A5107633743- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Respiratory Support and Mechanisms
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Syncope and Autonomic Disorders
- Sleep and related disorders
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
- Cardiovascular Disease and Adiposity
- Restless Legs Syndrome Research
- Dysphagia Assessment and Management
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Long-Term Effects of COVID-19
- Nutrition and Health in Aging
- Non-Invasive Vital Sign Monitoring
- Gastroesophageal reflux and treatments
Université Grenoble Alpes
2016-2025
Inserm
2016-2025
Centre Hospitalier Universitaire de Grenoble
2016-2025
Grenoble Institute of Neurosciences
2013-2024
Physiopathologie et Epidémiologie des Maladies Respiratoires
2012-2024
Saskatoon Medical Imaging
2022-2023
Dialyse Centrum Groningen
2022-2023
Geneva College
2023
Parks Victoria
2022-2023
Cooperative Trials Group for Neuro-Oncology
2022-2023
Obstructive sleep apnoea syndrome (OSAS) causes nocturnal chronic intermittent hypoxia (IH) that contributes to excess cardiovascular morbidity. To explore the consequences of IH, we used our recently developed model IH in healthy humans characterise profile this blood pressure increase, determine if it is sustained and potential physiological mechanisms. We performed 24-h ambulatory monitoring 12 subjects before after 2 weeks exposure. also assessed systemic haemodynamics, muscle...
Rationale: Excessive daytime sleepiness is a common disabling symptom in obstructive sleep apnea syndrome.Objectives: To evaluate the efficacy and safety of pitolisant, selective histamine H3 receptor antagonist with wake-promoting effects, for treatment patients moderate to severe refusing continuous positive airway pressure treatment.Methods: In an international, multicenter, double-blind, randomized (3:1), placebo-controlled, parallel-design trial, pitolisant was individually titrated at...
BackgroundRandomized controlled trials have failed to demonstrate an effect of CPAP therapy on mortality. However, these studies a number important limitations, including low adherence, patient selection, and small mortality events.Research QuestionWhat are the effects termination in first year all-cause patients with OSA from Nationwide Claims Data Lake for Sleep Apnea study?Study Design MethodsData Système National des Données de Santé (SNDS) database, French national health insurance...
Randomized controlled trials (RCTs) have shown that continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea (OSA) reduces blood (BP). CPAP has never been compared with antihypertensive medications in an RCT.To assess the respective efficacy and valsartan reducing BP hypertensive patients OSA treated for either condition.In this 8-week randomized crossover trial, 23 (office systolic BP/diastolic BP: 155 ± 14/102 11 mm Hg) (age, 57 8 yr; body mass index, 28 5 kg/m(2);...
Summary Hypoxic brain damage might explain persistent sleepiness in some continuous positive airway pressure‐compliant obstructive sleep apnea called residual excessive sleepiness. Although pressure may not be fully efficient treating this symptom, wake‐promoting drug prescription is no longer allowed by the E uropean M edicines A gency. The aim of study to describe phenotypes a large prospective sample patients with apnea. Residual was defined an pworth S leepiness cale score ≥ 11. Eligible...
Rationale In obstructive sleep apnea patients (OSA), continuous positive airway pressure (CPAP) adherence is crucial to improve symptoms and cardiometabolic outcomes. The choice of mask may influence CPAP but this issue has never been addressed properly. Objective To evaluate the impact nasal pillows, oronasal masks on in a cohort OSA. Methods Newly treated OSA participating “Observatoire Sommeil de la Fédération Pneumologie”, French national prospective cohort, were included between March...
The classification of obstructive sleep apnea is on the basis study criteria that may not adequately capture disease heterogeneity. Improved phenotyping improve prognosis prediction and help select therapeutic strategies.This used cluster analysis to investigate clinical clusters apnea.An ascending hierarchical was performed baseline symptoms, physical examination, risk factor exposure co-morbidities from 18,263 participants in OSFP (French national registry apnea). probability for be...
The American Academy of Sleep Medicine (AASM) guidelines for polysomnography (PSG) scoring are increasingly being adopted worldwide, but the agreement among international centers in respiratory events and sleep stages using these is unknown. We sought to determine interrater PSG centers.Prospective study scoring.Nine center-members Apnea Genetics International Consortium (SAGIC).Fifteen previously recorded deidentified PSGs, European Data Format, were scored by an experienced technologist at...
Chronic intermittent hypoxia (CIH) is thought to be responsible for the cardiovascular disease associated with obstructive sleep apnea (OSA). Increased sympathetic activation, altered vascular function, and inflammation are all putative mechanisms. We recently reported (Tamisier R, Gilmartin GS, Launois SH, Pepin JL, Nespoulet H, Thomas RJ, Levy P, Weiss JW. J Appl Physiol 107: 17-24, 2009) a new model of CIH in healthy humans that both increases blood pressure augmented peripheral...
AimsSleep fragmentation is a landmark of sleep disorders, because microarousals are systematically associated with sympathetic surges (i.e. arousals). However, the impact on blood pressure (BP) remains understudied. We assessed relationships between 24 h ambulatory BP monitoring, autonomic arousal index (AAI) derived from pulse transit time, and heart rate variability indices. hypothesized that repeated arousals during elevated in large population elderly volunteers.
The nationwide claims data lake for sleep apnoea (ALASKA)—real-life understanding and increasing obstructive apnea (OSA) quality of care study—investigated long-term continuous positive airway pressure (CPAP) termination rates, focusing on the contribution comorbidities. French national health insurance reimbursement system new CPAP users aged ≥18 years were analyzed. Innovative algorithms used to determine presence specific comorbidities (hypertension, diabetes chronic pulmonary disease...
Recent scientific findings in the field of sleep disordered breathing have characterised a variety phenotypes obstructive apnoea. These prompted investigations aiming to achieve more precise differentiation and description entities central apnoea (CSA). There is increasing evidence for heterogeneity CSA terms underlying aetiology, pathophysiological concepts, treatment response outcome. Assigning patients these allows selection individualised therapies. Major characteristics include loop...