A5048658964- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- Anesthesia and Pain Management
- Myofascial pain diagnosis and treatment
- Pain Management and Placebo Effect
- Pharmacological Effects and Toxicity Studies
- Migraine and Headache Studies
- Botulinum Toxin and Related Neurological Disorders
- Digital Mental Health Interventions
- Palliative Care and End-of-Life Issues
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Management and Treatment
- Olfactory and Sensory Function Studies
- Transcranial Magnetic Stimulation Studies
- Pediatric Pain Management Techniques
- Trigeminal Neuralgia and Treatments
- Hip and Femur Fractures
- Health, psychology, and well-being
- Complementary and Alternative Medicine Studies
- Sympathectomy and Hyperhidrosis Treatments
- Electromagnetic Fields and Biological Effects
- Health Systems, Economic Evaluations, Quality of Life
- Biofield Effects and Biophysics
Université Grenoble Alpes
2017-2025
Centre National de la Recherche Scientifique
2021-2025
Centre Hospitalier Universitaire de Grenoble
2017-2024
Hôpital Albert Michallon
2017-2023
Translational Innovation in Medicine and Complexity
2021-2023
Grenoble Institute of Neurosciences
2019
CEA Grenoble
2018
Hospices Civils de Lyon
2018
Hôpital Lariboisière
2017
Fibromyalgia is a common chronic pain pathology with an incidence of 4.3 per 1,000 person-years. An open, randomized clinical trial patients fibromyalgia comparing immediate vs. delayed 18-day spa therapy in five care facilities France enrolled 220 patients. Randomization was blocks four, stratified by center, severity and previous therapy. Patients continued usual treatment. The main endpoint the number achieving minimal clinically important difference at 6 months, defined as 14% change...
Fibromyalgia (FM) is a chronic painful condition partly due to alterations in pain modulation by the central nervous system. Multicomponent therapy (MT) and repetitive transcranial magnetic stimulation (rTMS) have both been reported as modulators patients with FM. The aim of this study was compare effects rTMS on combination MT versus alone.Thirty-nine FM visual analog scale (VAS) results for ≥40 mm were randomized active or sham (high-frequency, primary motor cortex M1) plus 12 weeks (3...
Background: This study assessed the efficacy of a therapy combining millimeter wave emitting wristband and coaching in improving quality life (QoL) Fibromyalgia (FM) patients, compared to standard care. Methods: An open, randomized clinical trial enrolled 170 patients with FM (2016 American College Rheumatology criteria, Impact Questionnaire score ≥ 39) from 8 French pain centers, Immediate versus Delayed therapy. Therapy was provided at inclusion (D0) month three (M3) groups respectively....
T-type calcium channels have been shown to play an important role in the initiation and maintenance of neuropathic pain represent a promising therapeutic target for new analgesic treatments. Ethosuximide (ETX), anticonvulsant channel blocker has effect several chronic models but not yet evaluated patients with pain.This proof-of-concept, multicentre, double-blind, controlled randomized trial compared efficacy safety ETX (given as add-on therapy) inactive control (IC) 114 non-diabetic...
Chronic pain affects approximately 30% of the general population, severely degrades quality life (especially in older adults) and professional (inability or reduction ability to work loss employment), leads billions additional health care costs. Moreover, available painkillers are old, with limited efficacy can cause significant adverse effects. Thus, there is a need for innovation management chronic pain. Better characterization patients could help identify predictors successful treatments,...
Background and objective Pain, a symptom often present in patients with Chronic Obstructive Pulmonary Disease (COPD), alters quality of life. COPD exacerbation augments several mechanisms that may cause pain (dyspnea, hyperinflation inflammation) therefore we hypothesized might be increased during exacerbation. Methods A prospective cohort study was conducted admitted for acute exacerbations (AECOPD) two emergency departments France Canada. Patients cancer-related or recent trauma were not...
There is no recommendation in Europe for the use of ketamine patients with chronic pain. The heterogeneity practice highlights need to seek advice experts order establish a national consensus. This Delphi survey aimed reach consensus on pain Pain clinics. A collaborative four-round internet-based questionnaire was used. It created after literature search administration and included about 96 items. discussed utility advantages, adverse events deleterious aspects, methods administration,...
Abstract Nitrous oxide (N 2 O) is an odorless and colorless gas routinely used as adjuvant of anesthesia for short-duration analgesia in various clinical settings mostly the form N O/O 50%-50% equimolar mixture (EMONO). Experimental studies have suggested that EMONO could also induce long-lasting analgesic effects related to blockade N-methyl-D-aspartate receptors. We designed first international multicenter proof concept randomized, placebo-controlled study assess efficacy safety a 1-hour...
Abstract Background Fibromyalgia is a form of chronic widespread pain that defined as syndrome symptoms moderate to severe intensity, including diffuse pain, fatigue, sleep disturbance, cognitive impairment, and numerous somatic complaints. To date, there no specific drug treatment for fibromyalgia but only symptomatic treatments. A free solution based on wristband emits millimeter waves associated with therapeutic coaching program was developed. The application an innervated area has been...
ABSTRACTABSTRACTIn humans, exposure to electromagnetic millimeter waves (MMW) has a hypoalgesic effect. In animals, this effect been shown depend on innervation density of the area exposed. This study aims assess and parasympathetic effects MMW applied palmar side wrist in healthy participants. within-subject design, 10 participants had their exposed (61.25 GHz, 17 mW/cm2) for 30 minutes, 1 h, & h30, minutes sham exposure. Experimental pain was induced after sessions with Cold Pressor Test,...
Les effets antalgiques des ondes millimétriques (OMM) ont été mis en évidence et utilisés cliniquement sur diverses affections années 1970 aux 1990. Ce n’est que plus récemment mécanismes impliquant une stimulation périphérique locale résultant réponse centrale sous forme de du système opioïde endogène a identifiée. Ces impliquent aussi d’autres neuromédiateurs (Dopamine) ainsi le nerveux autonome (activation parasympathique). Dans ces conditions, thérapeutiques dénuées toute toxicité...
<title>Abstract</title> Background Pain in older adults is historically neglected. The study assessed the ability of an audit and feedback (A&F) intervention built with nurses to improve quality perioperative pain management patients hospitalized for hip fracture. Methods Controlled before/after orthogeriatric unit (experimental group); a conventional orthopedic served as control (no intervention). Quality was evaluated based on acetaminophen distribution prescription adherence. primary...
<h3>Background</h3> Osteoarthritis (OA) is one of the most common chronic health conditions. Painful and very disabling, it affects about 500 million people worldwide. For its management, different guidelines recommend a combination non-pharmacological pharmacological treatments [1]. However, 90% patients in stop osteoarthritis I II survey feel that they are poorly managed terms their OA pain we currently lack effective means to do so [2]. We propose assess an innovative medical device (MD)...