitude and Hypoxia
Inserm
2010-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2017-2025
Neurophysiologie respiratoire expérimentale et clinique
2023-2025
Institut de Myologie
2016-2024
Pitié-Salpêtrière Hospital
2016-2021
Committee on Publication Ethics
2021
Novem (Netherlands)
2021
Université Grenoble Alpes
2010-2019
Physiopathologie et Epidémiologie des Maladies Respiratoires
2012-2018
Background The relationship between the diaphragm thickening fraction and transdiaphragmatic pressure, reference method to evaluate function, has not been clearly established. This study investigated global intraindividual of pressure. authors hypothesized that would be positively significantly correlated in both healthy participants ventilated patients. Methods Fourteen individuals 25 mechanically patients (enrolled two previous physiologic investigations) participated current study. zone...
Finding sensitive clinical outcome measures has become crucial in natural history studies and therapeutic trials of neuromuscular disorders. Here, we focus on 1-year longitudinal data from quantitative magnetic resonance imaging (MRI) phosphorus spectroscopy (
Greater diaphragm fatigue has been reported after hypoxic versus normoxic exercise, but whether this is due to increased ventilation and therefore work of breathing or reduced blood oxygenation per se remains unclear. Hence, we assessed the effect different level on isolated hyperpnoea-induced inspiratory expiratory muscle fatigue. Twelve healthy males performed three 15-min isocapnic hyperpnoea tests (85% maximum voluntary with controlled pattern) in normoxic, (SpO2 = 80%) hyperoxic (FiO2...
Background: Previous randomized controlled trials investigating exercise training programs in facioscapulohumeral muscular dystrophy (FSHD) patients are scarce and of short duration only. This study assessed the safety efficacy a 6-month home-based program on fitness, muscle, motor function FSHD patients. Methods: Sixteen were randomly assigned to (TG) control (CG) groups (both n = 8) intervention. Training consisted cycling 3 times weekly for 35 minutes (combination strength, high-intensity...
The reference method for the assessment of diaphragm function relies on measurement transdiaphragmatic pressure (Pdi). Local muscle stiffness measured using ultrafast shear wave elastography (SWE) provides reliable estimates force in locomotor muscles. This study aimed at investigating whether SWE could be used as a surrogate Pdi to evaluate function. Fifteen healthy volunteers underwent randomized stepwise inspiratory loading protocol 0–60% maximal isovolumetric during closed-airways...
<h3>Objective</h3> To assess long-term (2 years) effects of bimagrumab in participants with sporadic inclusion body myositis (sIBM). <h3>Methods</h3> Participants (aged 36–85 who completed the core study (RESILIENT [Efficacy and Safety Bimagrumab/BYM338 at 52 Weeks on Physical Function, Muscle Strength, Mobility sIBM Patients]) were invited to join an extension study. Individuals continued same treatment as (10 mg/kg, 3 1 mg/kg or matching placebo administered IV infusions every 4 weeks)....
Abstract Objective To assess quadriceps strength and fatigability by using femoral nerve magnetic stimulation (FNMS) their relationship to exercise capacity in patients with fibromyalgia syndrome (FMS) healthy controls. Methods Twenty‐two women (11 FMS, 11 controls) performed a maximal incremental cycling test fatigue on 2 separate visits. For assessment, we used FNMS during after maximum voluntary contraction (MVC) evaluate central peripheral factors of neuromuscular fatigue. Subjects sets...
Fibromyalgia (FM) is a chronic painful condition partly due to alterations in pain modulation by the central nervous system. Multicomponent therapy (MT) and repetitive transcranial magnetic stimulation (rTMS) have both been reported as modulators patients with FM. The aim of this study was compare effects rTMS on combination MT versus alone.Thirty-nine FM visual analog scale (VAS) results for ≥40 mm were randomized active or sham (high-frequency, primary motor cortex M1) plus 12 weeks (3...
Abstract Background Diaphragm dysfunction is highly prevalent in mechanically ventilated patients. Recent work showed that changes diaphragm shear modulus (ΔSMdi) assessed using ultrasound wave elastography (SWE) are strongly related to Pdi (ΔPdi) healthy subjects. The aims of this study were investigate the relationship between ΔSMdi and ΔPdi patients, whether responsive change respiratory load when varying ventilator settings. Methods A prospective, monocentric was conducted a 15-bed ICU....
Exercise intolerance in COPD seems to combine abnormal ventilatory mechanics, impaired O2 transport and skeletal muscle dysfunction. However their relatie contribution influence on symptoms reported by patients remain be clarified. In order clarify the complex interaction between neuromuscular exercise limiting factors symptoms, we evaluated respiratory muscles quadriceps contractile fatigue, dynamic hyperinflation induced exhaustive high-intensity cycling patients. Fifteen gold II-III (age...
Background. Neuromuscular diseases (NMD) are associated with gait impairments affecting quality of life. Contributing factors such as the severity muscle weakness or kinematics alterations have mostly been studied separately. Therefore, key determinants impaired in patients NMD remain unclear. This work aimed at investigating major through assessment weakness, lower limb kinematic, activation, and spatio-temporal parameters within a single session controls. Methods. Patients controls were...
The potential ergogenic effects of therapeutic inhaled salbutamol doses in endurance athletes have been controversially discussed for decades. We hypothesized that inhalation may increase peripheral muscle contractility, reduce fatigability, and improve force recovery after a localized exercise athletes.Eleven healthy, nonasthmatic male with high aerobic capacities were recruited to be compared double-blinded, randomized crossover study two dose levels (200 800 μg) placebo administered by...